Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Charlotte Deane"'
Autor:
Alfredo Iacoangeli, Paolo Marcatili, Charlotte Deane, Arthur M. Lesk, Annalisa Pastore, Sarah A. Teichmann
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/5941280af92d4dad8a160c19df5c2c95
Autor:
Saulo de Oliveira, Charlotte Deane
Publikováno v:
F1000Research, Vol 6 (2017)
Co-evolution techniques were originally conceived to assist in protein structure prediction by inferring pairs of residues that share spatial proximity. However, the functional relationships that can be extrapolated from co-evolution have also proven
Externí odkaz:
https://doaj.org/article/8b8c2620755844549293cdc9d23597d5
Publikováno v:
Evolutionary Bioinformatics, Vol 4, Pp 203-216 (2008)
β-propeller domains composed of WD repeats are highly ubiquitous and typically used as multi-site docking platforms to coordinate and integrate the activities of groups of proteins. Here, we have used extensive homology modelling of the WD40-repeat
Externí odkaz:
https://doaj.org/article/db06d8e1951646e98e62d18f5282dc30
Autor:
James M Osborne, Miguel O Bernabeu, Maria Bruna, Ben Calderhead, Jonathan Cooper, Neil Dalchau, Sara-Jane Dunn, Alexander G Fletcher, Robin Freeman, Derek Groen, Bernhard Knapp, Greg J McInerny, Gary R Mirams, Joe Pitt-Francis, Biswa Sengupta, David W Wright, Christian A Yates, David J Gavaghan, Stephen Emmott, Charlotte Deane
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003506 (2014)
Externí odkaz:
https://doaj.org/article/7e501827514d4598aa43b6895de6034c
Autor:
Julian R Hughes, Ana M Meireles, Katherine H Fisher, Angel Garcia, Philip R Antrobus, Alan Wainman, Nicole Zitzmann, Charlotte Deane, Hiroyuki Ohkura, James G Wakefield
Publikováno v:
PLoS Biology, Vol 6, Iss 4, p e98 (2008)
The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associated pro
Externí odkaz:
https://doaj.org/article/c4838029fa1c4a1d88aa8e3272f35393
Publikováno v:
Nucleic Acids Research
In 2013, we released the Structural Antibody Database (SAbDab), a publicly available repository of experimentally determined antibody structures. In the interim, the rapid increase in the number of antibody structure depositions to the Protein Data B
Protein representations from deep language models have yielded state-of-the-art performance across many tasks in computational protein engineering. In recent years, progress has primarily focused on parameter count, with recent models’ capacities s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dfaabbef62b751ba3519acc44b0f2b4
https://doi.org/10.1101/2022.12.15.519894
https://doi.org/10.1101/2022.12.15.519894
Antibodies with similar amino acid sequences, especially across their complementary-determining regions, often share properties. Finding that an antibody of interest has a similar sequence to naturally expressed antibodies in healthy or diseased repe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d80c5cab5b70ef439c6ca162623f270f
https://doi.org/10.1101/2022.11.01.513855
https://doi.org/10.1101/2022.11.01.513855
T-cell receptor-mimetic antibodies (TCRms) targeting disease-associated peptides presented by Major Histocompatibility Complexes (pMHCs) are set to become a major new drug modality. However, we lack a general understanding of how TCRms engage pMHC ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db540a06c8d64f64bcf68631982bfa4b
https://doi.org/10.1101/2022.07.15.500208
https://doi.org/10.1101/2022.07.15.500208
Current fragment-based drug design relies on the efficient exploration of chemical space though the use of structurally diverse libraries of small fragments. However, structurally dissimilar compounds can exploit the same interactions on a target, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62777dcd3bc5c5f237ea9faf9422ce88
https://doi.org/10.1101/2022.03.18.484642
https://doi.org/10.1101/2022.03.18.484642