Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

Autor: Christina Gerstner, Anatoly Dubnovitsky, Charlotta Sandin, Genadiy Kozhukh, Hannes Uchtenhagen, Eddie A. James, Johan Rönnelid, Anders Jimmy Ytterberg, Jennifer Pieper, Evan Reed, Karolina Tandre, Mary Rieck, Roman A. Zubarev, Lars Rönnblom, Tatyana Sandalova, Jane H. Buckner, Adnane Achour, Vivianne Malmström

Publikováno v: Frontiers in Immunology, Vol 7 (2016)

Antibodies to citrullinated proteins, common in rheumatoid arthritis (RA) patients, are strongly associated to a specific set of HLA-DR alleles including HLA-DRB1*04:01, *04:04, and *01:01. Here, we first demonstrate that autoantibody levels toward t

Externí odkaz: https://doaj.org/article/0896a9add6fe43039b24b4c4429423b1

Functional dissection of Streptococcus pyogenes M5 protein: the hypervariable region is essential for virulence.

Autor: Johan Waldemarsson, Margaretha Stålhammar-Carlemalm, Charlotta Sandin, Francis J Castellino, Gunnar Lindahl

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7279 (2009)

The surface-localized M protein of Streptococcus pyogenes is a major virulence factor that inhibits phagocytosis, as determined ex vivo. Because little is known about the role of M protein in vivo we analyzed the contribution of different M protein r

Externí odkaz: https://doaj.org/article/d9f1ef4b10a945c0a3f79e9516940b1b

Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

Autor: Megan Tatum, Eddie A. James, Jennifer Pieper, Betty B. Yue, Jane H. Buckner, Lars Klareskog, John A. Gebe, Melissa Peda, Charlotta Sandin, Vivianne Malmström, Mary Rieck

Publikováno v: Arthritis & Rheumatology. 66:1712-1722

Rheumatoid arthritis (RA) is a chronic disease characterized by inflammation and destruction of joints and the surrounding tissue (1;2). This destruction is mediated through autoimmune processes as evidenced by the appearance of specific serologic ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d34d356bddd5aa975df90effbb9097c
https://doi.org/10.1002/art.38637

Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted alpha-Enolase T Cell Epitope in Rheumatoid Arthritis

Autor: Christina Gerstner, Anatoly Dubnovitsky, Charlotta Sandin, Genadiy Kozhukh, Hannes Uchtenhagen, Eddie A. James, Johan Rönnelid, Anders Jimmy Ytterberg, Jennifer Pieper, Evan Reed, Karolina Tandre, Mary Rieck, Roman A. Zubarev, Lars Rönnblom, Tatyana Sandalova, Jane H. Buckner, Adnane Achour, Vivianne Malmström

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 7 (2016)
'Frontiers in Immunology ', vol: 7, pages: 494-1-494-12 (2016)
Europe PubMed Central

Antibodies to citrullinated proteins, common in rheumatoid arthritis (RA) patients, are strongly associated to a specific set of HLA-DR alleles including HLA-DRB1*04:01, *04:04, and *01:01. Here, we first demonstrate that autoantibody levels toward t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850868ca74bbee01b7a9e264eeea5ed1
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310749

Signal sequence directs localized secretion of bacterial surface proteins

Autor: Eric Carlemalm, Margaretha Stålhammar-Carlemalm, Fredric Carlsson, Klas Flärdh, Charlotta Sandin, Gunnar Lindahl

Publikováno v: Nature. 442:943-946

All living cells require specific mechanisms that target proteins to the cell surface. In eukaryotes, the first part of this process involves recognition in the endoplasmic reticulum of amino-terminal signal sequences and translocation through Sec tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d09369ee1f52f24440b5e5ff27c835
https://doi.org/10.1038/nature05021