Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

Autor: Weiwei Shi, Charlotte K.Y. Ng, Raymond S. Lim, Tingting Jiang, Sushant Kumar, Xiaotong Li, Vikram B. Wali, Salvatore Piscuoglio, Mark B. Gerstein, Anees B. Chagpar, Britta Weigelt, Lajos Pusztai, Jorge S. Reis-Filho, Christos Hatzis

Publikováno v: Cell Reports, Vol 25, Iss 6, Pp 1446-1457 (2018)

Summary: Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically disti

Externí odkaz: https://doaj.org/article/351fc94f181746789c58f10deb88347b

Data from DNA Methylation Landscapes of Prostate Cancer Brain Metastasis Are Shaped by Early Driver Genetic Alterations

Autor: Salvatore Piscuoglio, Mark A. Rubin, Charlotte K.Y. Ng, Silke Gillessen, Felix Y. Feng, George Thalmann, Holger Moch, Lukas Bubendorf, Adeboye O. Osunkoya, Gieri Cathomas, Wolfram Jochum, Ingeborg Fischer, Rainer Grobholz, Elisabeth J. Rushing, Achim Fleischmann, Vera Genitsch, Ekkehard Hewer, Ursula Amstutz, Sina Maletti, Dilara Akhoundova, Andrej Benjak, Antonio Rodriguez-Calero, John Gallon

Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c01e91a2e85cb1dd840d1e92384f00
https://doi.org/10.1158/0008-5472.c.6599642.v1

DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations

Autor: John Gallon, Antonio Rodriguez-Calero, Andrej Benjak, Dilara Akhoundova, Sina Maletti, Ursula Amstutz, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Felix Y. Feng, Silke Gillessen, Charlotte K.Y. Ng, Mark A. Rubin, Salvatore Piscuoglio

Publikováno v: Gallon, John; Rodríguez-Calero, Antonio; Benjak, Andrej; Akhoundova, Dilara; Maletti, Sina; Amstutz, Ursula; Hewer, Ekkehard; Genitsch, Vera; Fleischmann, Achim; Rushing, Elisabeth J; Grobholz, Rainer; Fischer, Ingeborg; Jochum, Wolfram; Cathomas, Gieri; Osunkoya, Adeboye O; Bubendorf, Lukas; Moch, Holger; Thalmann, George; Feng, Felix Y; Gillessen, Silke; ... (2023). DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations. Cancer research, 83(8), pp. 1203-1213. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-22-2236
Cancer research, vol. 83, no. 8, pp. 1203-1213

Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce9031aefed757cc227ffba65be48c1
https://boris.unibe.ch/178505/1/can-22-2236.pdf

Supplementary Tables from Infiltration by IL22-Producing T Cells Promotes Neutrophil Recruitment and Predicts Favorable Clinical Outcome in Human Colorectal Cancer

Autor: Raoul Andre Droeser, Giandomenica Iezzi, Serenella Eppenberger-Castori, Giulio Spagnoli, Markus von Flüe, Salvatore Piscuoglio, Charlotte K.Y. Ng, Luigi Terracciano, Luigi Tornillo, Dimitri Christoforidis, Pietro Edoardo Majno, Giuseppe Sconocchia, Silvio Däster, Benjamin Weixler, Francesca Amicarella, Mairene Coto-Llerena, Venkatesh Kancherla, Camilla Basso, Valeria Governa, Eleonora Cremonesi, Nadia Tosti

Supplementary Tables 1-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bdd577f63df88aa8a5e0ba845dc9d1
https://doi.org/10.1158/2326-6066.22542928.v1

Supplementary Table I from Therapeutic Targeting of CD146/MCAM Reduces Bone Metastasis in Prostate Cancer

Autor: George N. Thalmann, Marianna Kruithof-de Julio, Marco G. Cecchini, Peter Kloen, Gabri van der Pluijm, Kenneth Flanagan, Ewa B. Snaar-Jagalska, Lanpeng Chen, Irena Klima, Joël Grosjean, Janine Melsen, Salvatore Piscuoglio, Charlotte K.Y. Ng, Letizia Astrologo, Eugenio Zoni

Primers used for qPCR.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c3664a7a44bb81d7b5ffad9e4d2d14
https://doi.org/10.1158/1541-7786.22516036.v1