Transmissible Endosomal Intoxication: A Balance between Exosomes and Lysosomes at the Basis of Intercellular Amyloid Propagation

Autor: Anaïs Bécot, Charlotte Volgers, Guillaume van Niel

Publikováno v: Biomedicines, Vol 8, Iss 8, p 272 (2020)

In Alzheimer′s disease (AD), endolysosomal dysfunctions are amongst the earliest cellular features to appear. Each organelle of the endolysosomal system, from the multivesicular body (MVB) to the lysosome, contributes to the homeostasis of amyloid

Externí odkaz: https://doaj.org/article/c3c62bb903da4c9e9ec68a3cca218a37

Immunomodulatory role for membrane vesicles released by THP-1 macrophages and respiratory pathogens during macrophage infection

Autor: Gert Grauls, Frank R. M. Stassen, Charlotte Volgers, Paul H. M. Savelkoul, Birke J. Benedikter

Publikováno v: BMC Microbiology, Vol 17, Iss 1, Pp 1-14 (2017)
BMC Microbiology, 17:216. BioMed Central Ltd
BMC Microbiology
Volgers, C, Benedikter, B J, Grauls, G E, Savelkoul, P H M & Stassen, F R M 2017, ' Immunomodulatory role for membrane vesicles released by THP-1 macrophages and respiratory pathogens during macrophage infection ', BMC Microbiology, vol. 17, no. 1, 216 . https://doi.org/10.1186/s12866-017-1122-3
BMC Microbiology, 17(1):216. BioMed Central

Background: During infection, inflammation is partially driven by the release of mediators which facilitate intercellular communication. Amongst these mediators are small membrane vesicles (MVs) that can be released by both host cells and Gram-negati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cc5a35da78e3acbffb1af2fecd8734
https://doi.org/10.1186/s12866-017-1122-3

Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection

Autor: Frank R. M. Stassen, Paul H. M. Savelkoul, Pauline H. M. Hellebrand, Charlotte Volgers, Gert Grauls

Publikováno v: Inflammopharmacology
Inflammopharmacology, 25(6), 643-651. Springer
Inflammopharmacology, 25(6), 643-651. Birkhauser Verlag Basel
Volgers, C, Grauls, G E, Hellebrand, P H M, Savelkoul, P H M & Stassen, F R M 2017, ' Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection ', Inflammopharmacology, vol. 25, no. 6, pp. 643-651 . https://doi.org/10.1007/s10787-017-0359-7

Patients with more severe chronic obstructive pulmonary disease frequently experience exacerbations and it is estimated that up to 50% of these exacerbations are associated with bacterial infections. The mainstay treatment for these infection-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc13cf507ec7220bfac62ff7ebbea28
https://pubmed.ncbi.nlm.nih.gov/28528362

Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants

Autor: Niki L. Reynaert, Birke J. Benedikter, Gernot Rohde, Paul H. M. Savelkoul, Antje R. Weseler, Pascalle H. van Eijck, Charlotte Volgers, Emiel F.M. Wouters, Frank R. M. Stassen, Guido R.M.M. Haenen

Publikováno v: Free Radical Biology and Medicine, 108, 334-344. Elsevier Science

Introduction: Airway epithelial cells have been described to release extracellular vesicles (EVs) with pathological properties when exposed to cigarette smoke extract (CSE). As CSE causes oxidative stress, we investigated whether its oxidative compon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba12da174cf4d1e5d87163396d780c07
https://pubmed.ncbi.nlm.nih.gov/28359953

LSC Abstract – Extracellular vesicle release by macrophages during infection with non-typeable Haemophilus influenzae

Autor: Frank R. M. Stassen, Charlotte Volgers, Birke J. Benedikter, Paul H. M. Savelkoul

Publikováno v: 10.1 Respiratory Infections.

Introduction: Non-typeable Haemophilus influenzae (NTHi) colonizes the upper airways of most healthy adults and invades the lower airways when innate immunity is compromised. Control over infection is mainly conferred by alveolar macrophages and invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3ba9225869730bbb8511eb821e62260
https://doi.org/10.1183/13993003.congress-2015.pa2660