Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Charli Dominguez"'
Autor:
Justin M. David, Charli Dominguez, Kristen K. McCampbell, James L. Gulley, Jeffrey Schlom, Claudia Palena
Publikováno v:
OncoImmunology, Vol 6, Iss 10 (2017)
Mesenchymalization is a cellular and molecular program in which epithelial cells progressively lose their well-differentiated phenotype and adopt mesenchymal characteristics. Tumor mesenchymalization occurs during the progression of cancer to metasta
Externí odkaz:
https://doaj.org/article/b287c2419c3c4e3faffb2aa16be96e38
Publikováno v:
Cells Tissues Organs. 203:128-138
Epithelial-mesenchymal transition (EMT) is recognized as a relevant process during the progression of carcinomas towards metastatic disease. Epithelial cancer cells undergoing an EMT program may acquire mesenchymal features, motility, invasiveness, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02103baeabb30c47d5ec812da59fa7f5
https://doi.org/10.1159/000446495
https://doi.org/10.1159/000446495
Publikováno v:
JCI Insight. 2
The complex signaling networks of the tumor microenvironment that facilitate tumor growth and progression toward metastatic disease are becoming a focus of potential therapeutic options. The chemokine IL-8 is overexpressed in multiple cancer types, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca022a6722d475b505f7fe21b45e09f2
https://doi.org/10.1172/jci.insight.94296
https://doi.org/10.1172/jci.insight.94296
Autor:
Claudia Palena, James L. Gulley, Jeffrey Schlom, Kristen K. McCampbell, Justin M. David, Charli Dominguez
Publikováno v:
OncoImmunology, Vol 6, Iss 10 (2017)
Oncoimmunology
Oncoimmunology
Mesenchymalization is a cellular and molecular program in which epithelial cells progressively lose their well-differentiated phenotype and adopt mesenchymal characteristics. Tumor mesenchymalization occurs during the progression of cancer to metasta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d185201ce5d82e0011c0e06b0cc434
https://doaj.org/article/b287c2419c3c4e3faffb2aa16be96e38
https://doaj.org/article/b287c2419c3c4e3faffb2aa16be96e38
Tumor growth and progression are the products of complex signaling networks between different cell types within the tumor and its surrounding stroma. In particular, established tumors are known to stimulate an inflammatory reaction via the secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7f98a23c4da430ca64320db78d54bd
https://europepmc.org/articles/PMC5698091/
https://europepmc.org/articles/PMC5698091/
Autor:
Jae K. Lee, Gabriela Mustata Wilson, Charli Dominguez, Benjamin Purow, Roger Abounader, Garrett R. Mullins, Desiree Floyd, Wenjun Xin, Aizhen Xiao, Thurl E. Harris, Melissa N. Yacur, Benjamin Kefas
Publikováno v:
Cancer Discovery. 3:782-797
Although diacylglycerol kinase α (DGKα) has been linked to several signaling pathways related to cancer cell biology, it has been neglected as a target for cancer therapy. The attenuation of DGKα activity via DGKα-targeting siRNA and small-molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f18d7ac7546f3898efcb424636fdea
https://doi.org/10.1158/2159-8290.cd-12-0215
https://doi.org/10.1158/2159-8290.cd-12-0215
Controlling the spread of carcinoma cells to distant organs is the foremost challenge in cancer treatment, as metastatic disease is generally resistant to therapy and is ultimately incurable for the majority of patients. The plasticity of tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda1db0be5844d71ef2cc58cfe75d014
https://europepmc.org/articles/PMC5274580/
https://europepmc.org/articles/PMC5274580/
Autor:
Laurey Comeau, Olga Mykhaylyk, Christian Plank, Oleksandr Seleverstov, Desiree Floyd, Charli Dominguez, Benjamin Kefas, Benjamin Purow
Publikováno v:
Neuro-Oncology. 14:1215-1226
The Notch pathway is dysregulated and a potential target in glioblastoma multiforme (GBM). Currently available Notch inhibitors block γ-secretase, which is necessary for Notch processing. However, Notch is first cleaved by α-secretase outside the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ad7900229cd6dbb5d8dff14031998e
https://doi.org/10.1093/neuonc/nos157
https://doi.org/10.1093/neuonc/nos157
Autor:
Romaine I. Fernando, Claudia Palena, Duane H. Hamilton, Charli Dominguez, Justin M. David, Kristen K. McCampbell
Publikováno v:
Oncotarget
// Romaine I. Fernando 1 , Duane H. Hamilton 1 , Charli Dominguez 1 , Justin M. David 1 , Kristen K. McCampbell 1 , Claudia Palena 1 1 Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af899d8538fb0ec38bf6e8fff08e852
https://pubmed.ncbi.nlm.nih.gov/27248176
https://pubmed.ncbi.nlm.nih.gov/27248176
Autor:
Laurey Comeau, Charli Dominguez, Alyse Frisbee, Fadila Guessous, Benjamin Purow, Roger Abounader, Desiree Floyd, Charles G. diPierro, Benjamin Kefas
Despite advances in the treatment of the most aggressive form of brain tumor, glioblastoma, patient prognosis remains disappointing. This failure in treatment has been attributed to dysregulated oncogenic pathways, as observed in other tumors. We and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0478ac7e5b3e4610b8498b9ac70afb47
https://europepmc.org/articles/PMC3829588/
https://europepmc.org/articles/PMC3829588/