Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Charlotte, Dahlem"'
Autor:
Shilpee Chanda, Konstantin Lepikhov, Charlotte Dahlem, Hanna S. Schymik, Jessica Hoppstädter, An-Kristin Geber, Konrad Wagner, Sonja M. Kessler, Martin Empting, Alexandra K. Kiemer
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 41 (2024)
Background: The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is an oncofetal protein that is overexpressed in several cancer entities. Employing IMP2 knockout colorectal cancer cells, we could show the important role of IMP2 in several hallmarks of ca
Externí odkaz:
https://doaj.org/article/89d6e122b66b49bd99ed274709c6606a
Autor:
Charlotte Dahlem, Shilpee Chanda, Jan Hemmer, Hanna S. Schymik, Michael Kohlstedt, Christoph Wittmann, Alexandra K. Kiemer
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Natural products have been shown to serve as promising starting points for novel anti-cancer drugs. In this study, the anti-cancer activities of the purple compound violacein, initially isolated from Chromobacterium violaceum, were investigated. To h
Externí odkaz:
https://doaj.org/article/e9761f6f239f474088ddfc997384fc7f
Autor:
Jessica Hoppstädter, Anna Dembek, Marcus Höring, Hanna S. Schymik, Charlotte Dahlem, Afnan Sultan, Natalie Wirth, Salma Al-Fityan, Britta Diesel, Gilles Gasparoni, Jörn Walter, Volkhard Helms, Hanno Huwer, Martin Simon, Gerhard Liebisch, Marcel H. Schulz, Alexandra K. Kiemer
Publikováno v:
EBioMedicine, Vol 72, Iss , Pp 103578- (2021)
Background: Based on reports on elevated cholesterol levels in cancer cells, strategies to lower cholesterol synthesis have been suggested as an antitumour strategy. However, cholesterol depletion has also been shown to induce tumour-promoting action
Externí odkaz:
https://doaj.org/article/3207fcd633e64b2fbbeaa98ad6fb11a7
Autor:
Maria Lopatniuk, Florian Riedel, Julia Wildfeuer, Marc Stierhof, Charlotte Dahlem, Alexandra K. Kiemer, Andriy Luzhetskyy
Publikováno v:
Metabolic Engineering. 78:48-60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7387275140613666acc7f5f97f8c3f0
https://doi.org/10.1016/j.ymben.2023.04.015
https://doi.org/10.1016/j.ymben.2023.04.015
Autor:
Yu Mi Park, Charlotte Dahlem, Markus R. Meyer, Alexandra K. Kiemer, Rolf Müller, Jennifer Herrmann
Publikováno v:
Molecules, Vol 27, Iss 4, p 1290 (2022)
Zebrafish (ZF; Danio rerio) larvae have become a popular in vivo model in drug metabolism studies. Here, we investigated the metabolism of methyl 2-[1-(4-fluorobutyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate (4F-MDMB-BINACA) in ZF larvae afte
Externí odkaz:
https://doaj.org/article/c77b64e7e4314ef69ee6c363cb245e8d
Autor:
Jessica Hoppstädter, Anna Dembek, Rebecca Linnenberger, Charlotte Dahlem, Ahmad Barghash, Claudia Fecher-Trost, Gregor Fuhrmann, Marcus Koch, Annette Kraegeloh, Hanno Huwer, Alexandra K. Kiemer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases, and endogenous GCs play a key role in immune regulation. Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a w
Externí odkaz:
https://doaj.org/article/3928e6c3fec6417993d4fa921e4c05ce
Autor:
Irina Voitsekhovskaia, Constanze Paulus, Charlotte Dahlem, Yuriy Rebets, Suvd Nadmid, Josef Zapp, Denis Axenov-Gribanov, Christian Rückert, Maxim Timofeyev, Jörn Kalinowski, Alexandra K. Kiemer, Andriy Luzhetskyy
Publikováno v:
Microorganisms, Vol 8, Iss 5, p 680 (2020)
Natural products produced by bacteria found in unusual and poorly studied ecosystems, such as Lake Baikal, represent a promising source of new valuable drug leads. Here we report the isolation of a new Streptomyces sp. strain IB201691-2A from the Lak
Externí odkaz:
https://doaj.org/article/ba28a5b281d14863bb02cdb0bb1d8d46
Autor:
Adriely Goes, Philipp Lapuhs, Thomas Kuhn, Eilien Schulz, Robert Richter, Fabian Panter, Charlotte Dahlem, Marcus Koch, Ronald Garcia, Alexandra K. Kiemer, Rolf Müller, Gregor Fuhrmann
Publikováno v:
Cells, Vol 9, Iss 1, p 194 (2020)
In 2019, it was estimated that 2.5 million people die from lower tract respiratory infections annually. One of the main causes of these infections is Staphylococcus aureus, a bacterium that can invade and survive within mammalian cells. S. aureus int
Externí odkaz:
https://doaj.org/article/3505b391888948319815d5c756c434cd
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb3971f49683337ed1fb9ebfa7767bc8
https://doi.org/10.1136/jitc-2022-sitc2022.1116
https://doi.org/10.1136/jitc-2022-sitc2022.1116
Autor:
Reem K. Fathalla, Wolfgang Fröhner, Chantal D. Bader, Patrick D. Fischer, Charlotte Dahlem, Deep Chatterjee, Sebastian Mathea, Alexandra K. Kiemer, Haribabu Arthanari, Rolf Müller, Mohammad Abdel-Halim, Christian Ducho, Matthias Engel
Publikováno v:
Journal of medicinal chemistry. 65(21)
To develop novel antibiotics, targeting the early steps of cell wall peptidoglycan biosynthesis seems to be a promising strategy that is still underutilized. MurA, the first enzyme in this pathway, is targeted by the clinically used irreversible inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7a4c1c8550c239299f00a092480032
https://pubmed.ncbi.nlm.nih.gov/36269107
https://pubmed.ncbi.nlm.nih.gov/36269107