A2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis

Autor: Marina Wendlandt, Alina J. Kürten, Antonia Beiersdorfer, Charlotte Schubert, Kiana Samad-Yazdtchi, Jessica Sauer, M. Carolina Pinto, Kristina Schulz, Manuel A. Friese, Christine E. Gee, Daniela Hirnet, Christian Lohr

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionThe cyclic nucleotide cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger, which is known to play an important anti-inflammatory role. Astrocytes in the central nervous system (CNS) can modulate inflammation but little

Externí odkaz: https://doaj.org/article/4efe47dd39af48f7be496c62d1ac970c

Wearable devices can predict the outcome of standardized 6-minute walk tests in heart disease

Autor: Charlotte Schubert, Gareth Archer, Jo M. Zelis, Sarah Nordmeyer, Kilian Runte, Anja Hennemuth, Felix Berger, Volkmar Falk, Pim A. L. Tonino, Rod Hose, Herman ter Horst, Titus Kuehne, Marcus Kelm

Publikováno v: npj Digital Medicine, Vol 3, Iss 1, Pp 1-9 (2020)

Abstract Wrist-worn devices with heart rate monitoring have become increasingly popular. Although current guidelines advise to consider clinical symptoms and exercise tolerance during decision-making in heart disease, it remains unknown to which exte

Externí odkaz: https://doaj.org/article/c3de71e5bdc4492693a6132c97809081

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

Autor: Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese

Publikováno v: eLife, Vol 10 (2021)

While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue neurodegene

Externí odkaz: https://doaj.org/article/d34d7f79b1524923b04c1e6c6a2626e7

Paraphrasensuche mittels word2vec und der Word Mover’s Distance im Altgriechischen

Autor: Marcus Pöckelmann, Jörg Ritter, Eva Wöckener-Gade, Charlotte Schubert

Publikováno v: Digital Classics Online, Vol 3, Iss 3, Pp 24-36 (2017)

To find receptions of Plato‘s work within the ancient Greek literature, automatic methods would be a useful assistance. Unfortunately, such methods are often knowledge-based and thus restricted to extensively annotated texts, which are not availabl

Externí odkaz: https://doaj.org/article/2693eacd8f37439ebd929f95fb04c237

Simulation-Based Training of the Rapid Evaluation and Management of Acute Stroke (STREAM)—A Prospective Single-Arm Multicenter Trial

Autor: Ferdinand O. Bohmann, Natalia Kurka, Richard du Mesnil de Rochemont, Katharina Gruber, Joachim Guenther, Peter Rostek, Heike Rai, Philipp Zickler, Michael Ertl, Ansgar Berlis, Sven Poli, Annerose Mengel, Peter Ringleb, Simon Nagel, Johannes Pfaff, Frank A. Wollenweber, Lars Kellert, Moriz Herzberg, Luzie Koehler, Karl Georg Haeusler, Anna Alegiani, Charlotte Schubert, Caspar Brekenfeld, Christopher E. J. Doppler, Oezguer A. Onur, Christoph Kabbasch, Tanja Manser, Waltraud Pfeilschifter, STREAM Trial Investigators, Mohammad Alotaibi, AbdulAziz Batarfi, Annemarie Brandhofe, Roxane-Isabelle Kestner, Jan Hendrik Schaefer, Martin Alexander Schaller, Alexander Seiler, Stephanie Wallenwein, Laurent M. Willems, Helmuth Steinmetz, Elke Hattingen, Zeljko Kos, Markus Naumann, Corinna Blum, Paula Bombach, Julia Zeller, Christoph Gumbinger, Jens Regula, Solveig Horstmann, Miriam Heyse, Eva Dorozewski, Christian Hamentner, Reiff Tilman, Simon Schieber, Sibu Mundiyanapurath, Silvia Schönenberger, Yahia Mokli, Markus Möhlenbruch, Jan Bewersdorf, Maximilian Einhäupl, Katharina Feil, Matthias Klein, Ken Möhwald, Konstanze Mühlbauer, Mathias Mulazzani, Guido Rohrer, Sonja Schönecker, Franziska Dorn, Philipp Mennemeyer, Torleif Sandner, Brigitte Huber, Julia Hill, Jela Gavran, Heinrich Audebert, Rohat Geran, Johannes Schurig, Juliane Herm, Felix Kleefeld, Karl Schoknecht, Denes Jadranka, Kirsten Brade, Tatjana Wittenberg, Ulrich Mayer-Runge, Maxim Bester, Michael H Schönfeld, Fabian Flottmann, Lisa Prilop, Hannes Leischner, Andreas Maximilian Frölich, Sabine Roesner, Gabriel Broocks, Uta Hanning, Stephanie Guder, Matthias Bechstein, Carmen Lange, Sebastian Kautz, Focko L. Higgen, Anna Kyselyova, Götz Thomalla, Jens Fiehler, Gereon Rudolf Fink, Anna Bonkhoff, Julian Dronse, Katharina Kirsch, Sarah Laurent, Boris von Reutern, Jurij Rosen, Lukas Volz, Jan-Michael Werner, Michael Wollring, Robert Seliger, Abdulkadir Yildirim, Marc Schlamann, Jan Borggrefe

Publikováno v: Frontiers in Neurology, Vol 10 (2019)

Introduction: Acute stroke care delivered by interdisciplinary teams is time-sensitive. Simulation-based team training is a promising tool to improve team performance in medical operations. It has the potential to improve process times, team communic

Externí odkaz: https://doaj.org/article/2db7fa3745d74107b86766cebb9b6d9e