Haploid genetic screens identify genetic vulnerabilities to microtubule‐targeting agents

Autor: Nora M. Gerhards, Vincent A. Blomen, Merve Mutlu, Joppe Nieuwenhuis, Denise Howald, Charlotte Guyader, Jos Jonkers, Thijn R. Brummelkamp, Sven Rottenberg

Publikováno v: Molecular Oncology, Vol 12, Iss 6, Pp 953-971 (2018)

The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome‐wide loss‐of‐function screening approach in human haploid cells to characterize genetic vulnerabiliti

Externí odkaz: https://doaj.org/article/339adfac45064622b560e496f404b599

Supplementary Figures S1-S8 from Selected Alkylating Agents Can Overcome Drug Tolerance of G0-like Tumor Cells and Eradicate BRCA1-Deficient Mammary Tumors in Mice

Autor: Sven Rottenberg, Piet Borst, Jos Jonkers, Rinske Drost, Wendy Sol, Aslι Küçükosmanoğlu, Ariena Kersbergen, Maaike Gonggrijp, Charlotte Guyader, Sohvi Blatter, Marina Pajic

Figure S1: Treatment response to cisplatin spread over several days. Figure S2: Cisplatin adducts in tumor remants; GFP-marker in the BRCA1-deficient mouse model. Figure S3: EdU incorporation assay. Figure S4: Genomic profile and clonogenic assays of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7531a3c64b1329c1d24fd7cd77edd949
https://doi.org/10.1158/1078-0432.22462070

Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs

Autor: Darius Lutter, Charlotte Guyader, S. Momsen Reincke, Deborah A Elger, Felizia K. Voss, Florian Ullrich, Vincent A. Blomen, Thomas J. Jentsch, Asli Kucukosmanoglu, Sven Rottenberg, Piet Borst, Daniel J. Vis, Guotai Xu, Lodewyk F. A. Wessels, Tobias Stauber, Thijn R. Brummelkamp, Nora M. Gerhards, Rosa Planells-Cases

Publikováno v: The EMBO journal, 34(24): 2985-3073
The EMBO Journal
EMBO Journal, 34(24), 2993-3008. Wiley-Blackwell
ResearcherID
Planells-Cases, Rosa; Lutter, Darius; Guyader, Charlotte; Gerhards, Nora Merete; Ullrich, Florian; Elger, Deborah A; Kucukosmanoglu, Asli; Xu, Guotai; Voss, Felizia K; Reincke, S Momsen; Stauber, Tobias; Blomen, Vincent A; Vis, Daniel J; Wessels, Lodewyk F; Brummelkamp, Thijn R; Borst, Piet; Rottenberg, Sven; Jentsch, Thomas J (2015). Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. The EMBO Journal, 34(24), pp. 2993-3008. EMBO Press 10.15252/embj.201592409
Planells-Cases, R, Lutter, D, Guyader, C, Gerhards, N M, Ullrich, F, Elger, D A, Kucukosmanoglu, A, Xu, G, Voss, F K, Reincke, S M, Stauber, T, Blomen, V A, Vis, D J, Wessels, L F, Brummelkamp, T R, Borst, P, Rottenberg, S & Jentsch, T J 2015, ' Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs ', EMBO Journal, vol. 34, no. 24, pp. 2993-3008 . https://doi.org/10.15252/embj.201592409
EMBO JOURNAL

Although platinum‐based drugs are widely used chemotherapeutics for cancer treatment, the determinants of tumor cell responsiveness remain poorly understood. We show that the loss of subunits LRRC8A and LRRC8D of the heteromeric LRRC8 volume‐regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a24fce2d0a948aa4340f62de1d8b6aa
http://www.scopus.com/inward/record.url?scp=84955178178&partnerID=8YFLogxK

Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents

Autor: Jos Jonkers, Merve Mutlu, Charlotte Guyader, Thijn R. Brummelkamp, Sven Rottenberg, Denise Howald, Vincent A. Blomen, Nora M. Gerhards, Joppe Nieuwenhuis

Publikováno v: Molecular Oncology
Molecular Oncology, Vol 12, Iss 6, Pp 953-971 (2018)
Gerhards, Nora Merete; Blomen, Vincent A; Mutlu, Merve; Nieuwenhuis, Joppe; Howald, Denise; Guyader, Charlotte; Jonkers, Jos; Brummelkamp, Thijn R; Rottenberg, Sven (2018). Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents. Molecular oncology, 12(6), pp. 953-971. Elsevier 10.1002/1878-0261.12307

The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome-wide loss-of-function screening approach in human haploid cells to characterize genetic vulnerabilities to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469cfb7d48c71430004cdfc1c21dc06d
https://pubmed.ncbi.nlm.nih.gov/29689640

Hormone escape is associated with genomic instability in a human prostate cancer model

Autor: Marie-Emmanuelle Legrier, Charlotte Guyader, Jocelyn Céraline, Nathalie Auger, Marie-France Poupon, Bernard Dutrillaux, Stéphane Oudard

Publikováno v: International Journal of Cancer. 124:1103-1111

Lack of hormone dependency in prostate cancers is an irreversible event that occurs through generation of genomic instability induced by androgen deprivation. Indeed, the cytogenetic profile of hormone-dependent (HD) prostate cancer remains stable as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038243529f570f2507d44ff0a44fce5f
https://doi.org/10.1002/ijc.24073