Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Charlotte K. Colenso"'
1
Akademický článek
Sequence and structural conservation reveal fingerprint residues in TRP channels
Autor: Deny Cabezas-Bratesco, Francisco A Mcgee, Charlotte K Colenso, Kattina Zavala, Daniele Granata, Vincenzo Carnevale, Juan C Opazo, Sebastian E Brauchi
Publikováno v: eLife, Vol 11 (2022)
Transient receptor potential (TRP) proteins are a large family of cation-selective channels, surpassed in variety only by voltage-gated potassium channels. Detailed molecular mechanisms governing how membrane voltage, ligand binding, or temperature c
Externí odkaz: https://doaj.org/article/b300337cbf56419f86ffbabb4e515e03
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2
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase
Autor: Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
Publikováno v: Tooke, C L, Hinchliffe, P, Beer, M, Zinovjev, K, Colenso, C K, Schofield, C J, Mulholland, A J & Spencer, J 2023, ' Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase ', Journal of the American Chemical Society, vol. 145, no. 13, pp. 7166-7180 . https://doi.org/10.1021/jacs.2c12123
KPC-2 (Klebsiella pneumoniae carbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c97774ccd121ac85e5e4f7e2ef074a
https://hdl.handle.net/1983/c1ddb86c-11e5-4b02-9062-d77f3e36a9db
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3
Multiscale Workflow for Modeling Ligand Complexes of Zinc Metalloproteins
Autor: Silvia Gervasoni, Eric J. M. Lang, Adrian J. Mulholland, Reynier Suardíaz, James Spencer, Charlotte K. Colenso, Zongfan Yang, Rebecca M. Twidale
Publikováno v: Yang, Z, Twidale, R M, Gervasoni, S, Suardíaz, R, Colenso, C K, Lang, E J M, Spencer, J & Mulholland, A J 2021, ' Multiscale Workflow for Modeling Ligand Complexes of Zinc Metalloproteins ', Journal of Chemical Information and Modeling, vol. 61, no. 11, pp. 5658-5672 . https://doi.org/10.1021/acs.jcim.1c01109
Zinc metalloproteins are ubiquitous, with protein zinc centers of structural and functional importance, involved in interactions with ligands and substrates and often of pharmacological interest. Biomolecular simulations are increasingly prominent in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59458a45589ff68f2d3ba1ccc3254d0a
https://doi.org/10.1021/acs.jcim.1c01109
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4
Tautomer-specific deacylation and Ω-loop flexibility explain carbapenem-hydrolyzing, broad-spectrum activity of the KPC-2 β-lactamase
Autor: Catherine L. Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K. Colenso, Christopher J. Schofield, Adrian J. Mulholland, James Spencer
KPC-2 (Klebsiella pneumoniaecarbapenemase-2) is a globally disseminated serine-β-lactamase (SBL) responsible for extensive β-lactam antibiotic resistance in Gram-negative pathogens. SBLs inactivate β-lactams via a mechanism involving a hydrolytica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5ef8b8613c4bc3d2d7e2c5e2ca429b5
https://doi.org/10.1101/2022.11.11.516172
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5
Sequence and structural conservation reveal fingerprint residues in TRP channels
Autor: Francisco A Mcgee, Deny Cabezas-Bratesco, Charlotte K Colenso, Kattina Zavala, Daniele Granata, Vincenzo Carnevale, Juan C Opazo, Sebastian E Brauchi
Publikováno v: eLife. 11
Transient receptor potential (TRP) proteins are a large family of cation-selective channels, surpassed in variety only by voltage-gated potassium channels. Detailed molecular mechanisms governing how membrane voltage, ligand binding, or temperature c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a14ed8fe73a6881f823f9d617c64bc
https://doi.org/10.7554/elife.73645
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7
Evolutionary analyses reveal independent origins of gene repertoires and structural motifs associated to fast inactivation in calcium-selective TRPV channels
Autor: Juan C. Opazo, Lisandra Flores-Aldama, Wendy González, Michael W. Vandewege, Kattina Zavala, Charlotte K. Colenso, Sebastian Brauchi
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Essential for calcium homeostasis, TRPV5 and TRPV6 are calcium-selective channels belonging to the transient receptor potential (TRP) gene family. In this study, we investigated the evolutionary history of these channels to add an evolutionary contex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431e78e09fccd5ef2d2f9fff14b36ff6
http://link.springer.com/article/10.1038/s41598-020-65679-6
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8
Sequence conservation and structural features that are common within TRP channels
Autor: Juan C. Opazo, Deny Cabezas-Bratesco, Danielle Granata, Sebastian Brauchi, Katina Zavala, Vincenzo Carnevale, Charlotte K. Colenso
TRP proteins are a large family of cation selective channels, surpassed in variety only by voltage-gated potassium channels. Detailed molecular mechanisms governing how membrane voltage, ligand binding, or temperature can induce conformational change
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd79a028e46fdbee61c14676b4124a0f
https://doi.org/10.1101/2021.09.06.459056
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9
Akademický článek
Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils.
Autor: Carolina Manosalva, Jaqueline Mena, Zahady Velasquez, Charlotte K Colenso, Sebastian Brauchi, Rafael A Burgos, Maria A Hidalgo
Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119715 (2015)
Long chain fatty acids (LCFAs), which are ligands for the G-protein coupled receptor FFAR1 (GPR40), are increased in cow plasma after parturition, a period in which they are highly susceptible to infectious diseases. This study identified and analyze
Externí odkaz: https://doaj.org/article/e72f447c2a1140e7bf9af665521195d2
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10
β-Lactamases and β-Lactamase Inhibitors in the 21st Century
Autor: James Spencer, Catherine L. Tooke, Philip Hinchliffe, Yuiko Takebayashi, Viivi H. A. Hirvonen, Charlotte K. Colenso, Eilis C. Bragginton
Publikováno v: Journal of Molecular Biology
Tooke, C, Hinchliffe, P, Bragginton, E, Colenso, C K, Hirvonen, V, Takebayashi, Y & Spencer, J 2019, ' β-Lactamases and β-Lactamase Inhibitors in the 21st Century ', Journal of Molecular Biology . https://doi.org/10.1016/j.jmb.2019.04.002
The β-lactams retain a central place in the antibacterial armamentarium. In Gram-negative bacteria, β-lactamase enzymes that hydrolyze the amide bond of the four-membered β-lactam ring are the primary resistance mechanism, with multiple enzymes di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc19dc6247df2029d1d290c042b56f03
http://europepmc.org/articles/PMC6723624
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