Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Charlotte Wallaeys"'
Autor:
Steven Timmermans, Charlotte Wallaeys, Natalia Garcia-Gonzalez, Lotte Pollaris, Yvan Saeys, Claude Libert
Publikováno v:
Cells, Vol 13, Iss 17, p 1435 (2024)
The small intestinal crypts harbor secretory Paneth cells (PCs) which express bactericidal peptides that are crucial for maintaining intestinal homeostasis. Considering the diverse environmental conditions throughout the course of the small intestine
Externí odkaz:
https://doaj.org/article/5c669b8bb3464122a428313edbc52580
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-26 (2022)
Abstract Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by pro
Externí odkaz:
https://doaj.org/article/4841a5af76f84da8a2601b3f98ea63b4
Autor:
Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPolymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic pero
Externí odkaz:
https://doaj.org/article/d4cf3b606e8c4e34ae118f7e43e47016
Autor:
Jolien Souffriau, Steven Timmermans, Tineke Vanderhaeghen, Charlotte Wallaeys, Kelly Van Looveren, Lindsy Aelbrecht, Sylviane Dewaele, Jolien Vandewalle, Evy Goossens, Serge Verbanck, Filip Boyen, Melanie Eggermont, Lindsey De Commer, Riet De Rycke, Michiel De Bruyne, Raul Tito, Marlies Ballegeer, Sofie Vandevyver, Tiago Velho, Luis Ferreira Moita, Tino Hochepied, Karolien De Bosscher, Jeroen Raes, Filip Van Immerseel, Rudi Beyaert, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 10, Pp 1-21 (2020)
Abstract The cytokine TNF drives inflammatory diseases, e.g., Crohn's disease. In a mouse model of TNF‐induced systemic inflammatory response syndrome (SIRS), severe impact on intestinal epithelial cells (IECs) is observed. Zinc confers complete pr
Externí odkaz:
https://doaj.org/article/3e993b5bbeaf4e78b2bc46c529806814
Autor:
Lise Van Wyngene, Tineke Vanderhaeghen, Steven Timmermans, Jolien Vandewalle, Kelly Van Looveren, Jolien Souffriau, Charlotte Wallaeys, Melanie Eggermont, Sam Ernst, Evelien Van Hamme, Amanda Gonçalves, Guy Eelen, Anneleen Remmerie, Charlotte L Scott, Caroline Rombouts, Lynn Vanhaecke, Liesbet De Bus, Johan Decruyenaere, Peter Carmeliet, Claude Libert
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 2, Pp 1-20 (2020)
Abstract Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease; however, recent advances support the n
Externí odkaz:
https://doaj.org/article/7138be713e384661805942f933a9d08d
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-3 (2020)
Abstract Sepsis causes unacceptably high amounts of deaths worldwide. It is a huge unmet medical need, and new therapeutic interventions for sepsis and septic shock are urgently needed. By studying the mechanism by which a bacterial protein undermine
Externí odkaz:
https://doaj.org/article/9578b1217e684434b56653c478b9600c
Autor:
Lise Van Wyngene, Tineke Vanderhaeghen, Ioanna Petta, Steven Timmermans, Katrien Corbeels, Bart Van der Schueren, Jolien Vandewalle, Kelly Van Looveren, Charlotte Wallaeys, Melanie Eggermont, Sylviane Dewaele, Leen Catrysse, Geert van Loo, Rudi Beyaert, Roman Vangoitsenhoven, Toshinori Nakayama, Jan Tavernier, Karolien De Bosscher, Claude Libert
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102790- (2021)
Summary: The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body’s response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB domain containing 3
Externí odkaz:
https://doaj.org/article/3a3b104cdfd748ce878d5705d4550412
Autor:
Michael P. Pelst, Clara Höbart, Charlotte Wallaeys, Hilde De Rooster, Yannick Gansemans, Filip Van Nieuwerburgh, Bert Devriendt, Eric Cox
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Application of allergens onto the sublingual epithelium is used to desensitize allergic individuals, a treatment known as sublingual immunotherapy. However, the response of sublingual epithelial cells to house dust mite allergen and potential toleran
Externí odkaz:
https://doaj.org/article/7b5639cf923043b18f3aa86e19aac031
Publikováno v:
EMBO MOLECULAR MEDICINE
Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small intestine. In normal conditions, they function as the cornerstones of intestinal health by preserving homeostasis. They perform this function by providing ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c79e028d11a7b14ad7d962f3a28c7b3
https://hdl.handle.net/1854/LU-01GZE7F9E4VPMJ1QRSNDBTETA7
https://hdl.handle.net/1854/LU-01GZE7F9E4VPMJ1QRSNDBTETA7
Publikováno v:
Current Opinion in Pharmacology. 53:1-7
Glucocorticoids (GCs) are steroid hormones characterized by their anti-inflammatory and immunosuppressive nature. Although GCs are very commonly prescribed, in several diseases, including sepsis, their clinical treatment is hampered by side effects a