Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer

Autor: Charlie Hatcher, George Richenberg, Samuel Waterson, Long H. Nguyen, Amit D. Joshi, Robert Carreras-Torres, Victor Moreno, Andrew T. Chan, Marc Gunter, Yi Lin, Conghui Qu, Mingyang Song, Graham Casey, Jane C. Figueiredo, Stephen B. Gruber, Jochen Hampe, Heather Hampel, Mark A. Jenkins, Temitope O. Keku, Ulrike Peters, Catherine M. Tangen, Anna H. Wu, David A. Hughes, Malte C. Rühlemann, Jeroen Raes, Nicholas J. Timpson, Kaitlin H. Wade

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract The role of the human gut microbiome in colorectal cancer (CRC) is unclear as most studies on the topic are unable to discern correlation from causation. We apply two-sample Mendelian randomization (MR) to estimate the causal relationship be

Externí odkaz: https://doaj.org/article/3de8785a834d4867853ad4bb6d8b5078

Systematic review and meta-analyses: What has the application of Mendelian randomization told us about the causal effect of adiposity on health outcomes? [version 2; peer review: 1 approved, 2 approved with reservations]

Autor: Kaitlin H Wade, Si Fang, Nicholas J Timpson, Laura J Corbin, Nancy McBride, Thomas Battram, Matthew A Lee, Charlie Hatcher, Wenxin Wan, Luke A McGuinness

Publikováno v: Wellcome Open Research, Vol 7 (2023)

Mendelian randomization (MR) is increasingly used for generating estimates of the causal impact of exposures on outcomes. Evidence suggests a causal role of excess adipose tissue (adiposity) on many health outcomes. However, this body of work has not

Externí odkaz: https://doaj.org/article/00574839a43c4f4087f8c36434469457

The EWAS Catalog: a database of epigenome-wide association studies [version 1; peer review: 2 approved]

Autor: Ryan Langdon, Matthew Suderman, Oliver Whitehurst, Hannah R. Elliott, Luke Mahoney, Matthew A. Lee, Caroline L. Relton, Giulia Mancano, Abigail C. Lay, Sarah H. Watkins, James R. Staley, Gibran Hemani, Thomas Battram, Gemma Crawford, Paul Yousefi, Mahsa Sheikhali Babaei, Tom R. Gaunt, Claire Prince, Charlie Hatcher, Gemma Sharp, Sahar Khodabakhsh, María Jesús Vega-Salas

Publikováno v: Wellcome Open Research, Vol 7 (2022)

Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, the increase in availability of DNA methylation me

Externí odkaz: https://doaj.org/article/65765757317b41d0b21facf330ef8c4e

Systematic review and meta-analyses:What has the application of Mendelian randomization told us about the causal effect of adiposity on health outcomes?

Autor: Matthew A Lee, Charlie Hatcher, Luke A McGuinness, Nancy McBride, Thomas Battram, Wenxin Wan, Si Fang, Kaitlin H Wade, Laura J Corbin, Nicholas J Timpson

Publikováno v: Lee, M, Hatcher, C A, McGuinness, L, Mcbride, N S, Battram, T M, Wan, W, Fang, S, Wade, K H, Corbin, L J & Timpson, N J 2022, ' Systematic review and meta-analyses : What has the application of Mendelian randomization told us about the causal effect of adiposity on health outcomes? ', Wellcome Open Research, vol. 7, no. 308 . https://doi.org/10.12688/wellcomeopenres.18657.1

Mendelian randomization (MR) is increasingly used for generating estimates of the causal impact of exposures on outcomes. Evidence suggests a causal role of excess adipose tissue (adiposity) on many health outcomes. However, this body of work has not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c56f91827c946bab7323a74975db48
https://research-information.bris.ac.uk/en/publications/2ea7a686-d396-484e-88b4-a3d47e13f0ed

The EWAS Catalog: a database of epigenome-wide association studies

Autor: Thomas Battram, Paul Yousefi, Gemma Crawford, Claire Prince, Mahsa Sheikhali Babaei, Gemma Sharp, Charlie Hatcher, María Jesús Vega-Salas, Sahar Khodabakhsh, Oliver Whitehurst, Ryan Langdon, Luke Mahoney, Hannah R. Elliott, Giulia Mancano, Matthew A. Lee, Sarah H. Watkins, Abigail C. Lay, Gibran Hemani, Tom R. Gaunt, Caroline L. Relton, James R. Staley, Matthew Suderman

Publikováno v: Battram, T, Yousefi, P, Crawford, G, Prince, C, Babaei, M S, Sharp, G, Hatcher, C, Vega-Salas, M J, Khodabakhsh, S, Whitehurst, O, Langdon, R, Mahoney, L, Elliott, H R (ed.), Mancano, G, Lee, M A, Watkins, S H, Lay, A C (ed.), Hemani, G, Gaunt, T R (ed.), Relton, C L (ed.), Staley, J R (ed.) & Suderman, M 2022, ' The EWAS Catalog: a database of epigenome-wide association studies ', Wellcome open research, vol. 7, pp. 41 . https://doi.org/10.12688/wellcomeopenres.17598.1
Battram, T, Yousefi, P, Crawford, G, Prince, C, Sheikhali Babaei, M, Sharp, G, Hatcher, C, Vega-Salas, M J, Khodabakhsh, S, Whitehurst, O, Langdon, R, Mahoney, L, Elliott, H R, Mancano, G, Lee, M A, Watkins, S H, Lay, A C, Hemani, G, Gaunt, T R, Relton, C L, Staley, J R & Suderman, M 2022, ' The EWAS Catalog : a database of epigenome-wide association studies ', Wellcome Open Research, vol. 7, pp. 41 . https://doi.org/10.12688/wellcomeopenres.17598.2

Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures and DNA methylation measured at thousands or millions of CpG sites across the genome. In recent years, the increase in availability of DNA methylation me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a71a484066c4205b363b9f582a0aa9
https://doi.org/10.31219/osf.io/837wn