Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Charlotte Lässig"'
Autor:
Charlotte Lässig, Katja Lammens, Jacob Lucián Gorenflos López, Sebastian Michalski, Olga Fettscher, Karl-Peter Hopfner
Publikováno v:
eLife, Vol 7 (2018)
The innate immune sensor retinoic acid-inducible gene I (RIG-I) detects cytosolic viral RNA and requires a conformational change caused by both ATP and RNA binding to induce an active signaling state and to trigger an immune response. Previously, we
Externí odkaz:
https://doaj.org/article/95aad86e8de74fad8fceea1251db4c5a
Autor:
Charlotte Lässig, Sarah Matheisl, Konstantin MJ Sparrer, Carina C de Oliveira Mann, Manuela Moldt, Jenish R Patel, Marion Goldeck, Gunther Hartmann, Adolfo García-Sastre, Veit Hornung, Karl‐Klaus Conzelmann, Roland Beckmann, Karl-Peter Hopfner
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/d2557d7a40c040cabde3ba3a39064587
Autor:
Charlotte Lässig, Sarah Matheisl, Konstantin MJ Sparrer, Carina C de Oliveira Mann, Manuela Moldt, Jenish R Patel, Marion Goldeck, Gunther Hartmann, Adolfo García-Sastre, Veit Hornung, Karl-Klaus Conzelmann, Roland Beckmann, Karl-Peter Hopfner
Publikováno v:
eLife, Vol 4 (2015)
The cytosolic antiviral innate immune sensor RIG-I distinguishes 5′ tri- or diphosphate containing viral double-stranded (ds) RNA from self-RNA by an incompletely understood mechanism that involves ATP hydrolysis by RIG-I's RNA translocase domain.
Externí odkaz:
https://doaj.org/article/2e811ce05e7446f6a397f6eb374e63a6
Autor:
Simon Runge, Konstantin M J Sparrer, Charlotte Lässig, Katharina Hembach, Alina Baum, Adolfo García-Sastre, Johannes Söding, Karl-Klaus Conzelmann, Karl-Peter Hopfner
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004081 (2014)
RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA. Upon RNA binding, RLRs trigger a complex do
Externí odkaz:
https://doaj.org/article/543293be775c45319f7265a2d0c778e1
Autor:
David Belada, Katerina Kopeckova, Juan Miguel Bergua Burgues, Don Stevens, Grzegorz S. Nowakowski, Maeve Waldron-Lynch, Nira Hadar, Johannes Weirather, Charlotte Lässig, Derek Blair, Martin Dreyling
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:S352
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fbff6f8967febe93f78c2f2d2dd7d90
https://doi.org/10.1016/s2152-2650(22)01487-2
https://doi.org/10.1016/s2152-2650(22)01487-2
Autor:
Teng Huang, Jessica J. Chiang, Karl-Peter Hopfner, Konstantin M. J. Sparrer, Michaela U. Gack, Nikolaus Osterrieder, Charlotte Lässig, Michiel van Gent
Publikováno v:
Nature Immunology. 19:53-62
The sensor RIG-I detects double-stranded RNA derived from RNA viruses. Although RIG-I is also known to have a role in the antiviral response to DNA viruses, physiological RNA species recognized by RIG-I during infection with a DNA virus are largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6c7de16cc8b5d4116e1e247bf2f25d
https://doi.org/10.1038/s41590-017-0005-y
https://doi.org/10.1038/s41590-017-0005-y
Autor:
Charlotte Lässig, Karl-Peter Hopfner
Publikováno v:
Journal of Biological Chemistry. 292:9000-9009
RIG-I-like receptors (RLRs) are cytosolic innate immune sensors that detect pathogenic RNA and induce a systemic antiviral response. During the last decade, many studies focused on their molecular characterization and the identification of RNA agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fded7ff5a62aadc14566d2c7c339ad1
https://doi.org/10.1074/jbc.r117.788398
https://doi.org/10.1074/jbc.r117.788398
Autor:
Katja Lammens, Karl-Peter Hopfner, Jacob Lucián Gorenflos López, Sebastian Michalski, Charlotte Lässig, Olga Fettscher
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
The innate immune sensor retinoic acid-inducible gene I (RIG-I) detects cytosolic viral RNA and requires a conformational change caused by both ATP and RNA binding to induce an active signaling state and to trigger an immune response. Previously, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed28858c9ed1fbb8862878c35b27299
https://doi.org/10.7554/elife.38958
https://doi.org/10.7554/elife.38958
Autor:
Karl-Peter Hopfner, Charlotte Lässig
Publikováno v:
Trends in Microbiology. 24:517-519
RIG-I-like receptors detect cytosolic viral RNA and activate an antiviral innate immune response. A new study employs the one STrEP-purification technique and next generation sequencing to characterize physiological ligands in an infected cell. The v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5409bc021c6a918720f05ddfab80d8d1
https://doi.org/10.1016/j.tim.2016.05.001
https://doi.org/10.1016/j.tim.2016.05.001