Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Charlotte Mary Griffiths-Jones"'
Autor:
Caroline Richardson, Zining Wu, Henriëtte M. G. Willems, William E. Wixted, Alison Jo-Anne Woolford, Charlotte Mary Griffiths-Jones, Yolanda Sanchez, David Norton, Jeffrey K. Kerns, T.G. Davies, William G. Bonnette, Sharna J. Rich, James F. Callahan, Hong Nie, Lawrence Wolfe, Maria Grazia Carr, Marcel L. Verdonk, William L. Rumsey, Tom D. Heightman
Publikováno v:
Journal of Medicinal Chemistry. 64:15949-15972
The NRF2-mediated cytoprotective response is central to cellular homoeostasis, and there is increasing interest in developing small-molecule activators of this pathway as therapeutics for diseases involving chronic oxidative stress. The protein KEAP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba196f8cf42319174247f8aba6d5c760
https://doi.org/10.1021/acs.jmedchem.1c01351
https://doi.org/10.1021/acs.jmedchem.1c01351
Autor:
Michael Reader, Aurélie Courtin, Steven Howard, Nicola G. Wallis, Jonathan Shannon, Hugh Walton, Christopher William Murray, Joseph E. Coyle, Joanne M. Munck, Alison Jo-Anne Woolford, Torren M. Peakman, David C. Rees, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Marc O'Reilly, Alpesh Shah, David Norton, Valerio Berdini, Lynsey Fazal, Maria Grazia Carr, Charlotte East, Tom D. Heightman, Nicola E. Wilsher, Ildiko Maria Buck, Luke Bevan, Stuart Thomas Onions, Michael Cooke, Justyna Kucia-Tran, Sandra Muench, Nick Palmer, Sharna J. Rich, Vanessa Martins, David Cousin, Puja Pathuri, John P. Watts
Publikováno v:
Journal of medicinal chemistry. 64(16)
Aberrant activation of the mitogen-activated protein kinase pathway frequently drives tumor growth, and the ERK1/2 kinases are positioned at a key node in this pathway, making them important targets for therapeutic intervention. Recently, a number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d0e8543148c5c72af0eca510047c9f
https://pubmed.ncbi.nlm.nih.gov/34387469
https://pubmed.ncbi.nlm.nih.gov/34387469
Autor:
Neil T. Thompson, Charlotte Mary Griffiths-Jones, John Lyons, Vanessa Martins, Nicola E. Wilsher, Tom D. Heightman, Harpreet K Saini, Juan Castro, Stuart Thomas Onions, David Cousin, Nicola G. Wallis, Valerio Berdini, Nick Palmer, Puja Pathuri, Caroline Richardson, Christopher William Murray, Charlotte East, John P. Watts, Marc O'Reilly, Sharna J. Rich, Hugh Walton, James Edward Harvey Day, Aurélie Courtin, Brent Graham, David C. Rees, Hannah Braithwaite, Michael Cooke, Ildiko Maria Buck, Michael Reader, Sandra Muench, Megan Cassidy, Jonathan Shannon, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Lynsey Fazal
Publikováno v:
Journal of Medicinal Chemistry. 61:4978-4992
Aberrant activation of the MAPK pathway drives cell proliferation in multiple cancers. Inhibitors of BRAF and MEK kinases are approved for the treatment of BRAF mutant melanoma, but resistance frequently emerges, often mediated by increased signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64bcd2385197c9e1b7f9532e4d26523
https://doi.org/10.1021/acs.jmedchem.8b00421
https://doi.org/10.1021/acs.jmedchem.8b00421
Autor:
Christopher N. Johnson, Nicola E. Wilsher, Vanessa Martins, Gianni Chessari, Aman Iqbal, Torren M. Peakman, Pamela A. Williams, Keisha Hearn, George Ward, Edward J. Lewis, James Edward Harvey Day, Ildiko Maria Buck, Charlotte Mary Griffiths-Jones, Tom D. Heightman, Michael Reader, Sharna J. Rich, Martyn Frederickson, Elisabetta Chiarparin, Emiliano Tamanini
Publikováno v:
Journal of Medicinal Chemistry. 60:4611-4625
XIAP and cIAP1 are members of the inhibitor of apoptosis protein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways. Overexpression of IAPs occurs in various cancers and has been associated with tumor progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d09110b6e7f734dc47b47bfcebcacb
https://doi.org/10.1021/acs.jmedchem.6b01877
https://doi.org/10.1021/acs.jmedchem.6b01877
Autor:
Nicola G. Wallis, Nick Palmer, Tom D. Heightman, Mike Reader, Sharna J. Rich, Hannah Braithwaite, Hugh Walton, James Edward Harvey Day, Valerio Berdini, Sandra Muench, Christopher W. Murray, Nicola E. Wilsher, Brent Graham, Neil Thompson, Harpreet K Saini, Charlotte Mary Griffiths-Jones, Caroline Richardson, Juan Castro, Vanessa Martins, Aurélie Courtin, Puja Pathuri, Marc O'Reilly, Charlotte East, David C. Rees, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Lynsey Fazal, Ildiko Maria Buck, John Lyons, Megan Cassidy
Publikováno v:
Molecular Cancer Therapeutics. 17:B161-B161
The RAS-RAF-MEK-ERK signalling cascade is activated through mutations in RAS or RAF in over 30% of cancers. The successful development of inhibitors of BRAF and MEK kinases has led to effective treatment particularly of melanomas whose tumor growth i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c708bbf81913113391a623dbb8c78ef
https://doi.org/10.1158/1535-7163.targ-17-b161
https://doi.org/10.1158/1535-7163.targ-17-b161
Autor:
Luke Bevan, John Lyons, Caroline Richardson, Charlotte Mary Griffiths-Jones, Juan Castro, Lukas Stanczuk, Alpesh Shah, Hugh Walton, Neil T. Thompson, Harpreet K Saini, Nicola G. Wallis, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Tom D. Heightman, Lynsey Fazal, Christopher J. Hindley, Christopher W. Murray, Hannah Braithwaite, Mike Reader, Vanessa Martins, Charlotte East, Puja Pathuri, Birikiti Kidane, Marc O'Reilly, David C. Rees, Aurélie Courtin, Megan Cassidy, Justyna Kucia-Tran, James Edward Harvey Day, Sandra Muench, Nicola E. Wilsher, Ildiko Maria Buck, Nick Palmer, Sharna J. Rich, Valerio Berdini, Brent Graham
Publikováno v:
Molecular Cancer Therapeutics. 17:B154-B154
The MAPK pathway is commonly hyper-activated in human cancers due to the occurrence of oncogenic mutations in RAF, RAS and the upregulation of RTKs. The therapeutic potential of MAPK pathway inhibition has been demonstrated by the clinical efficacy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb0f164a64005dde16a1115a0571fd2
https://doi.org/10.1158/1535-7163.targ-17-b154
https://doi.org/10.1158/1535-7163.targ-17-b154
Autor:
Keisha Hearn, Ildiko Maria Buck, Martyn Frederickson, Pamela A. Williams, Nicola E. Wilsher, Tomoko Smyth, Tom D. Heightman, Neil Thompson, Mike Reader, Charlotte Mary Griffiths-Jones, Aman Iqbal, Glyn Williams, Caroline Richardson, Anna Hopkins, Gianni Chessari, Vanessa Martins, Steven Howard, Joanne M. Munck, Alison Jo-Anne Woolford, James Edward Harvey Day, Ahn Maria, Petra Hillmann, Joe Coyle, Emiliano Tamanini, Christopher N. Johnson, George Ward, Lee William Page, Elisabetta Chiarparin, Gordon Saxty, Jon Lewis, Alessia Millemaggi
Publikováno v:
Cancer Research. 73:2944-2944
Melanoma is a highly aggressive malignancy with an exceptional ability to develop resistance and no curative therapy is available for patients with metastatic disease. Inhibitor of apoptosis proteins (IAP) play a key role in preventing cell death by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a89b1ed64b6f1fa716059b1d94293f30
https://doi.org/10.1158/1538-7445.am2013-2944
https://doi.org/10.1158/1538-7445.am2013-2944
Autor:
Frances Massey, Nicola E. Wilsher, Charlotte Mary Griffiths-Jones, Nicola G. Wallis, Christopher N. Johnson, Valerio Berdini, Neil Thompson, Tomoko Smyth, Caroline Richardson, Jayne Curry, Rachel McMenamin
Publikováno v:
Cancer Research. 72:2315-2315
Background: Methionine aminopeptidase (MetAP) 2 is one of the two eukaryotic enzymes responsible for cleaving the N-terminal methionine from newly synthesized polypeptides to allow further post-translational modifications such as myristoylation to ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0ae08f1376d6eb7a297de73529c0bf
https://doi.org/10.1158/1538-7445.am2012-2315
https://doi.org/10.1158/1538-7445.am2012-2315