Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Charlotte O'Donnell"'
1
IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist
Autor: Kevin Baker, Charlotte O’Donnell, Maura Bendix, Samuel Keogh, James Byrne, Michael O’Riordain, Peter Neary, Aileen Houston, Elizabeth Brint
Publikováno v: Oncogene. 41(19)
The IL-36 cytokines are a recently described subset of the IL-1 family of cytokines, shown to play a role in the pathogenesis of intestinal diseases such as Inflammatory Bowel Disease (IBD). Given the link between IBD and colitis –associated cancer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471541d9f8120aa673d12d1bc31d1ba7
https://pubmed.ncbi.nlm.nih.gov/35365751
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2
Abstract 1324: IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist
Autor: Kevin J. Baker, Charlotte O'Donnell, Micheal O'Riordain, Elizabeth Brint, Maura Bendix, Aileen Houston
Publikováno v: Cancer Research. 82:1324-1324
Background & Aims: The IL-1 subfamily, IL-36, is increasingly being implicated as a potent cytokine family involved in chronic inflammatory conditions such as psoriasis and IBD. Recent work has also suggested IL-36 cytokines may act as a potential ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3af7dab08d5983a30d5940f035938335
https://doi.org/10.1158/1538-7445.am2022-1324
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3
Wounds that heal and wounds that don't - The role of the IL-33/ST2 pathway in tissue repair and tumorigenesis
Autor: Charlotte O'Donnell, Iain B. McInnes, Elizabeth Brint, Neal L. Millar
Publikováno v: Seminars in celldevelopmental biology. 61
IL-33 is a member of the IL-1 family of cytokines. IL-33 is predominantly located within the nucleus of cells where it plays a role in gene regulation. Given the right combination of signals and cellular damage, stored IL-33 is released from the cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649c3d51a225c04581b9342f7f2c8ba2
https://pubmed.ncbi.nlm.nih.gov/27521518
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4
An antitumorigenic role for the IL-33 receptor, ST2L, in colon cancer
Autor: Charlotte O'Donnell, Aileen Houston, Sinead Carey, Jonathan Keane, Michael W. Bennett, Carola T. Murphy, Elizabeth Brint, Declan White, Micheal O'Riordain, Amr Mahmoud
Publikováno v: British Journal of Cancer
Background: Despite the importance of inflammation in cancer, the role of the cytokine IL-33, and its receptor ST2, in colon cancer is unclear. The aim of this study was to investigate the role of IL-33, and its receptor isoforms (ST2 and ST2L), in c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d6e057014bc98b5ae3723abc9af2e5
https://hdl.handle.net/10468/8457
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5
Do couples at high risk of relationship problems attend premarriage education?
Autor: Alfred Joseph Lizzio, Keithia Lynne Wilson, Charlotte O'Donnell, Kim Halford
Publikováno v: Journal of Family Psychology. 20:160-163
The effectiveness of premarriage education is limited by whether couples at high risk of future marital problems attend such education. In the current study, 374 newly married couples were assessed on a range of risk factors for future marital proble
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32ddb114e03209386188be31568b35d
https://doi.org/10.1037/0893-3200.20.1.160
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6
Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation
Autor: Charlotte O'Donnell, Philana Fernandes, Tim Regan, Aileen Houston, Stephen J. O'Brien, Elizabeth Brint, Padraic G. Fallon, Jonathan Keane, Caitriona Lyons
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 193(12)
TLRs play an important role in mediating intestinal inflammation and homeostasis. Fas is best studied in terms of its function in apoptosis, but recent studies demonstrate that Fas signaling may mediate additional functions such as inflammation. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a488dd980d11ef5b94e2e70f9e0a8d68
https://pubmed.ncbi.nlm.nih.gov/25378591
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