Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Charlotte K. Billington"'
1
Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis
Autor: Amanda L. Tatler, Christopher J. Philp, Michael R. Hill, Sam Cox, Andrew M. Bullock, Anthony Habgood, Alison John, Robert Middlewick, Katherine E. Stephenson, Amanda T. Goodwin, Charlotte K. Billington, Reuben D. O’Dea, Simon R. Johnson, Bindi S. Brook
Publikováno v: L284
L271
Airway remodeling occurs in chronic asthma leading to increased airway smooth muscle (ASM) mass and extracellular matrix (ECM) deposition. Although extensively studied in murine airways, studies report only selected larger airways at one time-point m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f29c15e63a47bc73bf1e9eeeda7b2d
https://doi.org/10.1152/ajplung.00034.2022
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2
Akademický článek
Defining the inflammatory signature of human lung explant tissue in the presence and absence of glucocorticoid [version 1; referees: 2 approved]
Autor: Tracy L Rimington, Emily Hodge, Charlotte K Billington, Sangita Bhaker, Binaya K C, Iain Kilty, Scott Jelinsky, Ian P Hall, Ian Sayers
Publikováno v: F1000Research, Vol 6 (2017)
Background: Airway inflammation is a feature of many respiratory diseases and there is a need for newer, more effective anti-inflammatory compounds. The aim of this study was to develop an ex vivo human lung explant model which can be used to help st
Externí odkaz: https://doaj.org/article/2beaa65a72814bba8b062eba6979408a
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3
Akademický článek
The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.
Autor: Suzanne Miller, Amanda P Henry, Emily Hodge, Alexander K Kheirallah, Charlotte K Billington, Tracy L Rimington, Sangita K Bhaker, Ma'en Obeidat, Erik Melén, Simon K Merid, Caroline Swan, Catherine Gowland, Carl P Nelson, Ceri E Stewart, Charlotte E Bolton, Iain Kilty, Anders Malarstig, Stuart G Parker, Miriam F Moffatt, Andrew J Wardlaw, Ian P Hall, Ian Sayers
Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164041 (2016)
Genome-Wide Association Studies have identified associations between lung function measures and Chronic Obstructive Pulmonary Disease (COPD) and chromosome region 6p21 containing the gene for the Advanced Glycation End Product Receptor (AGER, encodin
Externí odkaz: https://doaj.org/article/fddddc60e55d4be390faa9c32649f704
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4
Proinflammatory Effects in Ex Vivo Human Lung Tissue of Respirable Smoke Extracts from Indoor Cooking in Nepal
Autor: Siva Praveen Puppala, Amanda P. Henry, Binaya Kc, Dhruma Thakker, Ian P. Hall, Charlotte K. Billington, Ian Sayers, Parth Sarathi Mahapatra
Publikováno v: Annals of the American Thoracic Society. 17:688-698
Rationale: Exposure to biomass smoke is believed to increase the risk of developing chronic obstructive pulmonary disease. However, little is known about the mechanisms underlying responses to biom...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27c40cd891ea3736e2e87cf9053328e4
https://doi.org/10.1513/annalsats.201911-827oc
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5
Akademický článek
The role of inflammation resolution speed in airway smooth muscle mass accumulation in asthma: insight from a theoretical model.
Autor: Igor L Chernyavsky, Huguette Croisier, Lloyd A C Chapman, Laura S Kimpton, Jonathan E Hiorns, Bindi S Brook, Oliver E Jensen, Charlotte K Billington, Ian P Hall, Simon R Johnson
Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90162 (2014)
Despite a large amount of in vitro data, the dynamics of airway smooth muscle (ASM) mass increase in the airways of patients with asthma is not well understood. Here, we present a novel mathematical model that describes qualitatively the growth dynam
Externí odkaz: https://doaj.org/article/7dbb3a86909349c9b4fd145bf4f2df73
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6
Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells
Autor: Dhruma Thakker, Robert J. Hall, Ian P. Hall, Charlotte K. Billington, Jonathan O’Loughlin, Ian Sayers
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(7)
GPR126 is an adhesion G protein-coupled receptor which lies on chromosome 6q24. Genetic variants in this region are reproducibly associated with lung function and COPD in genome wide association studies (GWAS). The aims of this study were to define t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45944cf0f0b3d6ea4df013b8baf5c01b
https://pubmed.ncbi.nlm.nih.gov/34165809
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7
Akademický článek
GSTCD and INTS12 regulation and expression in the human lung.
Autor: Ma'en Obeidat, Suzanne Miller, Kelly Probert, Charlotte K Billington, Amanda P Henry, Emily Hodge, Carl P Nelson, Ceri E Stewart, Caroline Swan, Louise V Wain, María Soler Artigas, Erik Melén, Kevin Ushey, Ke Hao, Maxime Lamontagne, Yohan Bossé, Dirkje S Postma, Martin D Tobin, Ian Sayers, Ian P Hall
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74630 (2013)
Genome-Wide Association Study (GWAS) meta-analyses have identified a strong association signal for lung function, which maps to a region on 4q24 containing two oppositely transcribed genes: glutathione S-transferase, C-terminal domain containing (GST
Externí odkaz: https://doaj.org/article/29ed6b1386194cdc9e6d41e5c57cb629
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10
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium
Autor: Charlotte K. Billington, Gerard H. Koppelman, Liam G Heaney, Adel H. Mansur, Jenny Hankinson, Martijn C. Nawijn, Corry-Anke Brandsma, Sangita Bhaker, Andrew M. Fogarty, Dominick E. Shaw, Michael A. Portelli, Cornelis J. Vermeulen, Judith M. Vonk, Nick Shrine, Amanda P. Henry, Ian Sayers, Yohan Bossé, Maria Ketelaar, Martin D. Tobin, Peter H. Howarth, David C. Nickle, Néomi S. Grotenboer, Ma'en Obeidat, Gabrielle A. Lockett, John W. Holloway, Christopher E. Brightling, Alen Faiz, Rekha Chaudhuri, Tricia M. McKeever, Simon R. Johnson, Paul de Vos, Dirkje S. Postma, Zara Pogson, Neil C. Thomson, Sharon Brouwer, Maarten van den Berge, Angela Simpson, Amisha Singapuri, Robert Niven, F. Nicole Dijk, Ian P. Hall, Louise V. Wain, John D Blakey
Publikováno v: Portelli, M A, Dijk, F N, Ketelaar, M E, Shrine, N, Hankinson, J, Bhaker, S, Grotenboer, N S, Obeidat, M, Henry, A P, Billington, C K, Shaw, D, Johnson, S R, Pogson, Z E, Fogarty, A, McKeever, T M, Nickle, D C, Bossé, Y, van den Berge, M, Faiz, A, Brouwer, S, Vonk, J M, de Vos, P, Brandsma, C-A, Vermeulen, C J, Singapuri, A, Heaney, L G, Mansur, A H, Chaudhuri, R, Thomson, N C, Holloway, J W, Lockett, G A, Howarth, P H, Niven, R, Simpson, A, Blakey, J D, Tobin, M D, Postma, D S, Hall, I P, Wain, L V, Nawijn, M C, Brightling, C E, Koppelman, G H & Sayers, I 2020, ' Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium ', JCI insight, vol. 5, no. 8, pp. 1-19 . https://doi.org/10.1172/jci.insight.132446
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35eec0d3bd47361ef723e102569f7099
https://doi.org/10.1172/jci.insight.132446
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