Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Charlisa Whyms"'
Autor:
Sagar Sridhara, Jay Rai, Charlisa Whyms, Hemant Goswami, Huan He, Walter Woodside, Michael P. Terns, Hong Li
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
This study presents Cryo-EM structures of the Lactococcus lactis Type III-A CRISPR-Cas effector complex in three functional states, including bound forms with cognate and non-cognate target RNA. The results suggest changing protein dynamics during ef
Externí odkaz:
https://doaj.org/article/4b9b4f8dde8c45529486ef3987f03a7c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
CRISPR-Cas based virus detection assays can be both rapid and sensitive. Here the authors use a Type III-A CRISPR-Cas system to detect SARS-CoV-2.
Externí odkaz:
https://doaj.org/article/161706c84d344a00814531cbfef33077
Autor:
Sagar Sridhara, Hemant N. Goswami, Jay Rai, Charlisa Whyms, Walter Woodside, Michael P. Terns, Jonathan H. Dennis, Hong Li
Publikováno v:
Biophysical Journal. 121:477a-478a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5e1526f786726b1824f2ef4a2dc83e0
https://doi.org/10.1016/j.bpj.2021.11.376
https://doi.org/10.1016/j.bpj.2021.11.376
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Among the currently available virus detection assays, those based on the programmable CRISPR-Cas enzymes have the advantage of rapid reporting and high sensitivity without the requirement of thermocyclers. Type III-A CRISPR-Cas system is a multi-comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813f09d91b0ea949823d1cd84ae96dad
https://pubmed.ncbi.nlm.nih.gov/34580296
https://pubmed.ncbi.nlm.nih.gov/34580296
The small RNA-mediated immunity in bacteria depends on foreign RNA-activated and self RNA-inhibited enzymatic activities. The multi-subunit Type III-A CRISPR-Cas effector complex (Csm) exemplifies this principle, but its molecular basis for regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2457cf047a0e0b34e06c26f1baa0ab8
https://doi.org/10.1101/2021.01.27.428455
https://doi.org/10.1101/2021.01.27.428455
