Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Charlotte L. Bevan"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Androgen deprivation therapy (ADT) is the core treatment for advanced prostate cancer (PCa), with a proven survival benefit. ADT lowers circulating testosterone levels throughout the body, but with it comes a variety of reported side effects
Externí odkaz:
https://doaj.org/article/5b6b9ce0dae144a8841359d7040de19d
Autor:
Foteini Kalofonou, Damien A. Leach, Sue M. Powell, Jonathan Waxman, Claire E. Fletcher, Charlotte L. Bevan
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
In most patients with advanced prostate cancer treated with hormonal therapy, androgen independence eventually emerges, leading to death. Androgen receptor signalling remains an important prostate cancer driver, even in the advanced disease stage. Mi
Externí odkaz:
https://doaj.org/article/6ab9e41067c5471a993b08fb1e757ab1
Publikováno v:
Biosensors, Vol 14, Iss 9, p 443 (2024)
Current diagnostic and prognostic tests for prostate cancer require specialised laboratories and have low specificity for prostate cancer detection. As such, recent advancements in electrochemical devices for point of care (PoC) prostate cancer detec
Externí odkaz:
https://doaj.org/article/6d4eeda0723f4425ad61dc64fbed81a8
Autor:
Lucy Penfold, Angela Woods, Alice E. Pollard, Julia Arizanova, Eneko Pascual-Navarro, Phillip J. Muckett, Marian H. Dore, Alex Montoya, Chad Whilding, Louise Fets, Joao Mokochinski, Theodora A. Constantin, Anabel Varela-Carver, Damien A. Leach, Charlotte L. Bevan, Alexander Yu. Nikitin, Zoe Hall, David Carling
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112396- (2023)
Summary: Emerging evidence indicates that metabolic dysregulation drives prostate cancer (PCa) progression and metastasis. AMP-activated protein kinase (AMPK) is a master regulator of metabolism, although its role in PCa remains unclear. Here, we sho
Externí odkaz:
https://doaj.org/article/11a6b824917b48fc8d5c5b5a9e0faa99
Autor:
Shenglin Cai, Thomas Pataillot-Meakin, Akifumi Shibakawa, Ren Ren, Charlotte L. Bevan, Sylvain Ladame, Aleksandar P. Ivanov, Joshua B. Edel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
miRNA profiling from patient blood can be used for cancer diagnosis. Here the authors present an electro-optical nanopore sensing platform which allows sensitive and specific miRNA detection directly in human serum and apply to monitoring of miR-141-
Externí odkaz:
https://doaj.org/article/d3c563e3e37e455093e426357d5c1670
Autor:
Charlotte L. Bevan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-3 (2021)
A bank of 59 well-characterised prostate cancer patient-derived xenografts was established, including 17 classed as research-ready covering the disease-spectrum which, plus associated resources (organoids, serum, DNA/RNA profiles, tissue), are availa
Externí odkaz:
https://doaj.org/article/feb3485b07fb4d0dbd2023b9e45716e3
Autor:
Manjunath Siddappa, Sajad A. Wani, Mark D. Long, Damien A. Leach, Ewy A. Mathé, Charlotte L. Bevan, Moray J. Campbell
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract In prostate cancer (PCa), and many other hormone-dependent cancers, there is clear evidence for distorted transcriptional control as disease driver mechanisms. Defining which transcription factor (TF) and coregulators are altered and combine
Externí odkaz:
https://doaj.org/article/4631e065a23b463eb4e0b14a0f46990a
Autor:
Ieva Eringyte, Joanna N. Zamarbide Losada, Sue M. Powell, Charlotte L. Bevan, Claire E. Fletcher
Publikováno v:
Asian Journal of Urology, Vol 7, Iss 3, Pp 233-250 (2020)
The androgen receptor (AR) remains a key driver of prostate cancer (PCa) progression, even in the advanced castrate-resistant stage, where testicular androgens are absent. It is therefore of critical importance to understand the molecular mechanisms
Externí odkaz:
https://doaj.org/article/d920d4a3430144f1b38b73135e018996
Autor:
James W. Hindley, Yuval Elani, Catriona M. McGilvery, Simak Ali, Charlotte L. Bevan, Robert V. Law, Oscar Ces
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Matryoshka doll-like, nested vesicles, each containing a different ingredient to a chemical reaction, can serve as microreactors. Here, the authors developed a system in which mixing of the ingredients can be induced by irradiation with ultraviolet l
Externí odkaz:
https://doaj.org/article/70757d22ec7b4fbd9828bd4dc7607b93
Publikováno v:
F1000Research, Vol 5 (2016)
Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owi
Externí odkaz:
https://doaj.org/article/6d9e01f9ea594b72ab65729989aa7e39