A novel peanut allergy immunotherapy: Plant-based enveloped Ara h 2 Bioparticles activate dendritic cells and polarize T cell responses to Th1

Autor: Charlotte Castenmiller, MSc, Noémi Anna Nagy, MD, Pascal Zion Kroon, MSc, Lydia Auger, Réjean Desgagnés, MSc, Caroline Martel, MSc, Lucie Mirande, MSc, Bertrand Morel, PhD, Joannie Roberge, MSc, Virginie Stordeur, MSc, Guy Tropper, MD, FRCSC, Louis Philipe Vézina, PhD, Ronald van Ree, PhD, Véronique Gomord, PhD, Esther Christina de Jong, PhD

Publikováno v: World Allergy Organization Journal, Vol 16, Iss 11, Pp 100839- (2023)

Introduction: As the only market-authorized allergen immunotherapy (AIT) for peanut allergy is accompanied by a high risk of side effects and mainly induces robust desensitization without sustained efficacy, novel treatment options are required. Pean

Externí odkaz: https://doaj.org/article/c3fad01a171e4c52b03b29161048e6f2

Uptake Kinetics Of Liposomal Formulations of Differing Charge Influences Development of in Vivo Dendritic Cell Immunotherapy

Autor: Noémi Anna Nagy, Charlotte Castenmiller, Fernando Lozano Vigario, Rinske Sparrius, Toni M.M. van Capel, Aram M. de Haas, Yvette van Kooyk, Ronald van Ree, Sander W. Tas, Teunis B.H. Geijtenbeek, Wim Jiskoot, Bram Slütter, Esther C. de Jong

Publikováno v: Nagy, N A, Castenmiller, C, Vigario, F L, Sparrius, R, van Capel, T M M, de Haas, A M, van Kooyk, Y, van Ree, R, Tas, S W, Geijtenbeek, T B H, Jiskoot, W, Slütter, B & de Jong, E C 2022, ' Uptake Kinetics Of Liposomal Formulations of Differing Charge Influences Development of in Vivo Dendritic Cell Immunotherapy ', European Journal of Pharmaceutical Sciences, vol. 111, no. 4, pp. 1081-1091 . https://doi.org/10.1016/j.xphs.2022.01.022
European Journal of Pharmaceutical Sciences, 111(4), 1081-1091. Elsevier
Journal of pharmaceutical sciences, 111(4), 1081-1091. John Wiley and Sons Inc.
Journal of Pharmaceutical Sciences, 111(4), 1081-1091. ELSEVIER SCIENCE INC

Dendritic cells (DCs) control adaptive immunity and are therefore attractive for in vivo targeting to either induce immune activation or tolerance, depending on disease. Liposomes, nanoparticles comprised of a lipid bi-layer, provide a nanoplatform f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2430cd417d990b4dd9f955c9340dff4
https://doi.org/10.1016/j.xphs.2022.01.022

Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease

Autor: Meike U. Rohrbach, Francisco J. Arjona, Eric H. J. Verschuren, René J. M. Bindels, Juan Pablo Rigalli, Charlotte Castenmiller, Dorien J.M. Peters, Joost G. J. Hoenderop

Publikováno v: The Faseb Journal, 34, 5, pp. 6382-6398
The Faseb Journal, 34, 6382-6398
FASEB Journal, 34(5), 6382-6398. WILEY

Tubular ATP release is regulated by mechanosensation of fluid shear stress (FSS). Polycystin-1/polycystin-2 (PC1/PC2) functions as a mechanosensory complex in the kidney. Extracellular ATP is implicated in polycystic kidney disease (PKD), where PC1/P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7194eec63145dfd9155a9746e361f9
https://hdl.handle.net/2066/219079

Sensing of tubular flow and renal electrolyte transport

Autor: Eric H J, Verschuren, Charlotte, Castenmiller, Dorien J M, Peters, Francisco J, Arjona, René J M, Bindels, Joost G J, Hoenderop

Publikováno v: Nature reviews. Nephrology. 16(6)

The kidney is a remarkable organ that accomplishes the challenge of removing waste from the body and simultaneously regulating electrolyte and water balance. Pro-urine flows through the nephron in a highly dynamic manner and adjustment of the reabsor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c37af11400953fdaa10105742106aff
https://pubmed.ncbi.nlm.nih.gov/32127698