Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Charlotte M Flynn"'
Autor:
Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Publikováno v:
PLoS Biology, Vol 15, Iss 1, p e2000080 (2017)
Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely
Externí odkaz:
https://doaj.org/article/0de46d7cf5e847c6bf5e71b31996514a
Autor:
Charlotte M. Flynn, Yvonne Garbers, Stefan Düsterhöft, Rielana Wichert, Juliane Lokau, Christian H. K. Lehmann, Diana Dudziak, Bernd Schröder, Christoph Becker-Pauly, Stefan Rose-John, Samadhi Aparicio-Siegmund, Christoph Garbers
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract The cytokine interleukin-6 (IL-6) fulfills its pleiotropic functions via different modes of signaling. Regenerative and anti-inflammatory activities are mediated via classic signaling, in which IL-6 binds to the membrane-bound IL-6 receptor
Externí odkaz:
https://doaj.org/article/5fcbad4a86ec408db5a8eceac4164627
Autor:
Maria Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel, Birte Kespohl, Philipp Arnold, Charlotte M. Flynn, Juliane Lokau, Samadhi Aparicio-Siegmund, Christian Bretscher, Stefan Rose-John, Georg H. Waetzig, Tracy Putoczki, Joachim Grötzinger, Christoph Garbers
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 10-18.e5 (2018)
Summary: Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene enc
Externí odkaz:
https://doaj.org/article/a5e04e6be0b747889149d6367b2b4483
Autor:
Heiner K. Berthold, Christoph Garbers, Samadhi Aparicio-Siegmund, Matthias Laudes, Ioanna Gouni-Berthold, Yvonne Garbers, Charlotte M. Flynn, Georg H. Waetzig, Wilhelm Krone, Stefan Rose-John
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 317:E411-E420
Serum levels of interleukin-6 (IL-6) are increased in patients with type 2 diabetes (T2D). IL-6 exerts its pleiotropic effects via the IL-6 α-receptor (IL-6R), which exists in membrane-bound and soluble (sIL-6R) forms and activates cells via the β-
Autor:
Daniela Wesch, Yvonne Garbers, Matthias Laudes, Charlotte M. Flynn, Juliane Lokau, Dominik M. Schulte, Samadhi Aparicio-Siegmund, Christoph Garbers, Wolfgang Lieb
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) via its soluble IL-6R (sIL-6R) has been termed trans-signaling and is thought to be responsible for the pro-inflammatory properties of IL-6. The sIL-6R can be generated by alternative mRNA sp
Autor:
Joachim Grötzinger, Tracy L Putoczki, Samadhi Aparicio-Siegmund, Julian Brügge, Philipp Arnold, Stefan Rose-John, Yvonne Garbers, Christian Bretscher, Marieke Wandel, Charlotte M. Flynn, Juliane Lokau, Birte Kespohl, Maria Agthe, Georg H. Waetzig, Christoph Garbers
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 10-18.e5 (2018)
Summary: Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene enc
Autor:
Juliane Lokau, Johannes Haybaeck, Tina Daunke, Yvonne Garbers, Stefan Rose-John, Birte Kespohl, Samadhi Aparicio-Siegmund, Christoph Garbers, Charlotte M. Flynn, Stefan Düsterhöft
Publikováno v:
The Journal of Biological Chemistry
Interleukin-6 (IL-6) is a cytokine implicated in proinflammatory as well as regenerative processes and acts via receptor complexes consisting of the ubiquitously expressed, signal-transducing receptor gp130 and the IL-6 receptor (IL-6R). The IL-6R is
Publikováno v:
Biochemical and biophysical research communications. 491(2)
The cytokine Interleukin-11 (IL-11) signals through the membrane-bound IL-11 receptor (IL-11R), which is expressed in a cell-type specific manner. We have recently shown that the metalloprotease ADAM10 can cleave the IL-11R. The liberated soluble IL-
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1864(11 Pt)
Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important homeostatic functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-11R and IL-6R, respectively). Formation of IL-11/IL-11R and IL
Autor:
Stefan Düsterhöft, Markus Hessefort, Inken Lorenzen, Dominik Stahnke, Yijue Zhu, Kosuke Yamamoto, Andreas Tholey, Joachim Grötzinger, Alexander Albrecht, Charlotte M. Flynn, Tomas Koudelka, Maria Agthe, Prasath Somasundaram, Carlo Unverzagt, Steffen Riethmueller, Ute Pickhinke, Johanna C. Ehlers, Marisa Rädisch, Christoph Garbers, Juliane Lokau, Stefan Rose-John, Rielana Wichert, Christoph Becker-Pauly, Chien-Wen Hung
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 1, p e2000080 (2017)
PLoS Biology, Vol 15, Iss 1, p e2000080 (2017)
Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely