Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Charlotta Liljebris"'
Autor:
Hans Lennernäs, Charlotta Liljebris, Magnus Brisander, Gérald Jesson, Per Andersson, Gunnar Larfors, Leif Stenke
Publikováno v:
Blood. 140:9652-9653
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb901d01ee1d4620511bc30852ba3bd5
https://doi.org/10.1182/blood-2022-169884
https://doi.org/10.1182/blood-2022-169884
Autor:
Gunnar Larfors, Hans Lennernäs, Charlotta Liljebris, Magnus Brisander, Gérald Jesson, Per Andersson, Leif Stenke
Publikováno v:
Blood. 140:6769-6770
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07ccf3ab5110d53ad72fdb65056a5fd7
https://doi.org/10.1182/blood-2022-156487
https://doi.org/10.1182/blood-2022-156487
Autor:
Agneta Tjernberg, Eva Björkstrand, Bo Lundgren, Stephen James, Styrbjörn Byström, Charlotta Liljebris, Pawel Baranczewski, Malin Warolén
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:711-719
Growth factor and insulin signal transduction comprise series of protein kinases and protein phosphatases whose combined activities serve to propagate the growth factor signal in a regulated fashion. It was shown previously that such signaling cascad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2281d155e824c85f76c927d70b88d618
https://doi.org/10.1124/jpet.103.062745
https://doi.org/10.1124/jpet.103.062745
Autor:
Stephen James, Lars Tedenborg, Jessica Martinsson, Alf Nygren, James Duffy, Charlotta Liljebris, Emma Barker, Meredith Williams
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3197-3212
A series of novel pyridazine analogues were prepared and the structure–activity relationship of their behavior as inhibitors of PTP1B was evaluated. Most of the analogues had potencies in the low micromolar range. The in vitro kinetics of this comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660953db98b10343039422cc5e188e74
https://doi.org/10.1016/s0968-0896(02)00176-1
https://doi.org/10.1016/s0968-0896(02)00176-1
Autor:
Heinrich J. Schostarez, F. Craig Stevens, John E. Bleasdale, Theresa J. O’Sullivan, Scott D. Larsen, Charlotta Liljebris, Derek Ogg, Barbara J. Palazuk, Tjeerd Barf, Paul D. May
Publikováno v:
Journal of Medicinal Chemistry. 45:598-622
Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling in part by dephosphorylating key tyrosine residues within the regulatory domain of the beta-subunit of the insulin receptor (IR), thereby attenuating receptor tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cec9ff7a74c33d8e12ec80028a71a4
https://doi.org/10.1021/jm010393s
https://doi.org/10.1021/jm010393s
Publikováno v:
Molecular and Cellular Endocrinology. 173:109-120
One strategy to treat the insulin resistance that is central to type II diabetes mellitus may be to maintain insulin receptors (IR) in the active (tyrosine phosphorylated) form. Because protein tyrosine phosphatase 1B (PTP1B) binds and subsequently d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6439cbf549fe98b35aa0e454f75e32dc
https://doi.org/10.1016/s0303-7207(00)00402-0
https://doi.org/10.1016/s0303-7207(00)00402-0
Publikováno v:
Tetrahedron. 51:9139-9154
Palladium catalyzed intramolecular cyclizalions of the 15 R and 15 S epimers of 17-(2-iodophenyl)-18,19,20-trinorprostaglandin F 2α isopropylester [(15 R )- 5 and (15 S )- 5 , respectively] produce a complex mixture of products including various tet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d6c12d4aec32d1a8be7520f1999df1
https://doi.org/10.1016/0040-4020(95)00511-6
https://doi.org/10.1016/0040-4020(95)00511-6
Publikováno v:
Journal of Medicinal Chemistry. 38:289-304
The 15R and 15S epimers of a series of phenyl substituted analogs of 17-phenyl-18,19,20-trinorprostaglandin F2 alpha isopropyl ester [(15S)-3] have been synthesized. The intraocular pressure (IOP) lowering effects and potential side effects of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d864372a9dc3bf5868db33086ad87187
https://doi.org/10.1021/jm00002a011
https://doi.org/10.1021/jm00002a011
Palladium catalyzed syntheses of phenyl-substittuted pgf2α analogues: potential antigluaucoma agents
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:241-244
A PGF 2α -isopropylester derivative with a modified ω-chain containing a phenyl group ( 1 ) is an interesting antiglaucoma agent. Herein we described a synthetic strategy which provides an arrays of derivatives of 1 by use of palladium catalyzed me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7695fca46069dbc54b9b14e74b79e8e6
https://doi.org/10.1016/s0960-894x(01)80884-2
https://doi.org/10.1016/s0960-894x(01)80884-2
Publikováno v:
ChemInform. 27
Novel prostaglandin F2α derivatives, functionalized at C13 and C14, have been prepared. 17-Phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester [(15S)-1] and its epimer [(15R)-1] were stereoselectively epoxidized, using Sharpless conditions, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb4798b8e9d8bcec0c6baa186751f8f
https://doi.org/10.1002/chin.199641235
https://doi.org/10.1002/chin.199641235