Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Charlotte Leese"'
Autor:
Aisha Zhantleuova, Charlotte Leese, Anna P. Andreou, Altynay Karimova, Guy Carpenter, Bazbek Davletov
Publikováno v:
Toxins, Vol 16, Iss 4, p 175 (2024)
This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox or el-iBoNT
Externí odkaz:
https://doaj.org/article/ab65cefcbc054cbc870d11c962d83ec5
Autor:
Charlotte Leese, Rebecca Bresnahan, Ciara Doran, Deniz Simsek, Alexander D. Fellows, Laura Restani, Matteo Caleo, Giampietro Schiavo, Timur Mavlyutov, Tina Henke, Thomas Binz, Bazbek Davletov
Publikováno v:
Toxicon: X, Vol 5, Iss , Pp - (2020)
Neurological diseases constitute a quarter of global disease burden and are expected to rise worldwide with the ageing of human populations. There is an increasing need to develop new molecular systems which can deliver drugs specifically into neuron
Externí odkaz:
https://doaj.org/article/c98449bca144423a86be5fb3d6a37649
Autor:
Frederic D. Darios, Jernej Jorgacevski, Ajda Flašker, Robert Zorec, Virginia García-Martinez, José Villanueva, Luis M. Gutiérrez, Charlotte Leese, Manjot Bal, Elena Nosyreva, Ege T. Kavalali, Bazbek Davletov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Neurotransmission and secretion of hormones involve a sequence of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane. We previously demonstrate
Externí odkaz:
https://doaj.org/article/9eaa40d0e3454fffa98e5440007fc225
There is an urgent need for new pain-relieving therapies. We have previously shown using mouse models of persistent pain that a single intrathecal injection of substance P conjugated to the light chain of botulinum toxin (SP-BOT) silenced neurons in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ddb62df3a90731e99788e3886b542a5
https://doi.org/10.1101/2020.12.28.423185
https://doi.org/10.1101/2020.12.28.423185
Autor:
Laura Restani, Rebecca Bresnahan, Alexander D. Fellows, Charlotte Leese, Thomas Binz, Giampietro Schiavo, Tina Henke, Bazbek Davletov, Matteo Caleo, Timur A. Mavlyutov, Deniz Simsek, Ciara Doran
Publikováno v:
Toxicon
Toxicon: X, Vol 5, Iss, Pp-(2020)
Toxicon: X, Vol 5, Iss, Pp-(2020)
Neurological diseases constitute a quarter of global disease burden and are expected to rise worldwide with the ageing of human populations. There is an increasing need to develop new molecular systems which can deliver drugs specifically into neuron
Publikováno v:
Toxicon. 190:S45-S46
Autor:
Cristina Tassorelli, Rashid Giniatullin, Oleg Gafurov, Anna Zanaboni, Rosaria Greco, Ksenia Koroleva, Eve Corrie, Deniz Simsek, Charlotte Leese, Giorgio Lambru, Anna P. Andreou, Ciara Doran, Elizabeth P. Seward, Bazbek Davletov, Chiara Demartini, Joseph O Lloyd
Publikováno v:
Toxicon. 190:S5
With a prevalence of 15%, migraine is the most common neurological disorder and among the most disabling diseases, taking into account years lived with disability. Current oral medications for migraine show variable effects and are frequently associa
Autor:
Hung Tae Kim, Miles L. Epstein, Bazbek Davletov, Jay Yang, Charlotte Leese, Tyler Duellman, Timur A. Mavlyutov
Publikováno v:
Neuroscience. 331:148-157
Sigma-1 receptor (S1R) is a unique pluripotent modulator of living systems and has been reported to be associated with a number of neurological diseases including pathological pain. Intrathecal administration of S1R antagonists attenuates the pain be
Autor:
Stephen P. Hunt, Michelangelo Certo, Maria Maiarù, Bazbek Davletov, Charlotte Leese, Antonina Stefania Mangione, Jason Arsenault, Irene Echeverria-Altuna
Publikováno v:
Science translational medicine. 10(450)
Chronic pain is a widespread debilitating condition affecting millions of people worldwide. Although several pharmacological treatments for relieving chronic pain have been developed, they require frequent chronic administration and are often associa
Autor:
Ciara Doran, Matthew R Balmforth, Michael E. Webb, Maria Maiarù, Rebecca Bresnahan, Bazbek Davletov, Charlotte Leese, Stephen P. Hunt, Bruce Turnbull
Publikováno v:
Toxicon. 156:S20