Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Charlotte Kloft"'
Autor:
Francis Williams Ojara, Andrea Henrich, Nicolas Frances, Yomna M. Nassar, Wilhelm Huisinga, Niklas Hartung, Kimberly Geiger, Stefan Holdenrieder, Markus Joerger, Charlotte Kloft
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 11, Pp 1714-1725 (2023)
Abstract Paclitaxel/platinum chemotherapy, the backbone of standard first‐line treatment of advanced non‐small cell lung cancer (NSCLC), exhibits high interpatient variability in treatment response and high toxicity burden. Baseline blood biomark
Externí odkaz:
https://doaj.org/article/a66563bd6bf14dcaa78e5deef69f42e4
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011777 (2024)
In systems biology and pharmacology, large-scale kinetic models are used to study the dynamic response of a system to a specific input or stimulus. While in many applications, a deeper understanding of the input-response behaviour is highly desirable
Externí odkaz:
https://doaj.org/article/04555528c2e84b979110c8c4ef630ac7
Autor:
Robin Michelet, Linda B. S. Aulin, Jens M. Borghardt, Teresa Dalla Costa, Paolo Denti, Manuel Ibarra, Guangda Ma, Bernd Meibohm, Goonaseelan (Colin) Pillai, Stephan Schmidt, Stefanie Hennig, Charlotte Kloft
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 6, Pp 743-747 (2023)
Externí odkaz:
https://doaj.org/article/d47a9342018b4215a7fc58031d099e10
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 690-705 (2023)
Abstract To help understand the complex and therapeutically challenging inflammatory bowel diseases (IBDs), we developed a systems biology model of the intestinal immune system that is able to describe main aspects of IBD and different treatment moda
Externí odkaz:
https://doaj.org/article/0f9590fc35d748c28e3f2ce3f6a7b04d
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 4, Pp 432-443 (2023)
Abstract Quantitative systems pharmacology (QSP) models integrate comprehensive qualitative and quantitative knowledge about pharmacologically relevant processes. We previously proposed a first approach to leverage the knowledge in QSP models to deri
Externí odkaz:
https://doaj.org/article/3d25fbf05ad54d40bd575c869072b6cf
Autor:
Mareike Berlak, Elizabeth Tucker, Mathurin Dorel, Annika Winkler, Aleixandria McGearey, Elias Rodriguez-Fos, Barbara Martins da Costa, Karen Barker, Elicia Fyle, Elizabeth Calton, Selma Eising, Kim Ober, Deborah Hughes, Eleni Koutroumanidou, Paul Carter, Reda Stankunaite, Paula Proszek, Neha Jain, Carolina Rosswog, Heathcliff Dorado-Garcia, Jan Jasper Molenaar, Mike Hubank, Giuseppe Barone, John Anderson, Peter Lang, Hedwig Elisabeth Deubzer, Annette Künkele, Matthias Fischer, Angelika Eggert, Charlotte Kloft, Anton George Henssen, Michael Boettcher, Falk Hertwig, Nils Blüthgen, Louis Chesler, Johannes Hubertus Schulte
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Background Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients. Resistance mechanisms, however, can also confer new resistance-specific vulnera
Externí odkaz:
https://doaj.org/article/141d19867f1b4f5b98e903127aa48cab
Autor:
Christina Scharf, Ferdinand Weinelt, Ines Schroeder, Michael Paal, Michael Weigand, Michael Zoller, Michael Irlbeck, Charlotte Kloft, Josef Briegel, Uwe Liebchen
Publikováno v:
Annals of Intensive Care, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Background Hemadsorption of cytokines is used in critically ill patients with sepsis or septic shock. Concerns have been raised that the cytokine adsorber CytoSorb® unintentionally adsorbs vancomycin. This study aimed to quantify vancomycin
Externí odkaz:
https://doaj.org/article/9b5936fe34104c658ef6aa3318deb7eb
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 2, Pp 185-198 (2022)
Abstract Model‐informed precision dosing (MIPD) is a quantitative dosing framework that combines prior knowledge on the drug‐disease‐patient system with patient data from therapeutic drug/ biomarker monitoring (TDM) to support individualized do
Externí odkaz:
https://doaj.org/article/e104c0356fa34eb5bd47df96020dae8b
Autor:
Robin Michelet, Davide Bindellini, Johanna Melin, Uta Neumann, Oliver Blankenstein, Wilhelm Huisinga, Trevor N. Johnson, Martin J. Whitaker, Richard Ross, Charlotte Kloft
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Introduction: Hydrocortisone is the standard of care in cortisol replacement therapy for congenital adrenal hyperplasia patients. Challenges in mimicking cortisol circadian rhythm and dosing individualization can be overcome by the support of mathema
Externí odkaz:
https://doaj.org/article/d3d3a2bd751d4b2c8bcbf57951781edb
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 3, Pp 241-254 (2021)
Abstract Model‐informed precision dosing (MIPD) using therapeutic drug/biomarker monitoring offers the opportunity to significantly improve the efficacy and safety of drug therapies. Current strategies comprise model‐informed dosing tables or are
Externí odkaz:
https://doaj.org/article/7b70c81188454a71a5d4378d2f433a17