Zobrazeno 1 - 10
of 470
pro vyhledávání: '"Charlotte M Niemeyer"'
Autor:
Vasil Toskov, Annamaria Cseh, Alexander Claviez, Natalia Rotari, Beatrice Drextler, Stephan Schwarz-Furlan, Matthias Braun, Peter Bader, Peter Lang, Rita Beier, Bernhard Erdlenbruch, Monika Führer, Miriam Erlacher, Charlotte M Niemeyer, Brigitte Strahm, Ayami Yoshimi
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100034- (2023)
Externí odkaz:
https://doaj.org/article/e1019d44747346d69351d3ada7dc922e
Autor:
Mattias Hofmans, Tim Lammens, Barbara Depreter, Ying Wu, Miriam Erlacher, Aurélie Caye, Hélène Cavé, Christian Flotho, Valerie de Haas, Charlotte M. Niemeyer, Jan Stary, Filip Van Nieuwerburgh, Dieter Deforce, Wouter Van Loocke, Pieter Van Vlierberghe, Jan Philippé, Barbara De Moerloose
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Juvenile myelomonocytic leukemia (JMML) treatment primarily relies on hematopoietic stem cell transplantation and results in long-term overall survival of 50–60%, demonstrating a need to develop novel treatments. Dysregulation of the non-c
Externí odkaz:
https://doaj.org/article/0585c9174d894b83a10e9c9210ba9f53
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
Friedrich G. Kapp, Cedric Schneider, Annegret Holm, Hannah Glonnegger, Charlotte M. Niemeyer, Jochen Rößler, Barbara Zieger
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1840 (2022)
Background: Vascular anomalies comprise a diverse group of rare diseases with altered blood flow and are often associated with coagulation disorders. The most common example is a localized intravascular coagulopathy in venous malformations leading to
Externí odkaz:
https://doaj.org/article/da67aa4bdad24e0ab7bb4b09fc3900fd
Autor:
Annegret Holm, Maroeska te Loo, Leo Schultze Kool, Päivi Salminen, Veronica Celis, Eulalia Baselga, Sophie Duignan, Veronika Dvorakova, Alan D. Irvine, Laurence M. Boon, Miikka Vikkula, Nader Ghaffarpour, Charlotte M. Niemeyer, Jochen Rössler, Friedrich G. Kapp
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Extensive lymphatic malformations (LMs) of the head and neck region may require tracheostomy to secure the airway. Treatment of these life-threatening LMs is usually multimodal and includes sclerotherapy and surgery, among others. Recently, systemic
Externí odkaz:
https://doaj.org/article/d2180b056612495081196bbb0e757f99
Autor:
Anna Dal Molin, Mattias Hofmans, Enrico Gaffo, Alessia Buratin, Hélène Cavé, Christian Flotho, Valerie de Haas, Charlotte M. Niemeyer, Jan Stary, Pieter Van Vlierberghe, Jan Philippé, Barbara De Moerloose, Geertruij te Kronnie, Silvia Bresolin, Tim Lammens, Stefania Bortoluzzi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Juvenile myelomonocytic leukemia (JMML), a rare myelodysplastic/myeloproliferative neoplasm of early childhood, is characterized by clonal growth of RAS signaling addicted stem cells. JMML subtypes are defined by specific RAS pathway mutations and di
Externí odkaz:
https://doaj.org/article/ef46116954d54794987bb5e59f8888b4
Autor:
Luca Vinci, Christian Flotho, Peter Noellke, Dirk Lebrecht, Riccardo Masetti, Valerie de Haas, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Tayfun Güngör, Jan Starý, Dominik Turkiewicz, Marek Ussowicz, Cristina Diaz de Heredia, Jochen Buechner, Kirsi Jahnukainen, Krisztian Kallay, Ivana Bodova, Owen P. Smith, Marco Zecca, Dorine Bresters, Peter Lang, Tania Nicole Masmas, Roland Meisel, Herbert Pichler, Miriam Erlacher, Gudrun Göhring, Franco Locatelli, Brigitte Strahm, Charlotte M. Niemeyer, Ayami Yoshimi
Publikováno v:
Scientia
Vinci, L, Flotho, C, Noellke, P, Lebrecht, D, Masetti, R, de Haas, V, De Moerloose, B, Dworzak, M, Hasle, H, Güngör, T, Starý, J, Turkiewicz, D, Ussowicz, M, de Heredia, C D, Buechner, J, Jahnukainen, K, Kallay, K, Bodova, I, Smith, O P, Zecca, M, Bresters, D, Lang, P, Masmas, T N, Meisel, R, Pichler, H, Erlacher, M, Göhring, G, Locatelli, F, Strahm, B, Niemeyer, C M & Yoshimi, A 2023, ' Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft ', Bone Marrow Transplantation, vol. 58, no. 5, pp. 607-609 . https://doi.org/10.1038/s41409-023-01942-4
Vinci, L, Flotho, C, Noellke, P, Lebrecht, D, Masetti, R, de Haas, V, De Moerloose, B, Dworzak, M, Hasle, H, Güngör, T, Starý, J, Turkiewicz, D, Ussowicz, M, de Heredia, C D, Buechner, J, Jahnukainen, K, Kallay, K, Bodova, I, Smith, O P, Zecca, M, Bresters, D, Lang, P, Masmas, T N, Meisel, R, Pichler, H, Erlacher, M, Göhring, G, Locatelli, F, Strahm, B, Niemeyer, C M & Yoshimi, A 2023, ' Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft ', Bone Marrow Transplantation, vol. 58, no. 5, pp. 607-609 . https://doi.org/10.1038/s41409-023-01942-4
Myeloproliferative disease; Paediatrics Enfermedad mieloproliferativa; Pediatría Malaltia mieloproliferativa; Pediatria Open Access funding enabled and organized by Projekt DEAL.
Autor:
Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho
Publikováno v:
Epigenetics, Vol 12, Iss 8, Pp 715-723 (2017)
Increased levels of fetal hemoglobin (HbF) are a hallmark of more than half of the children diagnosed with juvenile myelomonocytic leukemia (JMML). Elevated HbF levels in JMML are associated with DNA hypermethylation of distinct gene promoter regions
Externí odkaz:
https://doaj.org/article/46b22d2d9f224fcfaa035f5003c1a5c6
Autor:
Akiko Shimamura, Alexey Maschan, Carolyn Bennett, Jason E Farrar, Sujith Samarasinghe, Brigitte Strahm, Winfred C. Wang, Adrianna Vlachos, Charlotte M. Niemeyer, Timothy S. Olson, Denise D'Alessio, Elise Burmeister Getz, Tomasz Lawniczek, Yunnan Xu, David A. Williams
Publikováno v:
Blood. 140:705-707
Autor:
Themis-Areti A. Andreoti, Sebastian Berg, Annegret Holm, Marina Angerer, Michael Oberlin, Etelka Foeldi, Iris Baumgartner, Charlotte M. Niemeyer, Jochen Rössler, Friedrich G. Kapp
Publikováno v:
Lymphatic Research and Biology.
Objective: Generalized lymphatic anomaly (GLA), Gorham-Stout disease (GSD), kaposiform lymphangiomatosis (KLA), and central conducting lymphatic anomaly (CCLA) are rare, multisystem lymphatic disorders, referred to as complex lymphatic anomalies (CLA