Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Charlotte Hedskog"'
Autor:
Samuel M. Brown, Morgan J. Katz, Adit A. Ginde, Kavita Juneja, Monica Ramchandani, Joshua T. Schiffer, Carlos Vaca, Robert L. Gottlieb, Yuan Tian, Emon Elboudwarej, Joshua A. Hill, Richard Gilson, Lauren Rodriguez, Charlotte Hedskog, Shuguang Chen, Jairo M. Montezuma-Rusca, Anu Osinusi, Roger Paredes
Publikováno v:
Infectious Diseases and Therapy, Vol 12, Iss 4, Pp 1189-1203 (2023)
Abstract Introduction In the PINETREE study, early remdesivir treatment reduced risk of coronavirus disease 2019 (COVID-19)-related hospitalizations or all-cause death versus placebo by 87% by day 28 in high-risk, non-hospitalized patients. Here we r
Externí odkaz:
https://doaj.org/article/92c2e56adfd9476080f60f8837813ee7
Autor:
Charlotte Hedskog, Christoph D. Spinner, Ulrike Protzer, Dieter Hoffmann, Chunkyu Ko, Robert L. Gottlieb, Medhat Askar, Meta Roestenberg, Jutte J. C. de Vries, Ellen C. Carbo, Ross Martin, Jiani Li, Dong Han, Lauren Rodriguez, Aiyappa Parvangada, Jason K. Perry, Ricard Ferrer, Andrés Antón, Cristina Andrés, Vanessa Casares, Huldrych F. Günthard, Michael Huber, Grace A. McComsey, Navid Sadri, Judith A. Aberg, Harm van Bakel, Danielle P. Porter
Publikováno v:
Viruses, Vol 16, Iss 4, p 546 (2024)
Remdesivir (RDV) is a broad-spectrum nucleotide analog prodrug approved for the treatment of COVID-19 in hospitalized and non-hospitalized patients with clinical benefit demonstrated in multiple Phase 3 trials. Here we present SARS-CoV-2 resistance a
Externí odkaz:
https://doaj.org/article/96f39a75be5a4ab7bceddaed4be70324
Autor:
Vasily Isakov, Charlotte Hedskog, Joel O. Wertheim, Reilly E. Hostager, Bandita Parhy, Adriano De Bernardi Schneider, Vithika Suri, Hongmei Mo, Natalia Geivandova, Vyacheslav Morozov, Elena Bessonova, Natalya Gankina, Konstantin Zhdanov, Dzhamal Abdurakhmanov, Evguenia Svarovskaia
Publikováno v:
International Journal of Infectious Diseases, Vol 113, Iss , Pp 36-42 (2021)
Objectives: Due to limited hepatitis C virus (HCV) sequence availability from patients in Russia, the relationship between subtypes and baseline resistance-associated substitutions (RAS) to direct antiretroviral treatment outcome is not fully underst
Externí odkaz:
https://doaj.org/article/62204307acfa4b22ac5731f4fecfea42
Autor:
Johanna Brodin, Charlotte Hedskog, Alexander Heddini, Emmanuel Benard, Richard A Neher, Mattias Mild, Jan Albert
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119123 (2015)
Next generation sequencing technologies, like ultra-deep pyrosequencing (UDPS), allows detailed investigation of complex populations, like RNA viruses, but its utility is limited by errors introduced during sample preparation and sequencing. By taggi
Externí odkaz:
https://doaj.org/article/c4f77cd85cf84f59a3c7ad9571923346
Autor:
Johanna Brodin, Mattias Mild, Charlotte Hedskog, Ellen Sherwood, Thomas Leitner, Björn Andersson, Jan Albert
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70388 (2013)
Ultra-deep pyrosequencing (UDPS) is used to identify rare sequence variants. The sequence depth is influenced by several factors including the error frequency of PCR and UDPS. This study investigated the characteristics and source of errors in raw an
Externí odkaz:
https://doaj.org/article/4561f2c9454f42ecab7a2d083fc6ba89
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22741 (2011)
INTRODUCTION: Ultra-deep pyrosequencing (UDPS) has been used to detect minority variants within HIV-1 populations. Some aspects of the quality and reproducibility of UDPS have been previously evaluated, but comprehensive studies are still needed. PRI
Externí odkaz:
https://doaj.org/article/75210c90c0ff470990c51310627432e1
Dynamics of HIV-1 quasispecies during antiviral treatment dissected using ultra-deep pyrosequencing.
Autor:
Charlotte Hedskog, Mattias Mild, Johanna Jernberg, Ellen Sherwood, Göran Bratt, Thomas Leitner, Joakim Lundeberg, Björn Andersson, Jan Albert
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11345 (2010)
BACKGROUND: Ultra-deep pyrosequencing (UDPS) allows identification of rare HIV-1 variants and minority drug resistance mutations, which are not detectable by standard sequencing. PRINCIPAL FINDINGS: Here, UDPS was used to analyze the dynamics of HIV-
Externí odkaz:
https://doaj.org/article/e82187ed49724599a498020d2ab29f2b
Autor:
Silvia Chang, Charlotte Hedskog, Bandita Parhy, Ross Martin, Hongmei Mo, Evguenia Maiorova, Fabien Zoulim
Publikováno v:
Journal of Viral Hepatitis. 30:29-38
Antiviral nucleos(t)ide analogue therapies inhibit HBV replication and suppress the HBV DNA levels in patients with chronic HBV infection. Since HBV RNAs are expressed from cccDNA or HBV integrated sequences, independently of viral genome replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cfd76890cf8616e9df62be17e84741
https://doi.org/10.1111/jvh.13760
https://doi.org/10.1111/jvh.13760
Autor:
Richard L. Mackman, Rao Kalla, Darius Babusis, Jared Pitts, Kimberly T. Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B. Michael O’Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Elodie Dempah, Elaine Bunyan, Nicholas C. Riola, Xianghan Lu, Renmeng Liu, Ashley Davie, Tien-Ying Hsiang, Michael Gale, Anita Niedziela-Majka, Joy Y. Feng, Charlotte Hedskog, John P. Bilello, Raju Subramanian, Tomas Cihlar
Remdesivir1is an amidate prodrug that releases the monophosphate of nucleoside GS-441524 (2) into lung cells thereby forming the bioactive triphosphate2-NTP.2-NTP, an analog of ATP, inhibits the SARS-CoV-2 RNA-dependent RNA polymerase replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f124f071d22852c94170b2ccfc17e415
https://doi.org/10.1101/2023.04.28.538473
https://doi.org/10.1101/2023.04.28.538473
Autor:
Natalia Geivandova, K. V. Zhdanov, Natalya Gankina, Adriano de Bernardi Schneider, Hongmei Mo, Bandita Parhy, Reilly Hostager, Vyacheslav Morozov, Vithika Suri, D.T. Abdurakhmanov, Charlotte Hedskog, Vasily Isakov, Joel O. Wertheim, Elena Bessonova, Evguenia S. Svarovskaia
Publikováno v:
International Journal of Infectious Diseases, Vol 113, Iss, Pp 36-42 (2021)
Objectives Due to limited hepatitis C virus (HCV) sequence availability from patients in Russia, the relationship between subtypes and baseline resistance-associated substitutions (RAS) to direct antiretroviral treatment outcome is not fully understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9765cc6de54f37a0f00f2e6c19c6ae79
http://www.sciencedirect.com/science/article/pii/S1201971221007499
http://www.sciencedirect.com/science/article/pii/S1201971221007499