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pro vyhledávání: '"Charli D. Baker"'
Publikováno v:
Molecular Biology of the Cell
Phosphatidylethanolamine (PE) and cardiolipin have specific roles in the activity and assembly of the mitochondrial respiratory chain supercomplexes, respectively, whereas phosphatidylcholine is redundant. Nonmitochondrial PE can be transported into
Autor:
Uroš Petrovič, Mohit Jain, Writoban Basu Ball, Kim A. Lagerborg, Charli D. Baker, Gašper Žun, Gabriel L. Apfel, Vishal M. Gohil, John K. Neff
Cardiolipin (CL) is a signature phospholipid of the mitochondria required for the formation of mitochondrial respiratory chain (MRC) supercomplexes. The destabilization of MRC supercomplexes is the proximal cause of the pathology associated with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc274ad9500836d6673434fd7a80d21
https://europepmc.org/articles/PMC6052229/
https://europepmc.org/articles/PMC6052229/
Autor:
Vishal M. Gohil, Valentin Cracan, Clary B. Clish, Vamsi K. Mootha, Marica Bakovic, Lin Zhu, Abbas Yaseen, Mohit Jain, Paul S. Brookes, Charli D. Baker
Publikováno v:
The Journal of Biological Chemistry
Background: Previous studies have shown that meclizine inhibits respiration in intact cells, but not in isolated mitochondria, via an unknown mechanism. Results: Meclizine directly inhibits PCYT2 (CTP:phosphoethanolamine cytidylyltransferase). Conclu