Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Charles-André Lemelin"'
Autor:
Charles-André Lemelin, Boris M. Seletsky, Kimberley K. Aalfs, Paul J. Lydon, Davis Heather, Yoshito Kishi, Kathleen A. Salvato, Bruce A. Littlefield, Lynda Tremblay, Murray J. Towle, Charles E. Chase, Yongchun Shen, Lori A. Singer, Melvin J. Yu, Wanjun Zheng, Bruce F. Wels, Monica Palme
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5551-5554
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.
Autor:
Roch Boivin, Yongchun Shen, Yuan Wang, Yoshiyuki Kawakami, Yimin Jiang, Hong Du, Hiroshi Shirota, Fabian Gusovsky, Atsushi Inoue, Robert D. Pelletier, Shawn Schiller, Megumi Ikemori-Kawada, Tomohiro Matsushima, Masaki Goto, Naoki Yoneda, Zhiyi Zhang, Charles-André Lemelin, Matthew J. Schnaderbeck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3155-3157
Inspired by natural product, LL-Z1640-2, clinical candidate, E6201 (22) was discovered in a medicinal chemistry effort through total synthesis. The modification on C14-position to N-alkyl substitution showed to be potent in vitro and orally active in
Autor:
Charles-André Lemelin, Patrice Préville, András Toró, Pierre Deslongchamps, Guillaume Bélanger
Publikováno v:
Tetrahedron. 55:4655-4684
Assembly of 13-membered TCC macrocyclic trienes are described and their transannular Diels-Alder reaction are investigated as a model study for the asymmetric synthesis of the ABC-ring system of (+)-maritimol. Albeit the original expectations that th
Publikováno v:
ChemInform. 30
A procedure is described for the stereospecific synthesis of 13-membered trienic macrocycles from suitable acyclic bis-allylic chlorides via an intramolecular gem-dialkylation of malononitrile or methyl cyanoacetate.
Autor:
Patrice Préville, Charles-André Lemelin, András Toró, Guillaume Bélanger, Pierre Deslongchamps
Publikováno v:
ChemInform. 30
Assembly of 13-membered TCC macrocyclic trienes are described and their transannular Diels-Alder reaction are investigated as a model study for the asymmetric synthesis of the ABC-ring system of (+)-maritimol. Albeit the original expectations that th
Publikováno v:
Tetrahedron Letters. 39:7839-7840
A procedure is described for the stereospecific synthesis of 13-membered trienic macrocycles from suitable acyclic bis-allylic chlorides via an intramolecular gem-dialkylation of malononitrile or methyl cyanoacetate.