Výsledky vyhledávání - "Charlotte B. Nilsson"

Identification of end points relevant to detection of potentially adverse drug reactions

Autor: Lars Wärngård, Charlotte B. Nilsson, Ina Schuppe-Koistinen, Kerstin Kenne, Heike Hellmold

Publikováno v: Toxicology Letters. 127:239-243

Expectations are high that the use of proteomics, gene arrays and metabonomics will improve risk assessment and enable prediction of toxicity early in drug development. These molecular profiling techniques may be used to classify compounds and to ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b349770f0ee01a95a09221e330198e
https://doi.org/10.1016/s0378-4274(01)00505-7

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The Retinoid Signaling System — A Target in Dioxin Toxicity

Autor: Helen Håkansson, Charlotte B. Nilsson

Publikováno v: Critical Reviews in Toxicology. 32:211-232

This review summarizes the available data on the effects of dioxins on retinoid levels, retinoid-related enzyme activities, and toxicological endpoints that have been correlated to retinoid effects. Similarities between dioxin toxicity and retinoid d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fe1297d6d335b1863f45ea687d5146
https://doi.org/10.1080/20024091064228

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Mobilization of Vitamin A Stores in Rats after Administration of 2,3,7,8-Tetrachlorodibenzo-p-dioxin: A Kinetic Analysis

Autor: Joanne Balmer Green, Michael H. Green, Sean K. Kelley, Charlotte B. Nilsson, Helen Håkansson

Publikováno v: Toxicological Sciences. 55:478-484

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental contaminant that prevents the normal accumulation of vitamin A in liver and causes increased excretion of vitamin A. To determine what alterations in vitamin A metabolism occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628c457b201c5fd2a3d0a0fcce30a3bf
https://doi.org/10.1093/toxsci/55.2.478

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EFFECT OF 2,3,7,8-TETRACHLORODIBENZO- p -DIOXIN ON THE LYMPHATIC ABSORPTION OF A SINGLE ORAL DOSE OF [3H]RETINOL AND ON THE INTESTINAL RETINOL ESTERIFICATION IN THE RAT

Autor: Annika Hanberg, Charlotte B. Nilsson, Helen Håkansson, Christina Trossvik

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 55:331-344

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the turnover of vitamin A in the body and inhibits the normal hepatic accumulation of dietary vitamin A. Vitamin A is absorbed in the small intestine, where it is incorporated into chylomicrons as ret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0a39c7c359ea2f170f76689bb9b51e
https://doi.org/10.1080/009841098158386

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Use of Model-Based Compartmental Analysis to Study Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Vitamin A Kinetics in Rats

Autor: Sean K. Kelley, Charlotte B. Nilsson, Michael H. Green, Joanne Balrner Green, Helen Håkansson

Publikováno v: Toxicological Sciences. 44:1-13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59e2c3beb4d586285a595d2b454f6427
https://doi.org/10.1093/toxsci/44.1.1

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Proprioception in Classical Ballet Dancers

Autor: Johan Leanderson, Charlotte B. Nilsson, Anders Wykman, Ejnar Eriksson

Publikováno v: The American Journal of Sports Medicine. 24:370-374

We studied prospectively the influence of ankle sprains on proprioception as measured by recording the pos tural sway of classical ballet dancers. Excellent bal ance and coordination are important for classical ballet dancers, and postural stability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6d87e09e2180fa39f93d98a88279fb
https://doi.org/10.1177/036354659602400320

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Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy

γ-Secretase inhibition represents a major therapeutic strategy for lowering amyloid β (Aβ) peptide production in Alzheimer's disease (AD). Progress toward clinical use of γ-secretase inhibitors has, however, been hampered due to mechanism-based a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc3d61009b088efcf33644856c3a50a
https://europepmc.org/articles/PMC6621836/

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Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms

Autor: Charlotte B. Nilsson, Abraham Brouwer, Christina Trossvik, Norbert B. Ghyselinck, Pi Hoegberg, Heinz Nau, A. Gerlienke Schuur, Helen Håkansson, Carsten K. Schmidt, Nicholas Fletcher, Pierre Chambon

Publikováno v: Hoegberg, P, Schmidt, C K, Fletcher, N, Nilsson, C B, Trossvik, C, Gerlienke Schuur, A, Brouwer, A, Nau, H, Ghyselinck, N B, Chambon, P & Hakansson, H 2005, ' Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms ', Chemico-Biological Interactions, vol. 156, no. 1, pp. 25-39 . https://doi.org/10.1016/j.cbi.2005.06.006
Chemico-Biological Interactions, 156(1), 25-39. Elsevier Ireland Ltd
Chemico-Biological Interactions
Chemico-Biological Interactions, Elsevier, 2005, 156 (1), pp.25-39. ⟨10.1016/j.cbi.2005.06.006⟩

International audience; We have investigated the role of Vitamin A (retinoid) proteins in hepatic retinoid processing under normal conditions and during chemical stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a chemical known to interf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d48eedfa21db31a601fe8e8a22d1f60
https://research.vu.nl/en/publications/4b9f347e-36d0-4cda-825a-6827fdba17ba

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