Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Charlie Laffeber"'
Autor:
Arnold Kuzniar, Charlie Laffeber, Berina Eppink, Karel Bezstarosti, Dick Dekkers, Henri Woelders, A Peter M Zwamborn, Jeroen Demmers, Joyce H G Lebbink, Roland Kanaar
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170762 (2017)
The potential effects of non-ionizing electromagnetic fields (EMFs), such as those emitted by power-lines (in extremely low frequency range), mobile cellular systems and wireless networking devices (in radio frequency range) on human health have been
Externí odkaz:
https://doaj.org/article/e456a0d28a134422a0d97699c342f767
Autor:
Fabian M.P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A.S.H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H.G. Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I. De Zeeuw, Aleksandra Badura, Meinrad Busslinger
Publikováno v:
Journal of Experimental Medicine. 220
Autor:
Fabian M.P. Kaiser, Sarah Gruenbacher, Maria Roa Oyaga, Enzo Nio, Markus Jaritz, Qiong Sun, Wietske van der Zwaag, Emanuel Kreidl, Lydia M. Zopf, Virgil A.S.H. Dalm, Johan Pel, Carolin Gaiser, Rick van der Vliet, Lucas Wahl, André Rietman, Louisa Hill, Ines Leca, Gertjan Driessen, Charlie Laffeber, Alice Brooks, Peter D. Katsikis, Joyce H.G. Lebbink, Kikuë Tachibana, Mirjam van der Burg, Chris I. De Zeeuw, Aleksandra Badura, Meinrad Busslinger
Publikováno v:
Journal of Experimental Medicine, 219(9). ROCKEFELLER UNIV PRESS
Journal of Experimental Medicine, 219(9). Rockefeller University Press
Journal of Experimental Medicine, 219(9):e20220498. Rockefeller University Press
Journal of Experimental Medicine, 219(9). Rockefeller University Press
Journal of Experimental Medicine, 219(9):e20220498. Rockefeller University Press
The genetic causes of primary antibody deficiencies and autism spectrum disorder (ASD) are largely unknown. Here, we report a patient with hypogammaglobulinemia and ASD who carries biallelic mutations in the transcription factor PAX5. A patient-speci
Autor:
Wen Y. Wu, Prarthana Mohanraju, Chunyu Liao, Belén Adiego-Pérez, Sjoerd C.A. Creutzburg, Kira S. Makarova, Karlijn Keessen, Timon A. Lindeboom, Tahseen S. Khan, Stijn Prinsen, Rob Joosten, Winston X. Yan, Anzhela Migur, Charlie Laffeber, David A. Scott, Joyce H.G. Lebbink, Eugene V. Koonin, Chase L. Beisel, John van der Oost
Publikováno v:
Molecular Cell, 82(23), 4487-4502.e7. Cell Press
Molecular Cell 82 (2022) 23
Molecular Cell, 82(23), 4487-4502.e7
Molecular Cell 82 (2022) 23
Molecular Cell, 82(23), 4487-4502.e7
CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA targets. Here, we describe the experimental characterization of a bacterial CRISPR effector protein C
Autor:
Peter Friedhoff, Olha Storozhuk, Joyce H.G. Lebbink, Mark S. Dillingham, Vladislav Kunetsky, Charlie Laffeber, Gwendolyn M Brouwer
We developed a sensitive, homogeneous fluorescence assay for the detection of DNA mismatches and DNA damage based on the mismatch repair (MMR) protein MutS. The assay is based on Förster resonance energy transfer (FRET) between SYBR Green I (SG), no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88abe25f23d0eceff5fe2219668478d1
https://doi.org/10.1101/2021.07.23.453479
https://doi.org/10.1101/2021.07.23.453479
Publikováno v:
Journal of Molecular Biology, 433(15):167058. Academic Press
Journal of Molecular Biology
Journal of Molecular Biology
Graphical abstract
Rapidly spreading new variants of SARS-CoV-2 carry multiple mutations in the viral spike protein which attaches to the angiotensin converting enzyme 2 (ACE2) receptor on host cells. Among these mutations are amino acid changes
Rapidly spreading new variants of SARS-CoV-2 carry multiple mutations in the viral spike protein which attaches to the angiotensin converting enzyme 2 (ACE2) receptor on host cells. Among these mutations are amino acid changes
Autor:
Doreth Bhairosing-Kok, Titia K. Sixma, Meindert H Lamers, Joyce H.G. Lebbink, Charlie Laffeber, Rafael Fernandez-Leiro, Alexander Fish, Flora S. Groothuizen, Herrie H.K. Winterwerp, Peter Friedhoff, Vladislav Kunetsky
Publikováno v:
Nature Structural and Molecular Biology, 28(4), 373-+. NATURE RESEARCH
Nature Structural and Molecular Biology, 28(4), 373-381. Nature Publishing Group
Nature Structural and Molecular Biology, 28(4), 373-381. Nature Publishing Group
DNA mismatch repair detects and removes mismatches from DNA by a conserved mechanism, reducing the error rate of DNA replication by 100- to 1,000-fold. In this process, MutS homologs scan DNA, recognize mismatches and initiate repair. How the MutS ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f31ea137fd48461aacd54316a9611fa
http://hdl.handle.net/1887/3276271
http://hdl.handle.net/1887/3276271
Autor:
Rafael, Fernandez-Leiro, Doreth, Bhairosing-Kok, Vladislav, Kunetsky, Charlie, Laffeber, Herrie H, Winterwerp, Flora, Groothuizen, Alexander, Fish, Joyce H G, Lebbink, Peter, Friedhoff, Titia K, Sixma, Meindert H, Lamers
Publikováno v:
Nature structuralmolecular biology. 28(4)
DNA mismatch repair detects and removes mismatches from DNA by a conserved mechanism, reducing the error rate of DNA replication by 100- to 1,000-fold. In this process, MutS homologs scan DNA, recognize mismatches and initiate repair. How the MutS ho
Autor:
Deborah Horst-Kreft, Joyce H.G. Lebbink, Wiggert A. van Cappellen, Dior M. J. M. Beerens, Youri Hoogstrate, Johan W. Mouton, Gert-Jan Kremers, Rob Joosten, John van der Oost, Charlie Laffeber, Duncan J. H. Gaskin, Gaurav Dugar, Rogier Louwen, Jeroen Demmers, Serena T. Bruens, Andrew P. Stubbs, Chinmoy Saha, Maarten Klunder, Peter J. van der Spek, Dik C. van Gent, Prarthana Mohanraju, Peter van Baarlen
Publikováno v:
Science Advances 6 (2020) 25
Science advances, 6(25):eaaz4849. American Association for the Advancement of Science
Science Advances, 6(25)
Science advances, 6(25):eaaz4849. American Association for the Advancement of Science
Science Advances, 6(25)
CRISPR-Cas9 systems are enriched in human pathogenic bacteria and have been linked to cytotoxicity by an unknown mechanism. Here, we show that upon infection of human cells, Campylobacter jejuni secretes its Cas9 (CjeCas9) nuclease into their cytopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac06800930fed35bc446b835458c41d
https://research.wur.nl/en/publications/guide-free-cas9-from-pathogenic-campylobacter-jejuni-bacteria-cau
https://research.wur.nl/en/publications/guide-free-cas9-from-pathogenic-campylobacter-jejuni-bacteria-cau
Autor:
Charlie Laffeber, Wiggert A. van Cappellen, Roland Kanaar, Martine Franckena, Hanny Odijk, Gerard C. van Rhoon, Nathalie van den Tempel
Publikováno v:
Oncotarget
Oncotarget, 8(27), 44593-44604. Impact Journals LLC
Oncotarget, 8(27), 44593-44604. Impact Journals LLC
Hyperthermia has a number of biological effects that sensitize tumors to radiotherapy in the range between 40-44 °C. One of these effects is heat-induced degradation of BRCA2 that in turn causes reduced RAD51 focus formation, which results in an att