Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Charlotta Fred"'
Publikováno v:
Journal of Chromatography B. 878:2497-2501
A molecularly imprinted polymer, MIP, was prepared and evaluated as SPE sorbent for a cyclicized adduct formed to N-terminal valine (Pyr-Val) in hemoglobin from 1,2:3,4-diepoxybutane (DEB). This metabolite plays an important role in the carcinogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64d6a6bcb926609866918664dfb21af
https://doi.org/10.1016/j.jchromb.2010.02.012
https://doi.org/10.1016/j.jchromb.2010.02.012
Publikováno v:
Cancer Research. 68:8014-8021
In cancer tests with 1,3-butadiene (BD), the mouse is much more sensitive than the rat. This is considered to be related to the metabolism of BD to the epoxide metabolites, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane, and 1,2-epoxy-3,4-butanediol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8d23b6d9be1b90c35204397be8edf9
https://doi.org/10.1158/0008-5472.can-08-0334
https://doi.org/10.1158/0008-5472.can-08-0334
Autor:
Ingrid Pontén, Michael R. O’Donovan, David J. Nicholls, Alan Young, Alaa Saad, Cecilia Diaz Pohl, Peter Mutch, Charlotta Fred, Per M. Åberg
Publikováno v:
Mutagenesis. 28(2)
AZD9708 is a new chemical entity with selective and longacting β2-agonistic properties currently being evaluated by AstraZeneca for potential use in treatment of respiratory diseases by the inhaled route. As part of the toxicological characterisatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc73a7a3e66127da52af2e193ac5f003
https://pubmed.ncbi.nlm.nih.gov/23408845
https://pubmed.ncbi.nlm.nih.gov/23408845
Autor:
James Harvey, Michelle O. Kenyon, Angela White, Sandy Weiner, Catrin Hasselgren, Jennifer B. Munzner, Krista L. Dobo, Robert A. Jolly, Robin Neft, Susanne Glowienke, Charlotta Fred, Nigel Greene, Wolfgang Muster, M. Vijayaraj Reddy
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 62(3)
With the increasing emphasis on identification and low level control of potentially genotoxic impurities (GTIs), there has been increased use of structure-based assessments including application of computerized models. To date many publications have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c266709a2ab25a4c0007518191a173
https://pubmed.ncbi.nlm.nih.gov/22321701
https://pubmed.ncbi.nlm.nih.gov/22321701
Autor:
Charlotta Fred, George Bolcsfoldi, Cecilia Diaz Pohl, Catherine C. Priestley, Michael R. O’Donovan
Publikováno v:
Mutation research. 723(2)
An improved protocol for the radiolabel DNA-binding assay, which gives a high yield of highly pure DNA has been developed by use of mouse lymphoma cells. The critical difference from previously published methods is the use of enzymatic degradation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e464b2023975361ebaab05bb4a01c4
https://pubmed.ncbi.nlm.nih.gov/21640194
https://pubmed.ncbi.nlm.nih.gov/21640194
Publikováno v:
Chemical research in toxicology. 22(9)
The reduced state of vitamin B(12), cob(I)alamin, acts as a supernucleophile that reacts ca. 10(5) times faster than standard nucleophiles, for example, thiols. Methods have been developed for trapping electrophilically reactive compounds by exploiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a136671e99919d6e04b4af596b36a3
https://pubmed.ncbi.nlm.nih.gov/19764821
https://pubmed.ncbi.nlm.nih.gov/19764821
Autor:
Margareta Törnqvist, Charlotta Fred, Alistair P. Henderson, Tatiana Cantillana, Bernard T. Golding
Publikováno v:
Rapid communications in mass spectrometry : RCM. 18(18)
Isoprene (2-methylbuta-1,3-diene) is a multi-site carcinogen in rodents. To evaluate the role of the diepoxide metabolite (1,2:3,4-diepoxy-2-methylbutane) in carcinogenesis, measurements of in vivo doses of the diepoxide are needed. The in vivo dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21567673196955976d8cecbe6ed0d168
https://pubmed.ncbi.nlm.nih.gov/15378724
https://pubmed.ncbi.nlm.nih.gov/15378724
Autor:
Johanna Minten, Per Rydberg, Margareta Törnqvist, Charlotta Fred, Thomas Alsberg, Johanna Haglund
Publikováno v:
Journal of separation science. 27(7-8)
Analytical methods facilitating studies of electrophilically reactive and genotoxic compounds in vitro and in vivo are needed. The strong nucleophile, cob(I)alamin, formed by reduction of Vitamin B12 [cob(III)alamin], may be used for trapping and ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2469d36361459982f77bb379ee149658
https://pubmed.ncbi.nlm.nih.gov/15335048
https://pubmed.ncbi.nlm.nih.gov/15335048
Publikováno v:
Chemical research in toxicology. 17(6)
For cancer risk assessment of 1,3-butadiene from rodent cancer test data, the in vivo doses of formed 1,2:3,4-diepoxybutane (DEB) should be known. In vivo doses of DEB were measured through a specific reaction product with hemoglobin (Hb), a ring-clo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ce92de57d6f2b73de38f1d6a9e7a8d
https://pubmed.ncbi.nlm.nih.gov/15206899
https://pubmed.ncbi.nlm.nih.gov/15206899
Publikováno v:
Mutation research. 585(1-2)
1,3-Butadiene and isoprene (2-methyl-1,3-butadiene) are chemically related substances that are carcinogenic to rodents. The overall aim of this work is to elucidate the role of the genotoxic action of diepoxide metabolites in the carcinogenesis of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d138c9423cd5698a4eff57abc298114b
https://pubmed.ncbi.nlm.nih.gov/15925539
https://pubmed.ncbi.nlm.nih.gov/15925539