Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Charlotta Grånäs"'
Autor:
Filippo Magaraci, Thomas Coulter, Jakob Felding, Serge G. Reignier, Christian Krog-Jensen, Christian A.G.N. Montalbetti, Muhammed Kamal Uddin, Charlotta Grånäs
Publikováno v:
Tetrahedron Letters. 47:5973-5975
We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9a6427504e13c03cfde16293c188d80
https://doi.org/10.1016/j.tetlet.2006.06.045
https://doi.org/10.1016/j.tetlet.2006.06.045
Autor:
Birgitte Bruun Rasmussen, Elisabeth D. Galsgaard, Louise Maymann Rasmussen, Charlotta Grånäs Folkesson, Martin W. Berchtold, Leif Christensen, Svetlana Panina
Publikováno v:
The Journal of endocrinology. 201(1)
The pituitary hormone PRL is involved in tumorigenesis in rodents and humans. PRL promotes proliferation, survival and migration of cancer cells acting via the PRL receptor (PRLR). Aiming to perform a large-scale immunohistochemical (IHC) screening o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76aca03912126b4783a4df39905f6202
https://pubmed.ncbi.nlm.nih.gov/19153125
https://pubmed.ncbi.nlm.nih.gov/19153125
Autor:
Thomas Stephen Coulter, Serge G. Reignier, Christian A.G.N. Montalbetti, Charlotta Grånäs, Steven Butcher, Christian Krog-Jensen, Muhammed Kamal Uddin, Jakob Felding
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(10)
Syntheses and structure-antiproliferative relationship for oxyphenisatin analogues are described. The cell proliferation data showed that the presence of substituents (especially F, Cl, Me, CF(3), and OMe) in the 6- and 7-position of oxyphenisatin ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441ea4b0cf7819e31986794c189daae3
https://pubmed.ncbi.nlm.nih.gov/17368900
https://pubmed.ncbi.nlm.nih.gov/17368900
Autor:
Charlotta Grånäs, Morten Praestegaard, Viggo Linde, Søren Jensby Nielsen, Frosty Loechel, Betina Kerstin Lundholt, Sara Petersen Bjørn, Eva-Maria Damsgaard Nielsen, Hans-Christian Pedersen, Christian Krogh-Jensen
Publikováno v:
Journal of biomolecular screening. 11(4)
The RAS-mitogen-activated protein kinase (MAPK) signaling pathway has a central role in regulating the proliferation and survival of both normal and tumor cells. This pathway has been 1 focus area for the development of anticancer drugs, resulting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa1121ccaa13e89e2dc6708eaad465
https://pubmed.ncbi.nlm.nih.gov/16751337
https://pubmed.ncbi.nlm.nih.gov/16751337
Publikováno v:
The Journal of biological chemistry. 279(5)
Recently we showed evidence that mutation of Tyr-335 to Ala (Y335A) in the human dopamine transporter (hDAT) alters the conformational equilibrium of the transport cycle. Here, by substituting, one at a time, 16 different bulky or charged intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c86f1a3d10577105621947981d32d5
https://pubmed.ncbi.nlm.nih.gov/14597628
https://pubmed.ncbi.nlm.nih.gov/14597628
Publikováno v:
The Journal of biological chemistry. 278(7)
The structural basis of phosphorylation and its putative role in internalization were investigated in the human dopamine transporter (hDAT). Activation of protein kinase C (PKC) was achieved either directly by treatment with 4-alpha-phorbol 12-myrist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d515fe9ff1fa0bacbe8984779e1a9921
https://pubmed.ncbi.nlm.nih.gov/12464618
https://pubmed.ncbi.nlm.nih.gov/12464618
Publikováno v:
European journal of pharmacology. 421(2)
The antagonist radioligand [ 3 H]GR125743 and the agonist radioligand [ 3 H]5-HT were used to investigate the pharmacological characteristics of the G protein uncoupled agonist low-affinity and G protein coupled agonist high-affinity conformations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84b593f006e33ccaec3e217faffe7a9
https://pubmed.ncbi.nlm.nih.gov/11399261
https://pubmed.ncbi.nlm.nih.gov/11399261
Autor:
Dan Larhammar, Charlotta Grånäs
Publikováno v:
European journal of pharmacology. 380(2-3)
Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e48b31bfefa9d9f13b23138db0f9e46
https://pubmed.ncbi.nlm.nih.gov/10513577
https://pubmed.ncbi.nlm.nih.gov/10513577
Publikováno v:
Journal of receptor and signal transduction research. 18(4-6)
We have used a combination of sequence comparisons, computer-based modeling and site-directed mutagenesis to investigate the molecular interactions involved in ligand binding and signal transduction of the human 5-HT1B receptor. Two amino acid residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8331bf7d618e687571306efd1b4b4cf8
https://pubmed.ncbi.nlm.nih.gov/9879059
https://pubmed.ncbi.nlm.nih.gov/9879059
Publikováno v:
European journal of pharmacology. 349(2-3)
Site-directed mutagenesis was used to investigate the molecular interactions involved in ligand binding to the human 5-HT1B receptor. Six mutants were constructed at four positions and expressed in Chinese hamster ovary cells. Substitution of the ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5edd951b4a100e626e7c26bab15f2a
https://pubmed.ncbi.nlm.nih.gov/9671119
https://pubmed.ncbi.nlm.nih.gov/9671119