Výsledky vyhledávání - "Charlotte Lespade"

Activation of MAPK/ERK signalling in Merlin-null Schwann cells leads to increased and sustained immune cell infiltration in the peripheral nervous system

Autor: Evyn Woodhouse, Liyam Laraba, David Parkinson, Alison C. Lloyd, Charlotte Lespade, Marie Srotyr

Publikováno v: Neuro Oncol

Aims Previous work has shown that increased numbers of macrophages are associated with more rapid schwannoma tumour growth and we are interested in signals that control entry of macrophages and other immune cells into these tumours. Activation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc43611f335d25ad42b3f2ea2f55f38
https://europepmc.org/articles/PMC8517855/

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Use of a new mouse schwannoma tumour model to monitor changes in peripheral nerve morphology in Merlin null Schwann cells

Autor: Charlotte Lespade, Evyn Woodhouse, David Parkinson, Glenn M. Harper, Alison C. Lloyd, Marie Srotyr, Liyam Laraba

Publikováno v: Neuro Oncol

Aims Our lab is interested in signals that trigger schwannoma tumour formation and we have previously shown that peripheral nerve injury triggers tumour formation in nerves with Schwann cell-specific loss of the Merlin (NF2) tumour suppressor. The Ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5371ab1367e243e4bd1ff1e4c236a1d8
https://doi.org/10.1093/neuonc/noab195.014

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Activation of Raf signalling in NF2-null Schwann cells leads to sustained proliferation; an investigation of a new and inducible model for human schwannoma

Autor: Liyam Laraba, Marie Srotyr, Evyn Woodhouse, David Parkinson, Charlotte Lespade, Alison C. Lloyd

Publikováno v: Neuro Oncol

Aims The NF2 gene encodes the tumour suppressor Merlin, which is deleted in 100% of patients with the familial tumour predisposition syndrome neurofibromatosis type 2 but also in 70% of those who develop sporadic schwannomas. The Raf-TR mouse model u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd325700ae6c6891613830df51f7edd4
https://doi.org/10.1093/neuonc/noab195.013

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