Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Charlotte M. Proby"'
Autor:
Peter Bailey, Rachel A. Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D. Campbell, Emmanouil Dimonitsas, Alexander J. Stratigos, Sarah T. Arron, Jun Wang, Karen Blyth, Charlotte M. Proby, Catherine A. Harwood, Owen J. Sansom, Irene M. Leigh, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear. DNA sequencing studies h
Externí odkaz:
https://doaj.org/article/12b4077a59444dd3949da320a9c0d1e9
Autor:
Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene
Externí odkaz:
https://doaj.org/article/c362f4cc95db4024a0d3eb4b310fffac
Autor:
Regina Yu, BSc(Hon), Kyoko Miura, PhD, Daniel C. Chambers, FRACP, Peter M. Hopkins, FRACP, Charlotte M. Proby, FRCP, Kristin Bibee, MD, Elsemieke I. Plasmeijer, MD, Adele C. Green, MBBS, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 7, p e1492 (2023)
Background. We studied the feasibility of transplant-clinic staff routinely providing primary prevention advice to lung transplant recipients at high risk of skin cancer. Methods. Patients enrolled by a transplant-clinic study nurse completed baselin
Externí odkaz:
https://doaj.org/article/8ace6c029db447b69fbcc8a3204c62f8
Autor:
Kevin Roth, Louis Coussement, Elena V. Knatko, Maureen Higgins, Sandra Steyaert, Charlotte M. Proby, Tim de Meyer, Albena T. Dinkova-Kostova
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103383- (2021)
Background: Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Understanding the impact of DNA methylation in cSCC may provide avenues for new therapeutic strategies. Methods: We used reduced-re
Externí odkaz:
https://doaj.org/article/e8abffa692de4b15b023ab36e335f237
Autor:
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated w
Externí odkaz:
https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
Autor:
Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets
Externí odkaz:
https://doaj.org/article/879832a39de54eeeb00cc6a12113408e
Autor:
Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous
Externí odkaz:
https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a
Autor:
Karin J. Purdie, Charlotte M. Proby, Hasan Rizvi, Heather Griffin, John Doorbar, Mary Sommerlad, Mariet C. Feltkamp, Els Van der Meijden, Gareth J. Inman, Andrew P. South, Irene M. Leigh, Catherine A. Harwood
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Background: Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic me
Externí odkaz:
https://doaj.org/article/ae66638460604f449b4582a92dea391f
Autor:
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte M. Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley, Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene M. Leigh
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3428 (2019)
Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with increasing morbidity and mortality, with limited treatment options for advanced disease. Future improvements in targeted therapy will rely on advances in genomic/tr
Externí odkaz:
https://doaj.org/article/98119bebc7214a0dae59214416994d70
Autor:
Rachel Mary Fisher, Antonio Ji-Xu, Rachel Abbott, Tanya Basu, Alistair Brown, Catherine Foley, Catriona Glen, Girish Gupta, Zeeshaan Hasan, Ferina Ismail, Amina Khalid, Andre B. S. Khoo, Dimitra Koumaki, Aoife Lally, John T. Lear, Emily Jane McGrath, Kein McKenna, Alan Milligan, Orlagh Mulholland, Fiona Tasker, Catherine A. Harwood, Charlotte M. Proby, Rubeta N. Matin
Publikováno v:
Clinical and Experimental Dermatology. 47:1976-1981
Background Individuals with a prior diagnosis of chronic lymphocytic leukaemia (CLL) have a higher risk of developing melanoma and exhibit poorer outcomes than patients without CLL. However, there are limited data reporting the clinicopathological fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f22f024777b02111ba03834dedae2d0
https://doi.org/10.1111/ced.15324
https://doi.org/10.1111/ced.15324