Výsledky vyhledávání - "Charlotte Demkes"

Postnatal Cardiac Gene Editing Using CRISPR/Cas9 With AAV9-Mediated Delivery of Short Guide RNAs Results in Mosaic Gene Disruption

Autor: Charlotte Demkes, Mauro Giacca, Bastiaan Spanjaard, Farhad Akbari Moqadam, Lieneke Kooijman, Hesther de Ruiter, Lorena Zentilin, D Versteeg, Bas Molenaar, Anne Katrine Johansen, Eva van Rooij, Ana Rita Leitoguinho

Publikováno v: Circulation Research, 121(10), 1168-1181. Lippincott Williams & Wilkins

Rationale: CRISPR/Cas9 (clustered regularly interspaced palindromic repeats/CRISPR-associated protein 9)–based DNA editing has rapidly evolved as an attractive tool to modify the genome. Although CRISPR/Cas9 has been extensively used to manipulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb66c30d26a595eda1fb2d3c95d584e3
https://doi.org/10.1161/circresaha.116.310370

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Abstract 262: Gene Expression Profiling of Hypertrophic and Failing Cardiomyocytes Identifies New Players Involved in Heart Failure

Autor: Folkert W. Asselbergs, J. E. C. Eding, Aryan Vink, Danielle Versteeg, Monika M Gladka, Marta Vigil-Garcia, Alex Bossu, Charlotte Demkes, Eva van Rooij, Magdalena Harakalova, Hesther de Ruiter, Toon A.B. van Veen

Publikováno v: Circulation Research. 125

Pathological remodeling during cardiac disease is a detrimental response characterized by cardiomyocyte hypertrophy and fibroblast activation, which can ultimately lead to heart failure. Genome wide expression analysis on full heart tissue have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d63bc19db88c27d83a1d5fd94b0cd866
https://doi.org/10.1161/res.125.suppl_1.262

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Abstract 19: Microrna-19b Enhances Cardiac Cell Survival After Ischemic Injury

Autor: Bas Molenaar, Charlotte Demkes, Hester Ruiter, de, Danielle Versteeg, Monika Gladka-de Vries, Ricardo Korporaal, Else Deel, van, Hillary M Semus, Eva van Rooij

Publikováno v: Circulation Research. 117

Ischemia/reperfusion (I/R) injury in cardiac tissue results in substantial loss of cardiomyocytes, leading to a functional decline. The release of several cytokines increases cardiomyocyte survival after ischemic injury by activating the janus kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4e8a207aed3e9f7ac01ec3259ae19a3
https://doi.org/10.1161/res.117.suppl_1.19

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