Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Charlie Fehl"'
Autor:
Alexandra Fox, Garry D. Leonard, Nicholas Adzibolosu, Terrence Wong, Roslyn Tedja, Sapna Sharma, Radhika Gogoi, Robert Morris, Gil Mor, Charlie Fehl, Ayesha B. Alvero
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionOvarian and other peritoneal cancers have a strong tendency to metastasize into the surrounding adipose tissue. This study describes an effect of the adipose microenvironment on upregulation of sialic acid-containing glycans in ovarian ca
Externí odkaz:
https://doaj.org/article/b6293baa7f6a4f41a6c01d08bcd25f20
Autor:
Saheed A. Ayodeji, Bin Bao, Emily A. Teslow, Lisa A. Polin, Greg Dyson, Aliccia Bollig-Fischer, Charlie Fehl
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Enhanced glucose metabolism is a feature of most tumors, but downstream functional effects of aberrant glucose flux are difficult to mechanistically determine. Metabolic diseases including obesity and diabetes have a hyperglycemia
Externí odkaz:
https://doaj.org/article/544cf2f65d474bdbaf1e18dafcbe805d
Publikováno v:
ACS Chem Biol
A fundamental mechanism that all eukaryotic cells use to adapt to their environment is dynamic protein modification with monosaccharide sugars. In humans, O-linked N-acetylglucosamine (O-GlcNAc) is rapidly added to and removed from diverse protein si
Publikováno v:
Bioorg Med Chem
Sugar additions to biomolecules, or glycans, are some of the most abundant biomolecule modifications in biology because they enable cells to adapt to changing nutrient and stress conditions. An unmet challenge for the field of glycobiology is the stu
Publikováno v:
ChemBioChem. 22:1854-1870
All human cells use O-GlcNAc protein modifications (O-linked N-acetylglucosamine) to rapidly adapt to changing nutrient and stress conditions through signaling, epigenetic, and proteostasis mechanisms. A key challenge for biologists in defining preci
Autor:
Saheed Ayodeji, Bin Bao, Emily A. Teslow, Lisa A. Polin, Greg Dyson, Aliccia Bollig-Fischer, Charlie Fehl
Enhanced glucose metabolism is a feature of almost all cancers, but downstream functional effects of aberrant glucose flux are difficult to mechanistically determine. The objective of this study is to characterize a mechanism by which elevated glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::446a87eb9076f995ffc644549b19d9e7
https://doi.org/10.1101/2022.03.14.484003
https://doi.org/10.1101/2022.03.14.484003
Autor:
Charlie Fehl, John A. Hanover
Publikováno v:
Nat Chem Biol
The vast array of cell types of multicellular organisms must individually fine-tune their internal metabolism. One important metabolic and stress regulatory mechanism is the dynamic attachment/removal of glucose-derived sugar N-acetylglucosamine on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d5dd5c8c0fc93a147804d2f09db820
https://europepmc.org/articles/PMC8712397/
https://europepmc.org/articles/PMC8712397/
Autor:
Charlie Fehl, Gideon J. Davies, Benjamin G. Davis, Karen Lees, Stephen J. Roberts, Wendy A. Offen, Dianna J. Bowles, Min Yang, Matthew G. Davidson, Eng-Kiat Lim
Publikováno v:
Nature Chemical Biology. 14(12)
The elucidation and prediction of how changes in a protein result in altered activities and selectivities remain a major challenge in chemistry. Two hurdles have prevented accurate family-wide models: obtaining (i) diverse datasets and (ii) suitable
Inhibition of androgen biosynthesis is clinically effective for treating androgen-responsive prostate cancer. Abiraterone is a clinical first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1) required for androgen biosynthesis. However, abirateron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5185ce8d72ac3337bd3b7e527864abca
Publikováno v:
Tetrahedron Letters. 56:3137-3140
The intramolecular Schmidt reaction of ketones and tethered azides is an efficient method for the generation of amides and lactams. This reaction is catalyzed by Lewis acids, which tightly bind the strongly basic amide product and result in product i