Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Charlotte Courageux"'
Autor:
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon
Publikováno v:
Biomolecules, Vol 10, Iss 6, p 858 (2020)
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholineste
Externí odkaz:
https://doaj.org/article/c8ad1bdb8ca0419e90bec0584f145514
Autor:
Ophélie Da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, Caroline Coisne, André-Guilhem Calas, Fabien Gosselet, Charlotte Courageux, Anne-Julie Gastellier, Marilène Trancart, Rachid Baati, Marie-Pierre Dehouck, Ludovic Jean, Florian Nachon, Pierre-Yves Renard, José Dias
Publikováno v:
Journal of medicinal chemistry. 65(6)
Recent events demonstrated that organophosphorus nerve agents are a serious threat for civilian and military populations. The current therapy includes a pyridinium aldoxime reactivator to restore the enzymatic activity of acetylcholinesterase located
Autor:
Pascale Leroy, Chamseddine Ben Brahim, Charlotte Courageux, Pierre de la Grange, Ariane Jolly
Publikováno v:
Molecular Biology Reports. 48:6729-6738
Basal stem/progenitor cells of airway epithelium from chronic obstructive pulmonary disease (COPD) patients have a decrease in differentiation and self-renewal potential. Our study aimed at identifying deregulations in the genetic program of these ce
Autor:
Florian Nachon, Xavier Brazzolotto, José Dias, Charlotte Courageux, Wojciech Drożdż, Xiao‐Yu Cao, Artur R. Stefankiewicz, Jean‐Marie Lehn
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(23)
We report the implementation of coordination complexes containing two types of cationic moieties, i. e. pyridinium and ammonium quaternary salt, as potential inhibitors of human cholinesterase enzymes. Utilization of ligands containing NNO-coordinati
Autor:
Florian Nachon, Franck Razafindrainibe, Mallikajurna Reddy Nimmakayala, Jagadeesh Yerri, Charlotte Courageux, Rachid Baati, Marie-Pierre Dehouck, Caroline Coisne, Johan Hachani, Christophe Landry, José A. Dias, Johanne Jegoux, Anne-Julie Gastellier, Jean-François Goossens, Fabien Gosselet
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, 2020, 26 (65), pp.15035-15044. ⟨10.1002/chem.202002012⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (65), pp.15035-15044. ⟨10.1002/chem.202002012⟩
Chemistry-A European Journal, 2020, 26 (65), pp.15035-15044. ⟨10.1002/chem.202002012⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (65), pp.15035-15044. ⟨10.1002/chem.202002012⟩
International audience; Novel 6-alkyl- and 6-alkenyl-3-fluoro-2-pyridinaldoximes have been synthesised by using a mild and efficient chemoselective hydrogenation of 6-alkynyl-3-fluoro-2-pyridinaldoxime scaffolds, without altering the reducible, unpro
Autor:
Jared A. Miles, Jia Hui Ng, B. Yogi Sreenivas, Charlotte Courageux, Alexandre Igert, José Dias, Ross P. McGeary, Xavier Brazzolotto, Benjamin P. Ross
Publikováno v:
Chemical Biology & Drug Design. 97
Autor:
Pierre, de la Grange, Ariane, Jolly, Charlotte, Courageux, Chamseddine, Ben Brahim, Pascale, Leroy
Publikováno v:
Molecular biology reports. 48(10)
Basal stem/progenitor cells of airway epithelium from chronic obstructive pulmonary disease (COPD) patients have a decrease in differentiation and self-renewal potential. Our study aimed at identifying deregulations in the genetic program of these ce
Autor:
Bérengère Ouine, Pierre de la Grange, Leanne de Koning, Chamseddine Ben Brahim, Aurélie Cartier, Charlotte Courageux, Pascale Leroy, Ariane Jolly
Publikováno v:
Stem cell reviews and reports. 17(3)
Slug/Snail2 belongs to the Epithelial-Mesenchymal Transition (EMT)-inducing transcription factors involved in development and diseases. Slug is expressed in adult stem/progenitor cells of several epithelia, making it unique among these transcription
Autor:
Ross P. McGeary, Charlotte Courageux, José A. Dias, Jia Hui Ng, Alexandre Igert, Benjamin P. Ross, Jared A. Miles, Xavier Brazzolotto, B. Yogi Sreenivas
Publikováno v:
Chemical biologydrug designREFERENCES. 97(5)
Cholinesterase inhibitors remain the mainstay of Alzheimer's disease treatment, and the search for new inhibitors with better efficacy and side effect profiles is ongoing. Virtual screening (VS) is a powerful technique for searching large compound da
Autor:
José A. Dias, Tereza Kobrlova, Vendula Hepnarova, Tomas Kucera, Daniel Jun, Lubica Muckova, Florian Nachon, David Malinak, Jan Korabecny, Kamil Musilek, Franz Worek, Martina Hrabinova, Lukas Gorecki, Ondrej Soukup, Charlotte Courageux, Jana Zdarova Karasova, Lukas Prchal
Publikováno v:
Archives of toxicology. 95(3)
To date, the only treatments developed for poisoning by organophosphorus compounds, the most toxic chemical weapons of mass destruction, have exhibited limited efficacy and versatility. The available causal antidotes are based on reactivation of the