Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Charlotte E. Johnson"'
Autor:
Henry D. McCann, Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop, Andrew R. Tee
Publikováno v:
Cancers, Vol 10, Iss 10, p 375 (2018)
To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mef
Externí odkaz:
https://doaj.org/article/05b44a71a37043bcb028a1fc33b65b81
Autor:
Samantha D M Arras, Taylor R Hibbard, Lucy Mitsugi-McHattie, Matthew A Woods, Charlotte E Johnson, Andrew Munkacsi, Sylvie Hermann-Le Denmat, Austen R D Ganley
Publikováno v:
FEMS yeast research. 22(1)
Saccharomyces cerevisiae is an exceptional genetic system, with genetic crosses facilitated by its ability to be maintained in haploid and diploid forms. Such crosses are straightforward if the mating type/ploidy of the strains are known. Several tec
Autor:
Charlotte E. Johnson, Andrew R. Tee
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) at lysosomes plays a pivotal role in cell growth control where an array of large multiprotein complexes relay nutrient, energy, and growth signal inputs through mTORC1. In cancer cells, such r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d0810d79f2bc9c643bb5c128b7a1d3
Autor:
David K. Hunt, Julian R. Sampson, Terry P. Herbert, D. Mark Davies, Rachel J. Errington, Marie Wiltshire, Andrew R. Tee, Charlotte E. Johnson
Publikováno v:
Molecular Oncology. 9:675-688
Inappropriate activation of mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is common in cancer and has many cellular consequences including elevated endoplasmic reticulum (ER) stress. Cells employ autophagy as a critical compensatory su
Autor:
Charlotte E. Johnson, Elaine A. Dunlop, Sara Seifan, Henry D. McCann, Trevor Hay, Geraint J. Parfitt, Ashley T. Jones, Peter J. Giles, Ming H. Shen, Julian R. Sampson, Rachel J. Errington, D. Mark Davies, Andrew R. Tee
Publikováno v:
Oncogene. 38:3102-3102
This article was originally published under standard licence, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly.
Autor:
Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop, Andrew R. Tee, Henry D. McCann
Publikováno v:
Cancers, Vol 10, Iss 10, p 375 (2018)
Cancers; Volume 10; Issue 10; Pages: 375
Cancers
Cancers; Volume 10; Issue 10; Pages: 375
Cancers
To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mef
Autor:
Sudhir Tauro, Alan R. Prescott, Michael J. Groves, Ian G. Ganley, John James, Chris Pepper, Joan Cunningham, Lisa Pirrie, Nicholas J. Westwood, Philip J. Coates, Sally Haydock, Christopher Fegan, Charlotte E. Johnson
Publikováno v:
British Journal of Cancer
Background: Activation of wild-type p53 with the small molecule sirtuin inhibitor Tenovin-6 (Tnv-6) induces p53-dependent apoptosis in many malignant cells. In contrast, Tnv-6 reduces chronic lymphocytic leukaemia (CLL) cell viability with dysregulat