Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Charline Peng"'
Autor:
Axel Knebel, Charline Peng, Brian Werneburg, Xiang Li, Scott Jakes, Kevin Barringer, Jun Li, Lian Wang, Nick A. Morrice
Publikováno v:
Journal of Biochemistry. 141:353-362
The Pim family of Ser/Thr kinases has been implicated in the process of lymphomagenesis and cell survival. Known substrates of Pim kinases are few and poorly characterized. In this study we set out to identify novel Pim-2 substrates using the Kinase
Autor:
Charline Peng, Wangfang Hou, Sharon H. Willis, Anthony V. Nicola, Huan Lou, Gary H. Cohen, Roselyn J. Eisenberg, Ann H. Rux
Publikováno v:
Journal of Virology. 72:7091-7098
Glycoprotein D (gD) of herpes simplex virus (HSV) is essential for virus entry and has four functional regions (I to IV) important for this process. We previously showed that a truncated form of a functional region IV variant, gD1(Δ290-299t), had an
Autor:
J C Whitbeck, Charline Peng, Patricia G. Spear, Ruliang Xu, M Ponce de Leon, John D. Lambris, Roselyn J. Eisenberg, Sharon H. Willis, Lynn A. Spruce, Athena M. Soulika, Tao Peng, William T. Moore, M S Warner, R I Montgomery, Gary H. Cohen, Anthony V. Nicola, Huan Lou
Publikováno v:
Journal of Virology. 71:6083-6093
Glycoprotein D (gD) is a structural component of the herpes simplex virus (HSV) envelope which is essential for virus entry into host cells. Chinese hamster ovary (CHO-K1) cells are one of the few cell types which are nonpermissive for the entry of m
Autor:
Gary H. Cohen, Charline Peng, Shan Ling Hung, Ioanna Kostavasili, Harvey M. Friedman, Roselyn J. Eisenberg, John D. Lambris
Publikováno v:
Virology. 203:299-312
Glycoprotein C (gC) of herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) binds the human complement fragment C3b, but the two proteins differ in their ability to bind C3b on infected cell surfaces. In addition, gC-1, but not gC-2, accelerates the
Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase
Autor:
Andre White, Bennett T. Farmer, Anthony Kronkaitis, Lian Wang, Eugene R. Hickey, Charline Peng, Joey Studts, Jun Li, Kevin Barringer, Sheenah Mische, Kevin Chungeng Qian
Publikováno v:
The Journal of biological chemistry. 280(7)
Pim-1 kinase is a member of a distinct class of serine/threonine kinases consisting of Pim-1, Pim-2, and Pim-3. Pim kinases are highly homologous to one another and share a unique consensus hinge region sequence, ER-PXPX, with its two proline residue
Autor:
Ian Potocki, Shirlynn Chen, Rosemarie Sellati, Patricia L. Reilly, Kei Kishimoto, Emeigh Jonathan Emilian, Gerald Nabozny, Robert Rothlein, Donghong A. Gao, Miao Clara K, Daniel R. Goldberg, Sorcek Ronald J, Daniel Kuzmich, Terence A. Kelly, Drané O'Brien, Deborah D. Jeanfavre, Charline Peng, and Stephen H. Norris, Kevin Chungeng Qian, Elizabeth Mainolfi, Wu Jiang-Ping, Joseph R. Woska, Jocelyn A. Gunn
Publikováno v:
Journal of medicinal chemistry. 47(22)
A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochemical and metabolic properties of BIRT377 (1, Figure 1), a previously reported hydantoin-based LFA-1 inh
Autor:
Kevin Barringer, Roger R. LaFrance, Kevin Chungeng Qian, Sheenah Mische, Bennett T. Farmer, Alistair Baptiste, Joey Studts, Lian Wang, Charline Peng, Anthony Kronkaitis
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 1)
Pim kinases, including Pim-1, Pim-2 and Pim-3, belong to a distinctive serine/threonine protein-kinase family. They are involved in cytokine-induced signal transduction and the development of lymphoid malignancies. Their kinase domains are highly hom
Autor:
Charline Peng, Roselyn J. Eisenberg, Anthony V. Nicola, Ann H. Rux, Manuel Ponce de Leon, Gary H. Cohen, Sharon H. Willis
Herpes simplex virus (HSV) remains a major human pathogen worldwide (25 causing cold sores, eye and genital infections, blindness, encephalitis, and neonatal infections. Most adults have antibodies against the oral form of the virus HSV-1 (9), and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f07a13b96f6cffd3a0ba4d385598d468
https://doi.org/10.1385/0-89603-347-3:131
https://doi.org/10.1385/0-89603-347-3:131
Autor:
Sharon H. Willis, Anthony V. Nicola, J. Charles Whitbeck, Roselyn J. Eisenberg, Charline Peng, Ann H. Rux, Gary H. Cohen, Wangfang Hou, Lisa Salvador, Huan Lou
Previously, we showed that truncated soluble forms of herpes simplex virus (HSV) glycoprotein D (gDt) bound directly to a truncated soluble form of the herpesvirus entry mediator (HveAt, formerly HVEMt), a cellular receptor for HSV. The purpose of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582e5229e8b6e39b690f4406f60521b0
https://europepmc.org/articles/PMC110398/
https://europepmc.org/articles/PMC110398/
Publikováno v:
Journal of virology. 71(4)
Soluble forms of herpes simplex virus (HSV) glycoprotein D (gD) block viral penetration. Likewise, most HSV strains are sensitive to gD-mediated interference by cells expressing gD. The mechanism of both forms of gD-mediated inhibition is thought to