Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria

Autor: Charlotte M. J. Wesseling, Thomas M. Wood, Cornelis J. Slingerland, Kristine Bertheussen, Samantha Lok, Nathaniel I. Martin

Publikováno v: Molecules, Vol 26, Iss 7, p 1954 (2021)

The continued rise of antibiotic resistance threatens to undermine the utility of the world’s current antibiotic arsenal. This problem is particularly troubling when it comes to Gram-negative pathogens for which there are inherently fewer antibioti

Externí odkaz: https://doaj.org/article/7bf4e355b14d4e9bbe2275b3e62b07ba

Synthesis and Structure-Activity Studies of beta-Barrel Assembly Machine Complex Inhibitor MRL-494

Autor: Nicola Wade, Charlotte M. J. Wesseling, Paolo Innocenti, Cornelis J. Slingerland, Gregory M. Koningstein, Joen Luirink, Nathaniel I. Martin

Publikováno v: ACS Infectious Diseases. AMER CHEMICAL SOC
ACS Infectious Diseases
ACS Infectious Diseases, 8(11). ACS
Wade, N, Wesseling, C M J, Innocenti, P, Slingerland, C J, Koningstein, G M, Luirink, J & Martin, N I 2022, ' Synthesis and Structure-Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494 ', ACS Infectious Diseases, vol. 8, no. 11, pp. 2242–2252 . https://doi.org/10.1021/acsinfecdis.2c00459
ACS Infectious Diseases, 8(11), 2242-2252. American Chemical Society (ACS)

In the hunt for new antibiotics with activity against Gram-negative pathogens, the outer membrane β-barrel assembly machine (BAM) complex has become an increasingly interesting target. The recently reported BAM complex inhibitor, MRL-494, was discov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a29089e349fd600301eed4e6d08c2e
http://hdl.handle.net/1887/3566788

Synthetic studies with the brevicidine and laterocidine lipopeptide antibiotics including analogues with enhanced properties and

Autor: Karol, Al Ayed, Ross D, Ballantine, Michael, Hoekstra, Samantha J, Bann, Charlotte M J, Wesseling, Alexander T, Bakker, Zheng, Zhong, Yong-Xin, Li, Nora C, Brüchle, Mario, van der Stelt, Stephen A, Cochrane, Nathaniel I, Martin

Publikováno v: Chemical science. 13(12)

Brevicidine and laterocidine are two recently discovered lipopeptide antibiotics with promising antibacterial activity. Possessing a macrocyclic core, multiple positive charges, and a lipidated N-terminus, these lipopeptides exhibit potent and select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e304ff04a2c60c19c28036840a6d5528
https://pubmed.ncbi.nlm.nih.gov/35432860