Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Charlie, Gourley"'
Autor:
Sarah J. Taylor, Robert L. Hollis, Charlie Gourley, C. Simon Herrington, Simon P. Langdon, Mark J. Arends
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDNA damage repair is frequently dysregulated in high grade serous ovarian cancer (HGSOC), which can lead to changes in chemosensitivity and other phenotypic differences in tumours. RFWD3, a key component of multiple DNA repair and maintenan
Externí odkaz:
https://doaj.org/article/0f37cae0814847a1b8d645d8c736be1e
Autor:
Robert L. Hollis, John P. Thomson, Juliette van Baal, Narthana Ilenkovan, Michael Churchman, Koen van de Vijver, Frederike Dijk, Alison M. Meynert, Clare Bartos, Tzyvia Rye, Ian Croy, Patricia Diana, Mignon van Gent, Helen Creedon, Rachel Nirsimloo, Christianne Lok, Charlie Gourley, C. Simon Herrington
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Low grade serous ovarian carcinoma (LGSOC) demonstrates unique clinical and molecular features compared to other ovarian cancer types. The relationship between common histological features of LGSOC and molecular events, such as hormone recep
Externí odkaz:
https://doaj.org/article/8acb6378ec15437ba487763df432313d
Autor:
Ricardo Roque, Ilda Patrícia Ribeiro, Margarida Figueiredo-Dias, Charlie Gourley, Isabel Marques Carreira
Publikováno v:
Biology, Vol 13, Iss 2, p 88 (2024)
Circulating tumour DNA (ctDNA) facilitates longitudinal study of the tumour genome, which, unlike tumour tissue biopsies, globally reflects intratumor and intermetastatis heterogeneity. Despite its costs, next-generation sequencing (NGS) has revoluti
Externí odkaz:
https://doaj.org/article/62f7f00011914b5f831c4c302aa6a36b
Autor:
Dominique Barnes, Nissreen Mohammad, Lien Hoang, Michael Anglesio, Robert L. Hollis, Charlie Gourley, Heather C. Stuart, Mark S. Carey, Gavin C.E. Stuart
Publikováno v:
Gynecologic Oncology Reports, Vol 44, Iss , Pp 101076- (2022)
It is well recognized that some patients with endometrioid gynecological cancers have tumors arising in multiple sites (ovary, endometrium, and endometriosis) at the time of diagnosis. Molecular analysis has helped discern whether these multisite can
Externí odkaz:
https://doaj.org/article/f3180e30608a44cebad77f09df6b9207
Autor:
Robert L. Hollis, Barbara Stanley, John P. Thomson, Michael Churchman, Ian Croy, Tzyvia Rye, Clare Bartos, Fiona Nussey, Melanie Mackean, Alison M. Meynert, Colin A. Semple, Charlie Gourley, C. Simon Herrington
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-9 (2021)
Abstract Endometrioid ovarian carcinoma (EnOC) is an under-investigated ovarian cancer type. Recent studies have described disease subtypes defined by genomics and hormone receptor expression patterns; here, we determine the relationship between thes
Externí odkaz:
https://doaj.org/article/4527ed8d1b464da188a3bb4b385ac1a6
Autor:
Jeffrey C.H. Goh, Charlie Gourley, David S P Tan, Angélica Nogueira-Rodrigues, Hesham Elghazaly, Marc Edy Pierre, Gonzalo Giornelli, Byoung-Gie Kim, Flavia Morales–Vasquez, Alexandra Tyulyandina
Publikováno v:
Gynecologic Oncology Reports, Vol 42, Iss , Pp 101028- (2022)
The incidence and mortality rates of ovarian cancer are increasing globally. Ovarian cancer is diagnosed at an advanced stage in 80% of women. After standard, platinum-based, front-line chemotherapy, poly (ADP-ribose) polymerase (PARP) inhibitors and
Externí odkaz:
https://doaj.org/article/d8b61cfeb7db4d489058ed2b8eecf815
Autor:
Robert L. Hollis, John P. Thomson, Barbara Stanley, Michael Churchman, Alison M. Meynert, Tzyvia Rye, Clare Bartos, Yasushi Iida, Ian Croy, Melanie Mackean, Fiona Nussey, Aikou Okamoto, Colin A. Semple, Charlie Gourley, C. Simon Herrington
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The molecular classification of endometroid ovarian carcinomas (EnOC) has not been established, preventing the development of stratified therapeutic approaches. Here the authors characterise the molecular landscape of EnOC by whole exome sequencing,
Externí odkaz:
https://doaj.org/article/232b42338ac04ca39f011da44d0890a8
Autor:
Dane Cheasley, Matthew J. Wakefield, Georgina L. Ryland, Prue E. Allan, Kathryn Alsop, Kaushalya C. Amarasinghe, Sumitra Ananda, Michael S. Anglesio, George Au-Yeung, Maret Böhm, David D. L. Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, Clare G. Fedele, Sian Fereday, Stephen B. Fox, C Blake Gilks, Charlie Gourley, Neville F. Hacker, Alison M. Hadley, Joy Hendley, Gwo-Yaw Ho, Siobhan Hughes, David G. Hunstman, Sally M. Hunter, Tom W. Jobling, Kimberly R. Kalli, Scott H. Kaufmann, Catherine J. Kennedy, Martin Köbel, Cecile Le Page, Jason Li, Richard Lupat, Orla M. McNally, Jessica N. McAlpine, Anne-Marie Mes-Masson, Linda Mileshkin, Diane M. Provencher, Jan Pyman, Kurosh Rahimi, Simone M. Rowley, Carolina Salazar, Goli Samimi, Hugo Saunders, Timothy Semple, Ragwha Sharma, Alice J. Sharpe, Andrew N. Stephens, Niko Thio, Michelle C. Torres, Nadia Traficante, Zhongyue Xing, Magnus Zethoven, Yoland C. Antill, Clare L. Scott, Ian G. Campbell, Kylie L. Gorringe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Whether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.
Externí odkaz:
https://doaj.org/article/9047c1d475514bf5becaaddcde7c44d4
Autor:
Citadel J. Cabasag, Melina Arnold, Mark Rutherford, Jacques Ferlay, Aude Bardot, Eileen Morgan, John Butler, Dianne L. O'Connell, Gregg Nelson, Claus Høgdall, Tine Schnack, Anna Gavin, Mark Elwood, Louise Hanna, Charlie Gourley, Prithwish De, Nathalie Saint‐Jacques, Lina Steinrud Mørch, Ryan R Woods, Alon D. Altman, Peter Sykes, Paul A. Cohen, Orla McNally, Bjørn Møller, Paul Walsh, David S. Morrison, Freddie Bray, Isabelle Soerjomataram
Publikováno v:
International Journal of Cancer. 152:1763-1777
The aim of the study is to provide a comprehensive assessment of incidence and survival trends of epithelial ovarian cancer (EOC) by histological subtype across seven high income countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446baed0a3ed030cce8537eac944cea4
https://doi.org/10.1002/ijc.34403
https://doi.org/10.1002/ijc.34403
Autor:
Chrysi Xintaropoulou, Carol Ward, Alan Wise, Suzanna Queckborner, Arran Turnbull, Caroline O. Michie, Alistair R. W. Williams, Tzyvia Rye, Charlie Gourley, Simon P. Langdon
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
Abstract Background Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment. This study sought to investigate the variation of expression of molecular components (GLUT1, HKI
Externí odkaz:
https://doaj.org/article/1b6941182481481888f6c50266b13ad2