Life course analysis on income and incident AMI: a Danish register-based cohort study

Autor: Charlotte Hougaard, Rikke Lund, Henrik Brønnum-Hansen, Margit Kriegbaum, Ingelise Andersen

Publikováno v: Journal of Epidemiology and Community Health. 73:810-816

BackgroundSocial inequality in ischaemic heart disease has been related to socioeconomic position in childhood, early adulthood and late adulthood. However, the impact of relative level of accumulated income periods across adult life course and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2b58a85e8e633af3df6106dddf2961
https://doi.org/10.1136/jech-2018-212043

A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo

Autor: Morten Grunnet, Henry Liu, Lassina Badolo, Morten Laursen, Kristen Frederiksen, Dunguo Lu, Charles R. Yang, Niels Svenstrup, Kim Dekermendjian, François Crestey, Jesper F. Bastlund, Henrik Sindal Jensen, Peter Hjørringgaard Larsen, Charlotte Hougaard, Jinhui Yang

Publikováno v: European Journal of Neuroscience. 46:1887-1896

Nav 1.1 (SCN1A) channels primarily located in gamma-aminobutyric acid (GABA)ergic fast-spiking interneurons are pivotal for action potential generation and propagation in these neurons. Inappropriate function of fast-spiking interneurons, leading to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e38a29db94532d067ae3df485ae102
https://doi.org/10.1111/ejn.13626

Phosphodiesterase 1 bridges glutamate inputs with NO- and dopamine-induced cyclic nucleotide signals in the striatum

Autor: Oliver Griesbeck, Dahdjim Betolngar, Jan Kehler, Liliana R. V. Castro, Charlotte Hougaard, Pierre Vincent, Jun Yang, Élia Mota, Arne Fabritius, Claus Tornby Christoffersen, Jacob Nielsen

Publikováno v: Cerebral Cortex
Cerebral Cortex, 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩
Cerebral Cortex, Oxford University Press (OUP), 2019, Epub ahead of print. ⟨10.1093/cercor/bhz041⟩

The calcium-regulated phosphodiesterase 1 (PDE1) family is highly expressed in the brain, but its functional role in neurones is poorly understood. Using the selective PDE1 inhibitor Lu AF64196 and biosensors for cyclic nucleotides including a novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58574bad650f7c419ae1faba3dcbb1
https://hdl.handle.net/21.11116/0000-0006-E090-921.11116/0000-0006-E091-821.11116/0000-0005-BCFD-B

Quantification of the functional expression of the Ca2+-activated K+channel KCa3.1 on microglia from adult human neocortical tissue

Autor: Linda V. Blomster, Jessica Klein, Palle Christophersen, Dorte Strøbæk, Jens D. Mikkelsen, Lars H. Pinborg, Charlotte Hougaard

Publikováno v: Glia. 64:2065-2078

The KCa 3.1 channel (KCNN4) is an important modulator of microglia responses in rodents, but no information exists on functional expression on microglia from human adults. We isolated and cultured microglia (max 1% astrocytes, no neurons or oligodend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13e7878a041880d54d0c6aa905a51dd5
https://doi.org/10.1002/glia.23040

Antidepressant treatment among social workers, human service professionals, and non-human service professionals:A multi-cohort study in Finland, Sweden and Denmark

Autor: Kristina Alexanderson, Henrik Brønnum-Hansen, Ville Aalto, Naja Hulvej Rod, Charlotte Hougaard, Ellenor Mittendorfer-Rutz, A. Sónden, O. Rantonen, Alice Jessie Clark, Mika Kivimäki, Tuula Oksanen, Paula Salo

Publikováno v: Rantonen, O, Alexanderson, K, Clark Lyth, A J, Aalto, V, Sónden, A, Brønnum-Hansen, H, Hougaard, C Ø, Rod, N H, Mittendorfer-Rutz, E, Kivimäki, M, Oksanen, T & Salo, P 2019, ' Antidepressant treatment among social workers, human service professionals, and non-human service professionals : A multi-cohort study in Finland, Sweden and Denmark ', Journal of Affective Disorders, vol. 250, pp. 153-162 . https://doi.org/10.1016/j.jad.2019.03.037

BACKGROUND: Social workers have an elevated risk for mental disorders, but little is known about their antidepressant treatment.AIMS: To examine any and long-term antidepressant treatment among social workers in Finland, Sweden and Denmark.METHODS: W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be8b8d8340a6f5e68ed56a09de9322a
https://curis.ku.dk/portal/da/publications/antidepressant-treatment-among-social-workers-human-service-professionals-and-nonhuman-service-professionals(fad5d024-b2f4-4753-abbb-349dcd49bf28).html