ChemInform Abstract: Rhodium-Catalyzed 1,4-Addition of Arylboronic Acids to 3-Benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Derivatives

Autor: Cécile Croix, Marie-Claude Viaud-Massuard, Gildas Prie, Charlotte Chaulet

Publikováno v: ChemInform. 46

7-Azaindoles are versatile building blocks, especially in medicinal chemistry, where they serve as bioisosteres of indoles or purines. Herein, we present a novel rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6af9a70ecca109cfc114c8e868b5840
https://doi.org/10.1002/chin.201531208

Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors

Autor: Cécile Croix, Marie-Claude Viaud-Massuard, David Alagille, Adriana Delwail, Sylvain Normand, Laure Favot, Charlotte Chaulet, Jean-Claude Lecron

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2011, 21 (3), pp.1019-1022. ⟨10.1016/j.bmcl.2010.12.031⟩

International audience; Several thalidomide analogues were synthesized and compared to thalidomide and its more active analogue, lenalidomide, for their ability to inhibit the production of the pro-inflammatory cytokine tumour necrosis factor (TNF)-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c94e19e7757561176260c0fd1641081
https://pubmed.ncbi.nlm.nih.gov/21215621

Desulfonylation of Indoles and 7-Azaindoles Using Sodium tert-Butoxide

Autor: Charlotte Chaulet, Marie-Claude Viaud-Massuard, Joan Basset, Maria-Dolores Pujol, Cécile Croix

Publikováno v: SYNLETT
SYNLETT, Georg Thieme Verlag, 2010, pp.1481-1484

International audience; A mild method for the desulfonylation of N-indoles and N-azaindoles is described. Deprotection is carried out under basic conditions, using sodium tert-butoxide in dioxane. Several functionalized indoles and 7-azaindoles were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54e23b714ae867c27faec6d84a9f2c4
https://hal.science/hal-00614869