Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Charlotte M. Proby"'
Autor:
Peter Bailey, Rachel A. Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D. Campbell, Emmanouil Dimonitsas, Alexander J. Stratigos, Sarah T. Arron, Jun Wang, Karen Blyth, Charlotte M. Proby, Catherine A. Harwood, Owen J. Sansom, Irene M. Leigh, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear. DNA sequencing studies h
Externí odkaz:
https://doaj.org/article/12b4077a59444dd3949da320a9c0d1e9
Autor:
Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Cells transmit mechanical force to the nucleus via the cytoskeleton. Here, the authors reveal a role for the actin regulator Mena in force transmission at the nuclear envelope, where it regulates nuclear architecture, chromatin organization and gene
Externí odkaz:
https://doaj.org/article/c362f4cc95db4024a0d3eb4b310fffac
Autor:
Regina Yu, BSc(Hon), Kyoko Miura, PhD, Daniel C. Chambers, FRACP, Peter M. Hopkins, FRACP, Charlotte M. Proby, FRCP, Kristin Bibee, MD, Elsemieke I. Plasmeijer, MD, Adele C. Green, MBBS, PhD
Publikováno v:
Transplantation Direct, Vol 9, Iss 7, p e1492 (2023)
Background. We studied the feasibility of transplant-clinic staff routinely providing primary prevention advice to lung transplant recipients at high risk of skin cancer. Methods. Patients enrolled by a transplant-clinic study nurse completed baselin
Externí odkaz:
https://doaj.org/article/8ace6c029db447b69fbcc8a3204c62f8
Autor:
Kevin Roth, Louis Coussement, Elena V. Knatko, Maureen Higgins, Sandra Steyaert, Charlotte M. Proby, Tim de Meyer, Albena T. Dinkova-Kostova
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103383- (2021)
Background: Cutaneous squamous cell carcinomas (cSCC) are among the most common and highly mutated human malignancies. Understanding the impact of DNA methylation in cSCC may provide avenues for new therapeutic strategies. Methods: We used reduced-re
Externí odkaz:
https://doaj.org/article/e8abffa692de4b15b023ab36e335f237
Autor:
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated w
Externí odkaz:
https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
Autor:
Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets
Externí odkaz:
https://doaj.org/article/879832a39de54eeeb00cc6a12113408e
Autor:
Rachel Mary Fisher, Antonio Ji-Xu, Rachel Abbott, Tanya Basu, Alistair Brown, Catherine Foley, Catriona Glen, Girish Gupta, Zeeshaan Hasan, Ferina Ismail, Amina Khalid, Andre B. S. Khoo, Dimitra Koumaki, Aoife Lally, John T. Lear, Emily Jane McGrath, Kein McKenna, Alan Milligan, Orlagh Mulholland, Fiona Tasker, Catherine A. Harwood, Charlotte M. Proby, Rubeta N. Matin
Publikováno v:
Clinical and Experimental Dermatology. 47:1976-1981
Background Individuals with a prior diagnosis of chronic lymphocytic leukaemia (CLL) have a higher risk of developing melanoma and exhibit poorer outcomes than patients without CLL. However, there are limited data reporting the clinicopathological fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f22f024777b02111ba03834dedae2d0
https://doi.org/10.1111/ced.15324
https://doi.org/10.1111/ced.15324
Autor:
Jay H Kalin, Abdulkerim Eroglu, Hua Liu, W David Holtzclaw, Irene Leigh, Charlotte M Proby, Jed W Fahey, Philip A Cole, Albena T Dinkova-Kostova
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213095 (2019)
Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deace
Externí odkaz:
https://doaj.org/article/f99b3105935445b2977644ef674fd19e
Autor:
Albena T. Dinkova-Kostova, Charlotte M. Proby, Tadashi Honda, Andrea L. Benedict, Sukirti Kalra, Akira Saito, Suqing Zheng, Rosemary Clarke, Jeffrey T.-J. Huang, James Ferguson, Robert S. Dawe, Paul Talalay, Jed W. Fahey, Maureen Higgins, Ying Zhang, Sally H. Ibbotson, Elena V. Knatko
The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding proteins with vers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69339df61a777f8d52704777198b5ebb
https://doi.org/10.1158/1940-6207.c.6544937
https://doi.org/10.1158/1940-6207.c.6544937
Autor:
Albena T. Dinkova-Kostova, Charlotte M. Proby, Tadashi Honda, Andrea L. Benedict, Sukirti Kalra, Akira Saito, Suqing Zheng, Rosemary Clarke, Jeffrey T.-J. Huang, James Ferguson, Robert S. Dawe, Paul Talalay, Jed W. Fahey, Maureen Higgins, Ying Zhang, Sally H. Ibbotson, Elena V. Knatko
Supplemental Figure S1. Spectral characteristics of UVA 340 lamps. Figure S2. Nrf2 disruption leads to an increase in the mRNA of Nrf3, but not Nrf1, in skin of SKH-1 hairless mice. Figure S3. TBE-31 treatment induces NQO1 in dermis and epidermis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471515a2418605a676187cbaa12c8627
https://doi.org/10.1158/1940-6207.22525847
https://doi.org/10.1158/1940-6207.22525847