Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

Autor: Luhong Wang, Charlotte Vanacker, Laura L Burger, Tammy Barnes, Yatrik M Shah, Martin G Myers, Suzanne M Moenter

Publikováno v: eLife, Vol 8 (2019)

The brain regulates fertility through gonadotropin-releasing hormone (GnRH) neurons. Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release and positive feedback generating preovulatory GnRH/LH surges. Negative and pos

Externí odkaz: https://doaj.org/article/966fca31f2f54c01abf611ae3557adb3

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

Autor: Naresh Kumar Hanchate, Paolo Giacobini, Pierre Lhuillier, Jyoti Parkash, Cécile Espy, Corinne Fouveaut, Chrystel Leroy, Stéphanie Baron, Céline Campagne, Charlotte Vanacker, Francis Collier, Corinne Cruaud, Vincent Meyer, Alfons García-Piñero, Didier Dewailly, Christine Cortet-Rudelli, Ksenija Gersak, Chantal Metz, Gérard Chabrier, Michel Pugeat, Jacques Young, Jean-Pierre Hardelin, Vincent Prevot, Catherine Dodé

Publikováno v: PLoS Genetics, Vol 8, Iss 8, p e1002896 (2012)

Kallmann syndrome (KS) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. The genetics of KS involves various modes of transmission, including oligogenic inheritance. Here, we report that Nrp1(sema

Externí odkaz: https://doaj.org/article/c1e81f5391e44f4ab20b6d919cff8aa2

A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output in male mice

Autor: R. Anthony DeFazio, Suzanne M. Moenter, Charlene M Sykes, Charlotte Vanacker

Publikováno v: eLife, Vol 10 (2021)
eLife

GnRH neurons are the final central neural output regulating fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (KNDy neurons) are considered the main regulator of GnRH output. GnRH and KNDy neurons are surrounded by astrocytes, which c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4c658a7dc2be2fc073135d42f9ffb9
https://elifesciences.org/articles/68205

[Precocious puberty and neuropilin-1 signaling in GnRH neurons]

Autor: Charlotte, Vanacker, Sébastien G, Bouret, Paolo, Giacobini, Vincent, Prévot

Publikováno v: Medecine sciences : M/S. 37(4)

The survival of the species depends on two closely interlinked processes: the correct functioning of the reproductive system, and the balance between the energy needs of an individual and the supply of energy sources through feeding. These two proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6534d9ec2159ed2f4f9a0c023bd19376
https://pubmed.ncbi.nlm.nih.gov/33908854

Neuropilin-1 expression in GnRH neurons regulates prepubertal weight gain and sexual attraction

Autor: Naresh Kumar Hanchate, Samuel A. Malone, Andrea Messina, S. Rasika, Vincent Prevot, Filippo Casoni, Sonal Shruti, Sébastien G. Bouret, Gaetan Ternier, Philippe Ciofi, Sophie Croizier, Charlotte Vanacker, Sara Trova, Paolo Giacobini

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (19), ⟨10.15252/embj.2020104633⟩
EMBO Journal, 2020, 39 (19), pp.e104633. ⟨10.15252/embj.2020104633⟩
EMBO Journal, 2020, 39 (19), ⟨10.15252/embj.2020104633⟩
EMBO J
EMBO Journal, EMBO Press, 2020, 39 (19), pp.e104633. ⟨10.15252/embj.2020104633⟩

International audience; Hypothalamic neurons expressing gonadotropin-releasing hormone (GnRH), the "master molecule" regulating reproduction and fertility, migrate from their birthplace in the nose to their destination using a system of guidance cues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f4b9331c75bbdc3bfb48067482e6d5