Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Charlotte E, Farquhar"'
Autor:
Chengxi Li, Alex J. Callahan, Kruttika S. Phadke, Bryan Bellaire, Charlotte E. Farquhar, Genwei Zhang, Carly K. Schissel, Alexander J. Mijalis, Nina Hartrampf, Andrei Loas, David E. Verhoeven, Bradley L. Pentelute
Publikováno v:
ACS Central Science, Vol 8, Iss 2, Pp 205-213 (2021)
Externí odkaz:
https://doaj.org/article/4cacfea2bd9d40439c92d254f7ca4bea
Autor:
Martin Gazvoda, Heemal H. Dhanjee, Jacob Rodriguez, Joseph S. Brown, Charlotte E. Farquhar, Nicholas L. Truex, Andrei Loas, Stephen L. Buchwald, Bradley L. Pentelute
Publikováno v:
J Am Chem Soc
Carboranes represent a class of compounds with increasing therapeutic potential. However, few general approaches to readily embed carboranes into small molecules, peptides, and proteins are available. We report a strategy based on palladium-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bcfc51860c1413c58e0d4a56318c6c
https://doi.org/10.1021/jacs.2c01932
https://doi.org/10.1021/jacs.2c01932
An expansion of the hexanucleotide (GGGGCC) repeat sequence in the chromosome 9 open frame 72 (c9orf72) is the most common genetic mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mutation leads to the production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5067b817be9b9aa9cbf9a29ec9a40f38
https://doi.org/10.26434/chemrxiv-2023-17b15
https://doi.org/10.26434/chemrxiv-2023-17b15
Autor:
Carly K. Schissel, Charlotte E. Farquhar, Andrei Loas, Annika B. Malmberg, Bradley L. Pentelute
Peptide-mediated delivery of macromolecules in cells has significant potential therapeutic benefits, but no therapy employing cell-penetrating peptides (CPPs) has reached the market after 30 years of investigation due to challenges in the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d34cd22003f7c2b1c6c011dcd980ec3
https://doi.org/10.1101/2022.04.13.488231
https://doi.org/10.1101/2022.04.13.488231
Autor:
Charlotte E. Farquhar, Sebastian Pomplun, Carly K. Schissel, Adeline Marie Schmitt, Christopher R. Shugrue, Bradley L. Pentelute
Publikováno v:
Angew Chem Int Ed Engl
Prof. Pentelute via Ye Li
Prof. Pentelute via Ye Li
Capture and release of peptides is often a critical operation in the pathway to discovering materials with novel functions. However, the best methods for efficient capture impede facile release. To overcome this challenge, we report linkers based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9eebc17bbe1f0cfe939a2fdcae0a43
https://doi.org/10.1002/anie.202003478
https://doi.org/10.1002/anie.202003478
Autor:
Charlotte E. Farquhar, Chengxi Li, Kruttika S. Phadke, Carly K. Schissel, Alexander J. Mijalis, Genwei Zhang, Bryan H. Bellaire, Nina Hartrampf, David Verhoeven, Bradley L. Pentelute, Andrei Loas, Alex J. Callahan
Antisense peptide nucleic acids (PNAs) have yet to translate to the clinic because of poor cellular uptake, limited solubility, and rapid elimination. Cell-penetrating peptides (CPPs) covalently attached to PNAs may facilitate clinical development by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dffb069f3569d59cf55d0c7503e4fe5
https://www.zora.uzh.ch/id/eprint/215612/
https://www.zora.uzh.ch/id/eprint/215612/
Autor:
Martin Gazvoda, Heemal H. Dhanjee, Jacob Rodriguez, Joseph S. Brown, Charlotte E. Farquhar, Nicholas L. Truex, Andrei Loas, Stephen L. Buchwald, Bradley L. Pentelute
Publikováno v:
Journal of the American Chemical Society. 144:10096-10096
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5d16346048afdd106992eb91f2a9e1
https://doi.org/10.1021/jacs.2c04948
https://doi.org/10.1021/jacs.2c04948
Autor:
Jenny L, Wiley, Daniel G, Barrus, Charlotte E, Farquhar, Timothy W, Lefever, Thomas F, Gamage
Publikováno v:
Prog Neuropsychopharmacol Biol Psychiatry
Cannabis edibles are becoming more common in an increasingly diverse population of users, and the impact of first pass metabolism on cannabis’s pharmacological profile across age and sex is not well understood. The present study examined the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc38ab91aa13a99a7d068b1cc84b4739
https://pubmed.ncbi.nlm.nih.gov/32810571
https://pubmed.ncbi.nlm.nih.gov/32810571
Autor:
Thuy Nguyen, Jenny L. Wiley, Yanan Zhang, Tiffany L. Langston, Ann M. Decker, Terrence Peter Kenakin, Charlotte E. Farquhar, Brian F. Thomas, Thomas F. Gamage, Nadezhda German
Publikováno v:
ACS Chemical Neuroscience. 10:518-527
Allosteric modulators have attracted significant interest as an alternate strategy to modulate CB1 receptor signaling for therapeutic benefits that may avoid the adverse effects associated with orthosteric ligands. Here we extended our previous struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaf5a42846e6c8ead52eea9d09ca4bd6
https://doi.org/10.1021/acschemneuro.8b00396
https://doi.org/10.1021/acschemneuro.8b00396
Autor:
Thuy Nguyen, Charlotte E. Farquhar, Yanan Zhang, Timothy W. Lefever, Jenny L. Wiley, Brian F. Thomas, Thomas F. Gamage
Publikováno v:
Neuropharmacology. 125:365-375
While allosteric modulators of the cannabinoid type-1 receptor (CB1) continue to be developed and characterized, the gap between the in vitro and in vivo data is widening, raising questions regarding translatability of their effects and biological re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0a54cb64af3190842085ebe70ccfb7
https://doi.org/10.1016/j.neuropharm.2017.08.008
https://doi.org/10.1016/j.neuropharm.2017.08.008