Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Charlotte M Deane"'
Autor:
Eve Richardson, Špela Binter, Miha Kosmac, Marie Ghraichy, Valentin von Niederhäusern, Aleksandr Kovaltsuk, Jacob D Galson, Johannes Trück, Dominic F Kelly, Charlotte M Deane, Paul Kellam, Simon J Watson
Publikováno v:
eLife, Vol 12 (2023)
Immunoglobulin loci-transgenic animals are widely used in antibody discovery and increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell populations from the Intelliselect Transgenic mouse (Kymouse) demonstra
Externí odkaz:
https://doaj.org/article/8edf1acdf29a48b99e78fa6ee6f633dc
Autor:
Sarah A Robinson, Matthew I J Raybould, Constantin Schneider, Wing Ki Wong, Claire Marks, Charlotte M Deane
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 12, p e1009675 (2021)
Identifying the epitope of an antibody is a key step in understanding its function and its potential as a therapeutic. Sequence-based clonal clustering can identify antibodies with similar epitope complementarity, however, antibodies from markedly di
Externí odkaz:
https://doaj.org/article/4e45c3c1a33549b1a054b5116753e881
Autor:
Marie Ghraichy, Valentin von Niederhäusern, Aleksandr Kovaltsuk, Jacob D Galson, Charlotte M Deane, Johannes Trück
Publikováno v:
eLife, Vol 10 (2021)
Several human B cell subpopulations are recognised in the peripheral blood, which play distinct roles in the humoral immune response. These cells undergo developmental and maturational changes involving VDJ recombination, somatic hypermutation and cl
Externí odkaz:
https://doaj.org/article/19f3a9204ee7438d934efd000e121258
Autor:
Matthew I J Raybould, Claire Marks, Aleksandr Kovaltsuk, Alan P Lewis, Jiye Shi, Charlotte M Deane
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008781 (2021)
The naïve antibody/B-cell receptor (BCR) repertoires of different individuals ought to exhibit significant functional commonality, given that most pathogens trigger an effective antibody response to immunodominant epitopes. Sequence-based repertoire
Externí odkaz:
https://doaj.org/article/25733d2a183f483f900eb2877fe4c75c
Autor:
Alex Macpherson, Maisem Laabei, Zainab Ahdash, Melissa A Graewert, James R Birtley, Monika-Sarah ED Schulze, Susan Crennell, Sarah A Robinson, Ben Holmes, Vladas Oleinikovas, Per H Nilsson, James Snowden, Victoria Ellis, Tom Eirik Mollnes, Charlotte M Deane, Dmitri Svergun, Alastair DG Lawson, Jean MH van den Elsen
Publikováno v:
eLife, Vol 10 (2021)
Bovines have evolved a subset of antibodies with ultra-long heavy chain complementarity determining regions that harbour cysteine-rich knob domains. To produce high-affinity peptides, we previously isolated autonomous 3–6 kDa knob domains from bovi
Externí odkaz:
https://doaj.org/article/11009d4406c0451a844e90851ac87e3f
Autor:
Aleksandr Kovaltsuk, Matthew I J Raybould, Wing Ki Wong, Claire Marks, Sebastian Kelm, James Snowden, Johannes Trück, Charlotte M Deane
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007636 (2020)
Most current analysis tools for antibody next-generation sequencing data work with primary sequence descriptors, leaving accompanying structural information unharnessed. We have used novel rapid methods to structurally characterize the complementary-
Externí odkaz:
https://doaj.org/article/a1a3d6bfc23646c3895acfba9e2ad92f
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007338 (2019)
T cells use their T-cell receptors (TCRs) to scan other cells for antigenic peptides presented by MHC molecules (pMHC). If a TCR encounters a pMHC, it can trigger a signalling pathway that could lead to the activation of the T cell and the initiation
Externí odkaz:
https://doaj.org/article/e08830510ceb48b4bce61936ecde1c4d
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0218149 (2019)
While template-free protein structure prediction protocols now produce good quality models for many targets, modelling failure remains common. For these methods to be useful it is important that users can both choose the best model from the hundreds
Externí odkaz:
https://doaj.org/article/18d5bff4a3a54d31a92138ce67aab9d6
Autor:
Carlos Outeiral, Garrett M Morris, Jiye Shi, Martin Strahm, Simon C Benjamin, Charlotte M Deane
Publikováno v:
New Journal of Physics, Vol 23, Iss 10, p 103030 (2021)
Protein folding is a central challenge in computational biology, with important applications in molecular biology, drug discovery and catalyst design. As a hard combinatorial optimisation problem, it has been studied as a potential target problem for
Externí odkaz:
https://doaj.org/article/ff0b0e914a274b299dffeeb04d6b0359
Autor:
Samuel Demharter, Nicholas Pearce, Kylie Beattie, Isabel Frost, Jinwoo Leem, Alistair Martin, Robert Oppenheimer, Cristian Regep, Tammo Rukat, Alexander Skates, Nicola Trendel, David J Gavaghan, Charlotte M Deane, Bernhard Knapp
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 5, p e1005512 (2017)
Externí odkaz:
https://doaj.org/article/87aff83779474d909af97ab2ff6a0cca