Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Charlotte D Eaton"'
MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features
Autor:
Charlotte D. Eaton, Lauro Avalos, S. John Liu, Zhenhong Chen, Naomi Zakimi, Tim Casey-Clyde, Paola Bisignano, Calixto-Hope G. Lucas, Erica Stevenson, Abrar Choudhury, Harish N. Vasudevan, Stephen T. Magill, Jacob S. Young, Nevan J. Krogan, Javier E. Villanueva-Meyer, Danielle L. Swaney, David R. Raleigh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Meningiomas are associated with inactivation of NF2/Merlin, but approximately one-third of meningiomas with favorable clinical outcomes retain Merlin expression. Biochemical mechanisms underlying Merlin-intact meningioma growth are incomplet
Externí odkaz:
https://doaj.org/article/09cad89a882942b286e00cb8af45c58a
Autor:
S. John Liu, Tim Casey-Clyde, Nam Woo Cho, Jason Swinderman, Melike Pekmezci, Mark C. Dougherty, Kyla Foster, William C. Chen, Javier E. Villanueva-Meyer, Danielle L. Swaney, Harish N. Vasudevan, Abrar Choudhury, Joanna Pak, Jonathan D. Breshears, Ursula E. Lang, Charlotte D. Eaton, Kamir J. Hiam-Galvez, Erica Stevenson, Kuei-Ho Chen, Brian V. Lien, David Wu, Steve E. Braunstein, Penny K. Sneed, Stephen T. Magill, Daniel Lim, Michael W. McDermott, Mitchel S. Berger, Arie Perry, Nevan J. Krogan, Marlan R. Hansen, Matthew H. Spitzer, Luke Gilbert, Philip V. Theodosopoulos, David R. Raleigh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mechanisms specifying cancer cell states and response to therapy are incompletely understood. Here we show epigenetic reprogramming shapes the cellular landscape of schwannomas, the most common tumors of the peripheral nervous system. We fin
Externí odkaz:
https://doaj.org/article/6c3cb10a1a664ce0a55f363c96e7591d
Autor:
Harish N. Vasudevan, Emily Payne, Cyrille L. Delley, S. John Liu, Kanish Mirchia, Matthew J. Sale, Sydney Lastella, Maria Sacconi Nunez, Calixto-Hope G. Lucas, Charlotte D. Eaton, Tim Casey-Clyde, Stephen T. Magill, William C. Chen, Steve E. Braunstein, Arie Perry, Line Jacques, Alyssa T. Reddy, Melike Pekmezci, Adam R. Abate, Frank McCormick, David R. Raleigh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Schwann cell tumors are the most common cancers of the peripheral nervous system and can arise in patients with neurofibromatosis type-1 (NF-1) or neurofibromatosis type-2 (NF-2). Functional interactions between NF1 and NF2 and broader mecha
Externí odkaz:
https://doaj.org/article/a34dc09304394fd3ae1c29c108fd0bbd
Autor:
Abrar Choudhury, Stephen T. Magill, Charlotte D. Eaton, Briana C. Prager, William C. Chen, Martha A. Cady, Kyounghee Seo, Calixto-Hope G. Lucas, Tim J. Casey-Clyde, Harish N. Vasudevan, S. John Liu, Javier E. Villanueva-Meyer, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Danielle L. Swaney, Michael Y. Zhang, Jason W. Chan, Zhixin Qiu, Michael V. Martin, Matthew S. Susko, Steve E. Braunstein, Nancy Ann Oberheim Bush, Jessica D. Schulte, Nicholas Butowski, Penny K. Sneed, Mitchel S. Berger, Nevan J. Krogan, Arie Perry, Joanna J. Phillips, David A. Solomon, Joseph F. Costello, Michael W. McDermott, Jeremy N. Rich, David R. Raleigh
Publikováno v:
Nature genetics, vol 54, iss 5
Nat Genet
Nat Genet
Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been encumbered by limited understanding of meningioma biology. Here, we use DNA methylation profil
Autor:
Eline Hendrix, Regina Andrijes, Uncaar Boora, Arashpreet Kaur, James R Bundred, Adam Zayer, Raphael Heilig, Christian A E Westrip, Sally C Fletcher, Charlotte D Eaton, Tristan J Kennedy, Sonia Piasecka, Roman Fischer, Stephen J Smerdon, Mathew L Coleman
Jumonji-C (JmjC) ribosomal protein hydroxylases are an ancient class of oxygen- and Fe(II)-dependent oxygenases that spawned the wider JmjC family and Histone Lysine Demethylases (KDMs) in eukaryotes. Myc-induced Antigen (MINA) has been implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f159e5a93b4dbbc78482ca07682b589
https://doi.org/10.1101/2023.03.15.532818
https://doi.org/10.1101/2023.03.15.532818
Autor:
S. John Liu, Tim Casey-Clyde, Nam Woo Cho, Jason Swinderman, Melike Pekmezci, Mark C. Dougherty, Kyla Foster, William C. Chen, Javier E. Villanueva-Meyer, Danielle L. Swaney, Harish N. Vasudevan, Abrar Choudhury, Jonathan D. Breshears, Ursula E. Lang, Charlotte D Eaton, Kamir J. Hiam-Galvez, Erica Stevenson, Kuei-Ho Chen, Brian V. Lien, David Wu, Steve E. Braunstein, Penny K. Sneed, Stephen T. Magill, Daniel Lim, Michael W. McDermott, Mitchel S. Berger, Arie Perry, Nevan J. Krogan, Marlon Hansen, Matthew H. Spitzer, Luke Gilbert, Philip V. Theodosopoulos, David R. Raleigh
SummaryCell state evolution underlies tumor development and response to therapy1, but mechanisms specifying cancer cell states and intratumor heterogeneity are incompletely understood. Schwannomas are the most common tumors of the peripheral nervous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc6f1b4185d7958479e36fb130929ae6
https://doi.org/10.1101/2022.12.23.521842
https://doi.org/10.1101/2022.12.23.521842
Autor:
Minh P Nguyen, Kyounghee Seo, Charlotte D Eaton, Calixto-Hope G Lucas, William C Chen, Abrar Choudhury, Jacob S Young, David R Raleigh
Publikováno v:
Neuro-oncology advances. 4(1)
Autor:
Abrar Choudhury, Stephen T. Magill, Charlotte D. Eaton, Briana C. Prager, William C. Chen, Kyounghee Seo, Calixto-Hope G. Lucas, Javier E. Villanueva-Meyer, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Harish N. Vasudevan, S. John Liu, Jason W. Chan, Zhixin Qiu, Michael Y. Zhang, Michael V. Martin, Matthew S. Susko, Steve E. Braunstein, Nancy Ann Oberheim Bush, Jessica Schulte, Nicholas Butowski, Penny K. Sneed, Mitchel S. Berger, Arie Perry, Joanna J. Phillips, David A. Solomon, Joseph F. Costello, Michael W. McDermott, Jeremy N. Rich, David R. Raleigh
SUMMARYMeningiomas arising from the meningothelial central nervous system lining are the most common primary intracranial tumors, and a significant cause of neurologic morbidity and mortality1. There are no effective medical therapies for meningioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::095a68adc866805ada6d7e17b4bf6510
https://doi.org/10.1101/2020.11.23.20237495
https://doi.org/10.1101/2020.11.23.20237495
Autor:
Pablo Wappner, Helen E McNeil, Robert K. Leśniak, Martine I. Abboud, Wei Ge, Rasheduzzaman Chowdhury, Simon J. Davis, Charlotte A. Hall, Weston B. Struwe, Ming Yang, Rebecca Konietzny, Peter J. Ratcliffe, Christopher J. Schofield, Sarah E. Wilkins, Charlotte D. Eaton, Roman Fischer, Suzana Markolovic, Maximiliano Javier Katz, Qinqin Zhuang, Justin L. P. Benesch, Benedikt M. Kessler, Mathew L. Coleman, Matthew E. Cockman
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nature chemical biology
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nature chemical biology
Biochemical, structural and cellular studies reveal Jumonji-C (JmjC) domain-containing 7 (JMJD7) to be a 2-oxoglutarate (2OG)-dependent oxygenase that catalyzes (3S)-lysyl hydroxylation. Crystallographic analyses reveal JMJD7 to be more closely relat
Autor:
Helen E McNeil, Rebecca Konietzny, Suzana Markolovic, Charlotte D. Eaton, Martine I. Abboud, Wei Ge, Pablo Wappner, Qinqin Zhuang, Charlotte A. Hall, Simon J. Davis, Weston B. Struwe, Mathew L. Coleman, Benedikt M. Kessler, Benesch Jlp., Roman Fischer, Peter J. Ratcliffe, Robert K. Leśniak, Ming Yang, Sarah E. Wilkins, Marie Katz, Rasheduzzaman Chowdhury, Christopher J. Schofield, Matthew E. Cockman
Publikováno v:
Nature Chemical Biology. 14:988-988
In the version of this article initially published, authors Sarah E. Wilkins, Charlotte D. Eaton, Martine I. Abboud and Maximiliano J. Katz were incorrectly included in the equal contributions footnote in the affiliations list. Footnote number seven