Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Charlotte J. Hardy"'
Autor:
Máire A. Convery, Daniel Thomas, Chris D. Edwards, Craig Jamieson, James E. Rowedder, Ian Robert Baldwin, David N. Mallett, Chun-wa Chung, Charlotte J. Hardy, Nick Barton, Jonathan A. Spencer, Paul Rowland
Publikováno v:
ACS Med Chem Lett
[Image: see text] A macrocyclization approach has been explored on a series of benzoxazine phosphoinositide 3-kinase δ inhibitors, resulting in compounds with improved potency, permeability, and in vivo clearance while maintaining good solubility. T
Autor:
Victoria Weller, Poonam Shah, David N. Mallett, Mark Price, Joanne O. Hessey, Diane M. Coe, Stephen C. Hughes, Charlotte J. Hardy, Amanda Lucas, Xiao Qing Lewell, Doug Ball, Bob H. Gibbon, Stephen A. Smith, Anesh Sitaram, Linos Lazarides, Keith Biggadike, Daphne Tsitoura, Stephen A. Hermitage, Richard Stocker, Chris D. Edwards, Mahbub Ahmed, Diana Quint, Fiona Priest, Deidre Dalmas Wilk, Aimee Hillegas, Naimisha Trivedi
Publikováno v:
Journal of medicinal chemistry. 59(5)
Induction of IFNα in the upper airways via activation of TLR7 represents a novel immunomodulatory approach to the treatment of allergic asthma. Exploration of 8-oxoadenine derivatives bearing saturated oxygen or nitrogen heterocycles in the N-9 subs
Autor:
Fiona S. Lucas, Anthony William James Cooper, Ed Robinson, Ian Robert Baldwin, Charlotte J. Hardy, Giovanni Vitulli, Suzanne Elaine Keeling, Daniel Thomas, Joelle Le, Christopher James Lunniss, Sarah Smith, Zoe Alicia Harrison, Angela M. Deakin, Augustin Amour, Stefano Livia, Stephen Barry Guntrip, Yoshiaki Washio, Leigh M. Felton, Katherine Louise Jones, Nigel J. Parr, Kenneth David Down, Paul Jones, J. Nicole Hamblin, Paul Rowland
Publikováno v:
Journal of medicinal chemistry. 58(18)
Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of clinical candidates 2 (GSK2269557) and 3 (GSK2292767) for the trea