Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response

Autor: Franziska Gsottberger, Christina Meier, Anna Ammon, Scott Parker, Kerstin Wendland, Rebekka George, Srdjan Petkovic, Lisa Mellenthin, Charlotte Emmerich, Gloria Lutzny-Geier, Markus Metzler, Andreas Mackensen, Vidyalakshmi Chandramohan, Fabian Müller

Publikováno v: Cell Death and Disease, Vol 14, Iss 8, Pp 1-13 (2023)

Abstract Cellular stress responses including the unfolded protein response (UPR) decide over the fate of an individual cell to ensure survival of the entire organism. During physiologic UPR counter-regulation, protective proteins are upregulated to p

Externí odkaz: https://doaj.org/article/15b35ae762b44e4bbd9c25c7e5e42184

Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments

Autor: Charlotte Emmerich, Carol Geppert, Ramona Erber, Fabian Müller, Franziska Gsottberger, Arndt Hartmann, Kerstin Wendland, Srdjan Petkovic, Lars Nitschke, Andreas Mackensen, Carolin Brandl

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 10433, p 10433 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 19

Targeted immunotherapies have greatly changed treatment of patients with B cell malignancies. To further enhance immunotherapies, research increasingly focuses on the tumor microenvironment (TME), which differs considerably by organ site. However, im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ac128646382f0c4721860f1b7cbec7
https://www.mdpi.com/1422-0067/22/19/10433

Myc-Driven, Primary Mouse Lymphoma Expressing Human CD22 Are Highly Infiltrated By Syngeneic Immune Cells and Provide a Unique Model to Test CD22-Targeted Therapies

Autor: Lars Nitschke, Carolin Brandl, Fabian Müller, Charlotte Emmerich, Andreas Mackensen, Franziska Wagner

Publikováno v: Blood. 132:1673-1673

Background: CD22 has emerged as an attractive target for the treatment of B-cell malignancies because (i) CD22 shows high surface expression on most mature and precursor B-cell malignancies, (ii) it is rapidly internalized after ligand binding, and (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3c6db7140af90b59deea11a5c4e0239
https://doi.org/10.1182/blood-2018-99-110284