Profound Functional Suppression of Tumor-Infiltrating T-Cells in Ovarian Cancer Patients Can Be Reversed Using PD-1-Blocking Antibodies or DARPin® Proteins

Autor: Emelie Foord, Charlotte Klynning, Esther Schoutrop, Judith M. Förster, Jennifer Krieg, Anette Mörtberg, Mischa R. Müller, Christel Herzog, Dieter Schiegg, Denis Villemagne, Ulrike Fiedler, Dan Snell, Benjamin Kebble, Jonas Mattsson, Victor Levitsky, Michael Uhlin

Publikováno v: Journal of Immunology Research, Vol 2020 (2020)

PD-1/PD-L1 blockade has revolutionized the field of immunooncology. Despite the relative success, the response rate to anti-PD-1 therapy requires further improvements. Our aim was to explore the enhancement of T-cell function by using novel PD-1-bloc

Externí odkaz: https://doaj.org/article/1b8abe36663a4d659c3c6bc13e5ba077

Methylseleninic Acid Sensitizes Ovarian Cancer Cells to T-Cell Mediated Killing by Decreasing PDL1 and VEGF Levels

Autor: Deepika Nair, Emelie Rådestad, Prajakta Khalkar, Nuria Diaz-Argelich, Axel Schröder, Charlotte Klynning, Johanna Ungerstedt, Michael Uhlin, Aristi P. Fernandes

Publikováno v: Frontiers in Oncology, Vol 8 (2018)

Redox active selenium (Se) compounds at sub toxic doses act as pro-oxidants with cytotoxic effects on tumor cells and are promising future chemotherapeutic agents. However, little is known about how Se compounds affect immune cells in the tumor micro

Externí odkaz: https://doaj.org/article/9e14d820710d43dda1c3b7f1d70ef30a

Immune profiling and identification of prognostic immune-related risk factors in human ovarian cancer

Autor: Michael Uhlin, Ole Mogensen, Emelie Rådestad, Arwen Stikvoort, Charlotte Klynning, Silvia Nava, Isabelle Magalhaes

Publikováno v: OncoImmunology, 8(2). Landes Bioscience
OncoImmunology, Vol 8, Iss 2 (2019)
Rådestad, E, Klynning, C, Stikvoort, A, Mogensen, O, Nava, S, Magalhaes, I & Uhlin, M 2019, ' Immune profiling and identification of prognostic immune-related risk factors in human ovarian cancer ', OncoImmunology, vol. 8, no. 2 . https://doi.org/10.1080/2162402X.2018.1535730
Oncoimmunology

Suppression of immune reactivity by increased expression of co-inhibitory receptors has been discussed as a major reason as to why the immune system fails to control tumor development. Elucidating the co-inhibitory expression pattern of tumor-infiltr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba52d621442b3d12c523f91f33fbc9c
https://pubmed.ncbi.nlm.nih.gov/30713791