The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects: an interventional, randomized, double-blind, parallel-group, placebo-controlled study

Autor: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin, Messoud Ashina

Publikováno v: The Journal of Headache and Pain, Vol 24, Iss 1, Pp 1-12 (2023)

Abstract Background Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate cranial arteries and

Externí odkaz: https://doaj.org/article/4dfc293839ef4ff2a2c47095f529d23c

The effect of Lu AG09222 on PACAP38- and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects:an interventional, randomized, double-blind, parallel-group, placebo-controlled study

Autor: Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin, Messoud Ashina

Publikováno v: Rasmussen, N B, Deligianni, C, Christensen, C E, Karlsson, W K, Al-Khazali, H M, Van de Casteele, T, Granhall, C, Amin, F M & Ashina, M 2023, ' The effect of Lu AG09222 on PACAP38-and VIP-induced vasodilation, heart rate increase, and headache in healthy subjects : an interventional, randomized, double-blind, parallel-group, placebo-controlled study ', Journal of Headache and Pain, vol. 24, 60 . https://doi.org/10.1186/s10194-023-01599-w

Background Pituitary adenylate cyclase-activating polypeptide (PACAP), structurally related to vasoactive intestinal peptide (VIP), is one of the important mediators in the pathogenesis of migraine and is known to dilate cranial arteries and induce h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4625d048f552fee3e0b0cd0b1fcc0d33
https://curis.ku.dk/portal/da/publications/the-effect-of-lu-ag09222-on-pacap38-and-vipinduced-vasodilation-heart-rate-increase-and-headache-in-healthy-subjects(d54fcc1c-e0c3-4376-b8bc-661e4d63ecd4).html

Author response for 'Effect of upper gastrointestinal disease on the pharmacokinetics of oral semaglutide in subjects with type 2 diabetes'

Autor: null Juris J. Meier, null Charlotte Granhall, null Ulrike Hoevelmann, null Andrea Navarria, null Leona Plum‐Moerschel, null Chethana Ramesh, null Andrea Tannapfel, null Christoph Kapitza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e7094bb2c3e95b57dba93a1d767520c
https://doi.org/10.1111/dom.14632/v2/response1

Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects with Renal Impairment

Autor: Mette Thomsen, Charlotte Granhall, Flemming L. Søndergaard, Thomas W. Anderson

Publikováno v: Clinical Pharmacokinetics

Background Semaglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been co-formulated with the absorption enhancer sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) as a tablet for oral administration. This trial (NCT02014259) investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba7b74f00995d4c252023564b26f554
http://europepmc.org/articles/PMC6267549

Oral Semaglutide Does Not Affect the Bioavailability of the Combined Oral Contraceptive Ethinylestradiol/Levonorgestrel

Autor: Erik Christiansen, Astrid Breitschaft, Cilie W. Hansen, Tine A. Bækdal, Charlotte Granhall, Andreas Børsting Jordy, Azadeh Houshmand-Oregaard

Publikováno v: Diabetes. 67

Semaglutide is a glucagon-like peptide (GLP-1) analog co-formulated with the absorption enhancer, sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC), to allow oral administration. The effect of oral semaglutide on the pharmacokinetics (PK) of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::759dea84b75d2c0e1e21494ef68f315d
https://doi.org/10.2337/db18-1135-p